Uncontrolled Blood Sugar Research Articles

Major Lower Extremity Amputations due to Diabetes Mellitus Complications

Background: Lower limbs ulcers and wounds, Charcot foot with the presence of peripheral neuropathy or peripheral vascular disease are common complications of the diabetes mellitus (DM). Major extremity amputations (below and above knee) are one of the common surgical procedures performed due to DM complications. Objective: To review the amputations performed due to diabetes mellitus (DM) complications with other associated illness, commonly isolated bacteria, and the demography of the patients in a public general hospital. Materials and Methods: We retrospectively reviewed the cases of above and below the knee amputations due to DM complications from January 2012 to December 2016. The age, gender, duration of DM anyone having, bacteria isolated, vascular condition of the lower limbs, other diseases anyone having, post-surgery wound conditions and status of the ambulation after surgery were analyzed. Results: A total of 53 amputations of the limbs of 51 patients were performed. Below knee amputations were performed on 43 (81.83%) limbs and male gender were 35(68.62%). The mean age of the patient was 57.6±12.01 years (range 31-91 years). The three most common bacteria isolated were Klebsiella pneumoniae, Staphylococcus aureus, Enterobacter cloacae. About 85% of these bacteria were sensitive to commonly used first line of antibiotics like co-amoxiclav and ciprofloxacin. Fifty cases (98.03%) had diabetes for more than five years. End stage renal disease (ESRD) and ischaemic heart disease (IHD) were the other common co-morbidities observed. Conclusion: Major lower limb amputations (below and above the knee) due to uncontrolled blood sugar are common surgical procedures performed on DM. Majority of the bacteria were sensitive to commonly used first line of antibiotics but still 15% were not sensitive and bacteria isolation, sensitivity with the drugs were also important for the treatment of the infection.

Pengaruh Program Penanggulangan Penyakit Kronis (PROLANIS) terhadap Kadar Gula Darah Pasien Diabetes Melitus Tipe 2

Introduction: According to the International Diabetes Federation (IDF) in 2019, it is predicted that the number of people with diabetes mellitus (DM) will increase by 51% in 2045 globally. DM leads to complications in all parts of the body and affects the quality of life. Prevention of complications has been carried out by Indonesian Health Insurance (BPJS) through the Chronic Disease Management Program (PROLANIS), with the aim that chronic disease participants can achieve optimal quality of life, one of which is marked by controlled blood sugar levels. Objective: The purpose of this study was to analyze the effect of PROLANIS on patient compliance in taking the medication and controlling the patient's blood sugar. Method: The research method used an observation design for two groups of type 2 DM patients, (1) patients who participated in the Chronic Disease Management Program and (2) patients who did not follow the Chronic Disease Management Program, to then analyze the level of adherence and blood sugar levels on day 0. and the 30th. Data analysis using Chi-square test. Results and discussion: The results of this study showed that on the 30th day, the blood sugar levels of the two groups of patients with type 2 diabetes were different (p=0.019), the risk of uncontrolled blood sugar levels in the group taking the Chronic Disease Management Program was 0.53 times lower than the group. who did not follow the program (risk ratio=0.53). Conclusion: It can be concluded that there is a relationship between patient participation in the Chronic Disease Management Program and medication adherence so that it has an impact on controlling the patient's blood sugar levels.

Can Uncontrolled Blood Sugar Trigger Early Presentation of a Long Term Diabetic Complication? A Case Report of Lymphocytic Mastitis in a Recently Diagnosed Diabetic Patient

Can Uncontrolled Blood Sugar Trigger Early Presentation of a Long Term Diabetic Complication? A Case Report of Lymphocytic Mastitis in a Recently Diagnosed Diabetic Patient

Mucormycosis in RT-PCR negative Covid 19 patient with newly diagnosed Diabetes Mellitus: A Case Report

Corona Virus Disease 2019 (COVID 19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in Wuhan city of China in December 2019. Since then, the disease has spread very rapidly which has led to the current pandemic. Secondary infections are reported now a days during the illness in Covid-19 patients of any age and patients recovered from COVID 19. The high-risk conditions prone for opportunistic infections are uncontrolled blood sugar levels, prolonged steroid usage and oxygen therapy. Mucormycosis is highly invasive secondary infection. Early diagnosis along with surgical and medical intervention and control of all risk factors plays a crucial role. Delay in presentation of patient to medical care is really challenging to the physicians and ENT surgeons.

