The article considers the experience gained in underground mining in Yakutia in terms of geological conditions of local ore bodies, as well as the mining methods used and equipment employed. The main factors of permafrost, having positive and negative effects on the safety and efficiency of mining are identified. The research data on deterioration of underground mining conditions during transition to the subpermafrost levels are given. The solutions proposed make it possible to improve the efficiency of underground mining of ore bodies with lower content of commercial minerals, without infrastructure available and in complex geological conditions, including subpermafrost reserves.