Unconventional Response Research Articles

Artemisinin pressure in field isolates can select highly resistant Plasmodium falciparum parasites with unconventional phenotype and no K13 mutation.

Artemisinin resistance, which poses a serious threat to malaria control efforts, is monitored in the field by delayed parasite clearance in patients, elevated parasite survival rate in the ring-stage survival assay, and mutations in the Plasmodium falciparum kelch13 gene. However, sporadic cases of artemisinin-resistant malaria do not meet all of these criteria, highlighting that our understanding of artemisinin resistance is still incomplete. Here, we selected for artemisinin resistance in vitro in nine P. falciparum field isolates from Africa, Asia, and South America. Artemisinin pressure selected highly resistant parasites in all lineages, but only one acquired a validated pfkelch13 mutation. Phenotypic tests evidenced an unconventional response of selected parasites that can be artemisinin-resistant only at an advanced ring age, making them undetectable by the standard "0-3 h" test used to monitor resistance. These results highlight the need for broader approaches to artemisinin resistance monitoring.

Prognosis of patients with Hodgkin lymphoma and indeterminate response to PD-1 inhibitor therapy: considerations for application of LYRIC criteria in real clinical practice.

PD-1 inhibitors have shown unconventional response patterns in classic Hodgkin lymphoma (cHL). These include the phenomenon of pseudoprogression, highlighting the need for specialized response criteria such as the LyRIC, which stringened definitions for disease progression with introduction of indeterminate response category. Despite their potential utility, these provisional criteria are currently underutilized and require further refinement through clinical practice data collection. In this retrospective study LyRIC criteria were systematically used for response assessments in 180 patients with refractory cHL treated with nivolumab. Median follow-up was 60months. Indeterminate response (IR) was a frequent phenomenon in study population: at 3months of therapy 63 (35%) patients had an indeterminate response (IR1 7%, IR2 23%, IR3 6%). Among them 18 (29%) achieved an objective response with continued monotherapy. There were no differences in OS or TTNT depending on the type of IR. IR was the best achieved response in 45 (25%) patients. Patients with IR had favorable prognosis with no difference in OS, PFS and TTNT comparing to patients with PR when subsequent therapy was initiated due to disease progression. Patients with IR may achieve prolonged disease control or a deeper response upon continuing treatment. These findings support the broader implementation and adjustment of LyRIC criteria in clinical practice to enhance decision-making in cHL patients treated with immunotherapy.

Enhancing SrBi₂Nb₂O₉ ceramics: The role of neodymium substitution in structural, dielectric, and ferroelectric properties

Enhancing SrBi₂Nb₂O₉ ceramics: The role of neodymium substitution in structural, dielectric, and ferroelectric properties

18F]FDG PET/CT Integration in Evaluating Immunotherapy for Lung Cancer: A Clinician's Practical Approach.

The advent of immune checkpoint inhibitors (ICIs) has revolutionized the treatment paradigm of lung cancer, resulting in notable enhancements in patient survival. Nevertheless, evaluating treatment response in patients undergoing immunotherapy poses distinct challenges due to unconventional response patterns like pseudoprogressive disease (PPD), dissociated response (DR), and hyperprogressive disease (HPD). Conventional response criteria such as the RECIST 1.1 may not adequately address these complexities. To tackle this issue, novel response criteria such as the iRECIST and imRECIST have been proposed, enabling a more comprehensive assessment of treatment response by incorporating additional scans and considering the best overall response even after radiologic progressive disease evaluation. Additionally, [18F]FDG PET/CT imaging has emerged as a valuable modality for evaluating treatment response, with various metabolic response criteria such as the PERCIMT, imPERCIST, and iPERCIST developed to overcome the limitations of traditional criteria, particularly in detecting pseudoprogression. A multidisciplinary approach involving oncologists, radiologists, and nuclear medicine specialists is crucial for effectively navigating these complexities and enhancing patient outcomes in the era of immunotherapy for lung cancer. In this review, we delineate the key components of these guidelines, summarizing essential aspects for radiologists and nuclear medicine physicians. Furthermore, we provide insights into how imaging can guide the management of individual lung cancer patients in real-world multidisciplinary settings.