PDB1 Evaluation of Health-Related Quality of Life of Patients with Type 2 Diabetes Mellitus at a Tertiary Care Hospital in Ethiopia

Type 2 diabetes mellitus (T2DM) and its treatment adversely affect patients’ health-related quality of life (HRQoL). This study aimed to assess HRQoL and its predictors among T2DM patients at a tertiary care hospital in Ethiopia. A paper-based, face-to-face cross-sectional study was conducted among patients with T2DM at Tikur Anbessa Specialized Hospital in Ethiopia. We collected data using a validated Amharic version of 5-level EuroQol-5 dimensions (EQ-5D-5L) instrument. Descriptive statistics were used to present patient demographic and clinical characteristics. Kruskal-Wallis and Mann-Whitney U tests were performed to identify factors associated with patients’ HRQoL. Utility scores were calculated using disutility coefficients of the Ethiopian general population. Statistical significance was determined at p < 0.05. A total of 352 patients responded (response rate of 97.8%) with a mean (SD) age of 64.43 (10.61) years. Reported health problems were mostly in the pain/discomfort (67.3%) domain followed by mobility (60.5%), whereas the usual activities domain (34.1%) was the least health problem being reported. The mean (SD) utility and EQ-VAS scores were 0.87 (0.17) and 76.38 (13.85), respectively. Older age, higher educational level, longer duration since diagnosis of diabetes, uncontrolled blood sugar level, use of insulin injection, and diabetes-related complications were significantly associated with lower utility scores, while higher monthly household income was related to better health utility and EQ-VAS scores (p < 0.05). Overall, patients with T2DM had lower HRQoL than the general population. The health utility values generated in this study can be useful to assess clinical outcomes and perform economic evaluations to inform decisions about alternative interventions for T2DM patients.

Prevalence of First Diagnosed Atrial Fibrillation in Patients Admitted with Acute Coronary Syndrome and with Impaired Renal Function with and without Diabetes Mellitus

Objective: To determine the prevalence of first diagnosed atrial fibrillation in patients admitted with acute coronary syndrome and with impaired renal function with and without diabetes mellitus.&#x0D; Methodology: A total of 434 patients were selected from two different hospitals, 361 from NICVD, Tando Muhammad Khan and 73 from Isra University Hospital, Hyderabad. Both males and females, aged between 18 years to 70 years, first ever presented &amp; admitted with acute coronary syndrome (ACS) and renal impairment were included and whereas, patients with atrial fibrillation (AF) other than first diagnosed, previous history of myocardial infarction/coronary artery bypass grafting (CABG), known case of chronic kidney disease/on dialysis, history of cerebrovascular accident (CVA), patient with valvular heart disease, and pregnant women were excluded from this study. Baseline and clinical data was collected to determine the association with the prevalence of first diagnosed AF through chi-square test and a p value of &lt;0.05 was considered as statistically significant.&#x0D; Results: The mean age ± SD was 49.32±12.47 years. Among them majority were males 66.35% and rural residents 51.15% respectively. The most common risk factor observed in our study was presence of hypertension (N = 231, 53.22%) and among all ACS patients, most common type of ACS was unstable angina (N = 195, 44.93%). The overall prevalence of first diagnosed atrial fibrillation was 12.44% (N = 54) and the overall prevalence of diabetes mellitus was 39.63% (N = 172). Mean random blood sugar levels in diabetic patients was 203.32±105.60 mg/dL, hypertensive patients with DM (48.14%), and patients with STEMI with DM (12.96%) were significantly associated with increased prevalence of first diagnosed atrial fibrillation, p value &lt;0.05.&#x0D; Conclusion: Prevalence of first diagnosed AF is comparatively higher in our study because of the underlying renal impairment. Modifiable risk factor like uncontrolled blood sugar levels has significance association with first diagnosed AF.

Bone and mineral disorders among Saudi diabetics

Increasing bone and mineral changes which caused by both diabetes type 1 and type 2 can raise fracture risks for a period of time during illness and low blood sugar levels. The connection between diabetes and bone fragility is further complicated by the variable effects on the skeleton by various diabetic medications. Diabetic patients are at a higher risk of bone and mineral density alterations, osteoporosis and fragility fractures. Diabetic patients are often susceptible to develop various conditions due to malnutrition, uncontrolled blood sugar and lack of proper follow up regiment. Diabetics should be tested for osteoporosis risk and given effective prevention strategies. Preventing osteoporosis would require interventions such as sufficient vitamin D and calcium intake, physical exercise and exposure to sunlight.

