This paper presents the effect of ventilation parameters on the 222Rn inhalation dose in an underground uranium mine located in east Singhbhum of Jharkhand, India. This study reveals that the airflow rate variable statistically significantly predicts the 222Rn dose variable in the mine. On the other hand, no significant effect of other ventilation parameters such as barometric pressure, dry-bulb, and wet-bulb temperatures on 222Rn inhalation dose in the stopes was observed due to negligible variations in their values. Therefore, the airflow rate plays a significant role in reducing the effective radiation dose level in mines. In this study, the Equivalent Equilibrium Radon concentration (EER) and total effective radiation dose received by the miners involved in different mining activities in the various locations of the mine were found to be in ranges of 130–420 Bq m−3 and 0–3.17 mSv y−1, respectively. It also reveals that the miners involved in the stope preparation and timbering were exposed to more radiation than other mining activities. Under the existing ventilation conditions, the total effective radiation dose was far below the safe limit of 20 mSv y−1 recommended by the International Commission of Radiological Protection.