Keeping up with the decarbonization: Conceptualizing and investigating incumbents’ responses to transition pressures in the post-Paris world

Keeping up with the decarbonization: Conceptualizing and investigating incumbents’ responses to transition pressures in the post-Paris world

Spin-polarized second-order nonlinear Hall effect in 8-Pmmn monolayer borophene

The second-order nonlinear Hall effect in 8-Pmmn monolayer borophene under the influence of an out-of-plane electric field and intrinsic spin–orbit interaction is reported. This unconventional response sensitive to the breaking of discrete and crystal symmetries can be tuned by the applied electric field, which can vary the bandgap induced by spin–orbit coupling. It is described by a Hall conductivity tensor that depends quadratically on the applied electric field. We find that the nonlinear Hall effect strongly depends on the spin polarization. In particular, it exhibits out of the phase character for spin-up and spin-down states. Remarkably, it undergoes a phase flip in the spin-up state at a large out-of-plane electric field that generates a staggered sublattice potential greater than the spin–orbit interaction strength. It is shown that the nonlinear Hall effect in the system originates from the broken inversion symmetry that plays an indispensable role in developing finite Berry curvature and its relevant dipole moment. It is found that at zero temperature, the nonlinear Hall response is maximal when the Fermi energy is twice the bandgap parameter and vanishes at large Fermi energies. Notably, the peak of nonlinear Hall response shifts to lower Fermi energies at finite temperature.

Unconventional Polarization Response in Titanite-Type Oxides due to Hashed Antiferroelectric Domains.

Domains in a crystal, which have crystallographic uniformity and are geometrically segmented, typically arise from various phase transitions. The physical properties within individual domains are inherently the same as those in the homogeneous bulk. As a result, sufficiently large domains have little influence on the bulk properties. However, as the domains decrease in size to the nanoscale, for instance, due to multiple phase instabilities or spatial inhomogeneities, then the materials often acquire exceptional functionalities that are unattainable without these domains. This effect is exemplified by the ultrahigh dielectric and piezoelectric responses observed in ferroelectric oxides with nanoscale polar domains as well as in ferroelectric relaxors with polar nanoclusters. Here, we demonstrate that hashed nanoscale domains in an antiferroelectric material are also capable of boosting dielectric permittivity in an unconventional way. This discovery has been made in an antiferroelectric titanite-type oxide, CaTi(Si1-xGex)O5, in which the permittivity significantly increases when the antiferroelectric order becomes short-range. Our transmission electron microscopy observations have clarified that polar regions simultaneously appear around antiphase boundaries in the antiferroelectric phase of CaTi(Si1-xGex)O5. As the concentration of the antiphase boundary increases, the polar regions become denser and play a crucial role in boosting the permittivity. At the composition of x = 0.5, the value of the permittivity finally reaches double that in the bulk and shows excellent linearity, at least until an electric field of 500 kV/cm is applied. The present findings highlight the promise of domain engineering for boosting the permittivity in antiferroelectrics as a way to develop materials with excellent dielectric properties.

Unconventional optical response in monolayer graphene due to dominant intraband scattering

Unconventional optical response in monolayer graphene due to dominant intraband scattering

Fed and ECB reaction functions during quantitative easing: Three phases of monetary policy, both conventional and unconventional

Fed and ECB reaction functions during quantitative easing: Three phases of monetary policy, both conventional and unconventional

Balto and Togo during the cold winter of Alaska (1925): the two canine heroes in the fight against diphtheria.

In recent years, diphtheria has re-emerged in areas with inadequate vaccination coverage, and Europe has not been spared with several cases among migrants. Diphtheria is a potentially fatal infection caused mainly by toxigenic strains of Corynebacterium diphtheriae. Due to the high mortality rate, especially among young children, the fight against diphtheria is considered one of the first conquests of immunization. In the history of medicine, there is a unique case of an unconventional response to a diphtheria outbreak in which sled dogs were used to overcome the supply difficulties of diphtheria antitoxin. The mass media followed the medical response to the outbreak and raised audience awareness of public health issues. The facts of Nome, Alaska, in 1925 can serve as a catalyst to rethink conventional responses to diphtheria outbreaks in low-income countries today and promote mass media awareness of public health importance.