Diabetes Mellitus: Insights from Epidemiology, Biochemistry, Risk Factors, Diagnosis, Complications and Comprehensive Management

Diabetes mellitus has become a serious and chronic metabolic disorder that results from a complex interaction of genetic and environmental factors, principally characterized by hyperglycemia, polyuria, and polyphagia. Uncontrolled high blood sugar can result in a host of diabetic complications. Prolonged diabetes leads to serious complications some of which are life-threatening. The prevalence of diabetes patients is rising at epidemic proportions throughout the world. Every year, a major portion of the annual health budget is spent on diabetes and related illnesses. Multiple risk factors are involved in the etiopathogenesis of the disease and turning the disease into an epidemic. Diabetes, for which there is no cure, apparently can be kept under control by maintaining self-care in daily living, effective diabetes education, with comprehensive improvements in knowledge, attitudes, skills, and management. In this review, we focused on the biochemical aspects of diabetes, risk factors including both environmental and genetic, disease complications, diagnosis, management, and currently available medications for the treatment of diabetes.

Factors related to the uncontrolled fasting blood sugar among type 2 diabetic patients attending primary health care center, Abha city, Saudi Arabia.

To identify risk factors related to uncontrolled fasting blood sugar among type 2 diabetic patients. A systematic random sampling technique was followed to include 450 diabetic patients attending Al-Qabil Primary Health Care Center in Abha City, Saudi Arabia. Collected data comprised sociodemographic characteristics (age, gender, height, weight, education, employment, body mass index, and smoking), while disease-related characteristics included duration of diabetes, fasting blood sugar control, hypertension, and regularity of follow up visits. Fasting blood sugar was uncontrolled among 76.9% of selected patients with type 2 diabetes mellitus. Overweight and obesity were present among 81.6%. Significant risk factors for uncontrolled blood sugar included older age, male gender (P=.037), illiteracy (P=.020), being employed (P=.003), longer duration of disease (P=.023), hypertension (P=.010), and smoking (P=.001). Prevalence of uncontrolled fasting blood sugar is high among patients with type 2 diabetes mellitus. Risk factors associated with uncontrolled fasting blood sugar include older age, male gender, illiteracy, being employed, longer duration of disease, hypertension, smoking, and obesity. Therefore, for better control of blood sugar among diabetics, it is recommended to control the blood pressure and body weight of diabetics and avoid smoking.

Clinical Study of Risk Factors for Diabetic Maculopathy

Aim: To determine the association between various systemic risk factors with diabetic maculopathy. Methodology: A prospective observational study was conducted on 50 patients having diabetic maculopathy. Patients with maculopathies secondary to Vitreous Haemorrhage, Ocular disorders like Glaucoma, Uveitis, Advanced Diabetic Eye Disease, Vitreo-macular traction, maculopathy along with proliferative diabetic retinopathy, ischemic maculopathy, and history of laser treatment in last six months were excluded from the study. Data was collected using a structured proforma that included name, age, sex, occupation, height, weight, history of other systemic diseases like hypertension, investigations and treatment taken in past, family history, duration of DM, smoking, hyperlipidemia, hyperglycemia and nephropathy. Results: Out of 50 patients, 38 (76%) were males and 12 (24%) were females suggestive of male predominance. Mean age of the patient was 57.36±11.65 years in males and 56.67±10.17 years in females. Among 50 patients, 19 patients had diabetes mellitus for 6-10 years duration, 14 patients had diabetes mellitus for 1-5 years, in 12 patients for 11-15 years, in 2 patients for 16-20 years, in 2 patients for 21-25 years and only 1 patient more than 25 years. Mean duration of DM was 12.2±6.1 years. Majority of patients having maculopathy had duration of DM up to 20 years. Among 50 patients, 27 patients (54%) had systemic hypertension, 37 patients (74%) had uncontrolled blood sugar level, 29 patients (58%) were found to have hyperlipidemia and 20 patients (40%) had nephropathy. Among 50 patients, pseudophakia was noted in 7 patients (14%), obesity was noted in 21patients (42%). Eleven patients (22%) were found to have anemia, 6 patients (12%) had family history of DM and 13 patients (26%) had history of smoking. Conclusion: Hyperglycemia, hypertension, duration of DM, hyperlipidemia are the major risk factors for the development and progression of diabetic maculopathy. While anemia, smoking, and obesity, family history of DM are the less significant risk factors.

