The management of reverse osmosis (RO) concentrate remains a challenging task for operators of Landfill Leachates Treatment Plants. In this article we suggest an integrated treatment scheme for RO concentrate that combines solar distillation, struvite precipitation to reduce ammonia content of the distillate and biological treatment of the supernatant either with mixed cultures of bacteria or with microalgae. Experiments in a pilot-scale solar still, equipped with underfloor heating system, showed that the production rate of the distillate ranged up to 3.17 L/d m2. The distillate was characterized by elevated average concentrations of ammonium nitrogen; 2028 mg/L and 1358 mg/L in the two experiments conducted, respectively. A decreasing trend on concentrations of NH4+-N was noticed during these experiments, while the opposite was observed for COD. Struvite recovery experiments showed that the optimum Mg:NH4:PO3 ratio was that of 2:1:5.8. Under these conditions, the NH4+-N removal reached 88%. Further treatment of the process supernatant into a 4-L hybrid sequencing batch reactor with biocarriers and activated sludge achieved NH4+-N removal higher than 98% in Phases C and D, where 450 and 600 mL of supernatant were added, respectively. Similar removal was also observed in a 2-L bioreactor with microalgae Chlorella sorokiniana when 150 mL of struvite supernatant were added (Phase B) while further increase of the amount of added supernatant to 200 mL resulted to a sharp stop of NH4+-N consumption (Phase C). Calculations for a landfill serving 20,000 inhabitants and a daily RO concentrate production of 6 m3/d showed that the required area for the construction of the solar still was 1893 m2 and the volumes of the hybrid and the microalgae reactor were 54 m3 and 60 m3, respectively. The recovered solid material of struvite process, after characterization for heavy metals and organic micropollutants, could be reused to the fertilizers industry.