Unconventional frequency response analysis of PEM fuel cell based on high-order frequency response function and total harmonic distortion

Unconventional frequency response analysis of PEM fuel cell based on high-order frequency response function and total harmonic distortion

Symmetry-based requirement for the measurement of electrical and thermal Hall conductivity under an in-plane magnetic field

The in-plane (thermal) Hall effect is an unconventional transverse response when the applied magnetic field is in the (heat) current plane. In contrast to the normal Hall effect, the in-plane Hall effect requires the absence of certain crystal symmetries, and possibly manifests a non-trivial topology of quantum materials. An accurate estimation of the intrinsic in-plane (thermal) Hall conductivity is crucial to identify the underlying mechanisms as in the case of the Kitaev spin-liquid candidate alpha-RuCl3. Here, we give the symmetry conditions for the in-plane Hall effect and discuss the implications that may impede the experimental evaluation of the in-plane (thermal) Hall conductivity within the single-device measurement. First, the lack of symmetry in crystals can create merohedral twin domains that cancel the total Hall signal. Second, even in a twin-free crystal, the intrinsic response is potentially contaminated by the out-of-plane conduction in three-dimensional systems, which is systematically unavoidable in the in-plane Hall systems. Third, even in a quasi-two-dimensional system, the conversion of (thermal) resistivity, rho (lambda), to (thermal) conductivity, sigma (kappa) requires protocols beyond the widely-used simplified formula due to the lack of in-plane-rotational symmetry. In principle, two independent sample devices are necessary to accurately estimate the s_xy (k_xy). As a case study, we discuss the half-integer quantization of the in-plane thermal Hall effect in the spin-disordered state of alpha-RuCl3. For an accurate measurement of the thermal Hall effect, it is necessary to avoid crystals with the merohedral twins contributing oppositely to k_xy, while the out-of-plane transport may have a negligible effect. To deal with the field-induced rotational-symmetry breaking, we propose two symmetry-based protocols, improved single-device and two-device methods.

Two-dimensional Mg2Si-111: A direct bandgap semiconductor with excellent optical response properties predicted by first-principles calculations

Two-dimensional Mg2Si-111: A direct bandgap semiconductor with excellent optical response properties predicted by first-principles calculations

Chiral Mechanical Metamaterials for Tunable Optical Transmittance

AbstractFlexible metamaterials have been increasingly harnessed to create functionality through their tunable and unconventional response. Herein, chiral unit cells based on Archimedean spirals are employed to transform a linear displacement into twisting. First, the effect of geometry on such extension‐twisting coupling is investigated. This unravels a wide range of highly nonlinear behaviors that can be programmed. Additionally, it is demonstrated that by combining the spirals with polarizing films one can create mechanical pixels capable of modulating the transmission of light through deformation. Guided by experiments and numerical analyses, pixels are arranged in 2D arrays to realize black and white and color displays, which reveal distinct images at different states of deformation. As such, the study puts forward a methodology for the design of an emerging class of flexible devices that can convert nonlinear elastic deformation to tunable optical transmittance.

An Urban Tree (Tabebuia argentea) Exhibits Higher Sensitivity to Environmental Conditions than an Urban Palm (Ptychosperma macarthurii) Growing in the Same Roof Garden: An Implication for Sustainable Urban Water Use

Roof gardening is popular for increasing green space in cities due to the restricted urban areas. However, when watering plants on a roof garden, one should consider loading capacity of the roof, which may limit water supply to the plants therein. To improve the efficiency in irrigating trees in a roof garden, we evaluated plant water status, represented by midday leaf water potential (ΨL), and leaf gas exchange parameters including stomatal conductance (gs) and net photosynthesis (An) of a tree (Tabebuia argentea, Ta) and a palm (Ptychosperma macarthurii, Pm) species, which dominate the garden. The ΨL mediated responses of gs and An, regulating plant water use and growth, to soil moisture. Results showed that ΨL of Ta significantly varied with changes in soil moisture, being low at low and high soil moisture. Nevertheless, gs of Ta linearly decreased when ΨL increased, suggesting a stronger response of gs to atmospheric demand. In contrast, no significant responses among the study variables were observed in Pm. For both species, An initially increased with gs and saturated after gs reached 200 mmol m-2 s-1, indicating similar stomatal regulation on atmospheric carbon dioxide absorption. The limited space for root growth and the location with surrounded building walls contributed to unconventional response patterns observed in Ta. Nonetheless, our results suggested that Ta was more sensitive to changing environments, especially the atmospheric demand, than Pm. Additionally, Ta should be irrigated during daytime and when atmospheric vapor pressure deficit is less than 2.6 kPa to allow high photosynthesis and evaporative cooling while Pm may be watered less frequently to reduce the roof’s loading and save water. This initial investigation implied that maintaining urban trees using appropriate irrigation that is specific to tree species is the key to maximize benefits from urban trees and optimize urban water use.

Random networks of disconnected nanoparticles in dielectric layers as a source of electric responsivity

Random networks of disconnected nanoparticles in dielectric layers as a source of electric responsivity

Thickness-Dependent Topological Hall Effect in 2D Cr5 Si3 Nanosheets with Noncollinear Magnetic Phase.

Antiferromagnets with noncollinear spin order are expected to exhibit unconventional electromagnetic response, such as spin Hall effects, chiral abnormal, quantum Hall effect, and topological Hall effect. Here, 2D thickness-controlled and high-quality Cr5 Si3 nanosheets that are compatible with the complementary metal-oxide-semiconductor technology are synthesized by chemical vapor deposition method. The angular dependence of electromagnetic transport properties of Cr5 Si3 nanosheets is investigated using a physical property measurement system, and an obvious topological Hall effect (THE) appears at a large tilted magnetic field, which results from the noncollinear magnetic structure of the Cr5 Si3 nanosheet. The Cr5 Si3 nanosheets exhibit distinct thickness-dependent perpendicular magnetic anisotropy (PMA), and the THE only emerges in the specific thickness range with moderate PMA. This work provides opportunities for exploring fundamental spin-related physical mechanisms of noncollinear antiferromagnet in ultrathin limit.

Unconventional OFF-ON Response of a Mono(calix[4]arene)-Substituted BODIPY Sensor for Hg2+ through Dimerization Reversion.

A new selective fluorogenic chemosensor for Hg2+, which combines a calixarene derivative with a BODIPY core as a fluorescent reporter, is described. The remarkable change in its fluorogenic properties in DMSO and CHCl3 has been analyzed. A study of its spectral properties on dilution, along with molecular modeling studies, allowed us to explain that this behavior involves the formation of a J-dimer, as well as how the sensing mechanism of Hg2+ proceeds.

Effective quasiclassical models for odd-frequency superconductivity: Energy-inversion symmetry, preserved spectral weight, and Meissner response

The odd-frequency superconducting state appears generally in hybrid structures consisting of conventional superconductors and other materials, and features electrons that form temporally nonlocal Cooper pairs. The quasiclassical theory of superconductivity has been extensively used to model such systems, finding in many cases excellent agreement with experimental measurements. Therefore, it is of interest to study effective models of odd-frequency superconductivity to predict new phenomena associated with this form of unconventional pairing. We establish necessary criteria that the quasiclassical Green's functions in odd-frequency superconducting systems in the dirty limit must satisfy in order to be physically reasonable, including conservation of spectral weight. We show that it is possible to write down effective models, which satisfy all the above-mentioned criteria, but which still predict different behavior when it comes to the density of states and the magnetic response of the superconductor. For instance, an effective model for the odd-frequency anomalous Green's function that gives a conserved spectral weight can yield either a peaked or gapped density of states at the Fermi energy, and exhibit conventional, zero, or unconventional Meissner response. This finding demonstrates the importance of carefully considering the properties of effective models describing odd-frequency superconductivity in order to obtain physically reasonable results.

Visual Securitization: Commemorating the Partisan War in Lithuanian Foreign and Security Policy

In 2008 and 2014 the Russian-Georgian war, the military conflict in Ukraine, and the annexation of Crimea have had an impact on Lithuanian foreign and security policy. In the context of these events, Lithuania was concerned about the mobilization of conventional security measures, i.e., strengthening its national defense sector. However, the role as well as the impact of “soft” (unconventional) response devices and strategies in the Lithuanian case has still received little academic interest. This paper, using the analysis of visual collective memory practices (monuments), aims to show the links between collective memory as well as its visually tangible forms and the formation of foreign and security policy in Lithuania. By examining the visual practices reminiscent of guerrilla warfare built in Lithuanian public spaces after 2014, it is revealed how the use of collective memory contributed to the perceived threat from Russia, which had a significant impact on the formation and implementation of foreign and security policy.