Palliative Wound Care for PALTC

Palliative Wound Care for PALTC

Evaluating the quality of care for patients with type 2 diabetes mellitus based on the HbA1c: A national survey in Iran

ObjectiveThe present study was conducted to evaluate the quality of care for type2 diabetic patients based on the HbA1c in Iran. Materials and methodsThis cross-sectional study was conducted in 2019 among patients with type 2 diabetes in Iran. The data were collected through a three-part questionnaire including demographic information, disease-related records, and HbA1C status of patients. Multiple logistic regression was used to investigate the relationship between the outcome variable (HbA1c status) and the independent variables in Stata 12. ResultsThe mean HBA1c was 8.01 ± 1.76% among 1,198 diabetic patients, and more than 66% of them had HBA1c above 7%, i.e. they had uncontrolled blood sugar levels. HBA1c has the highest average among people with more than 10 years of diabetes (8.47 ± 1.77%), self-employed people (8.36 ± 1.94%), illiterate people or those with elementary education (8.13 ± 1.76%) and people with poor economic status (8.12 ± 1.79%). Also, in the final model, people with more than 10 years of disease history had the highest prevalence of HBA1C > 7 with a chance ratio of 3.28 (P < 0.001, 95%CI: 2.37–4.53) and followed by illiterate people or those with elementary education with a chance ratio of 1.6 (P = 0.020, 95%CI: 1.08–2.39) compared to those with high school diploma or academic education. ConclusionThe prevalence of adverse HBA1c in 66% of the studied subjects indicates an inappropriate status of diabetes control in Iran. This indicates the poor quality of services provided to the diabetics. This is a warning sign and requires appropriate interventions to improve the quality of services provided to diabetic patients.

Validation of Finnish Diabetes Risk Score Indonesia Version in Yogyakarta

Diabetes mellitus (DM) has developed as a major public health problem in the world. It is estimated that around 50% of diabetics have not been diagnosed in Indonesia, and only two-thirds of those diagnosed are undergoing treatment. This condition must be prevented. The purpose of this study is to determine the validity and reliability of the Indonesian version of FINDRISC as an instrument for predicting type 2 diabetes mellitus (T2DM). This study was an observational study with a cross-sectional design on 60 research subjects who are indigenous people of Yogyakarta who live in Yogyakarta, which can be proven by Identity Cards by the inclusion and exclusion criteria. Validity is tested by the validity of criteria by type while using the area under the receiver-operating curve (ROC-AUC), while reliability is tested by internal consistency using Cronbach's Alpha (α). The results showed that as many as 14 people, or 23.33% experienced uncontrolled fasting blood sugar and 15 people had a risk score of FINDRISC more than 10. Based on the ROC AUC analysis, the value of 0.935 (95% CI 0.865 1.00) with a cut-off point of 10 with the value of Sn = 85%, Sp = 95%, PPV = 85%, NPV = 95%, +LR = 5.66, and -LR = 0.15. Based on the reliability test, the Cronbach's value of 0.727 is obtained. The FINDRISC questionnaire is categorized as valid and reliable so that it can be a screening tool for understanding.

The treatments of COVID-19 patient with diabetes mellitus: a case report

Diabetes mellitus or uncontrolled blood sugar is one of the factors causing the severity risk of COVID-19 infection. The researchers from China and Italy also find a profound connection of the old age patients who have chronic illness comorbid are tend to have a higher risk of enduring serve COVID-19, and have a higher number of deaths. Until this report is written, there are no medicines nor vaccines to treat COVID-19 completely. This article reports KTK, a 57 years old woman, Balinese, was diagnosed with COVID-19 and was treated because of the loss of consciousness. Patient had already done the op debridement amputation for left foot digit II-V and the wound of the patient got worsen. Patient also had blood sugar variability which complicated the insulin therapy and inhibits the patient’s recovery. On her way, the patient’s respiratory system got worsen. Diabetes is strongly connected with a higher risk of severe COVID-19 and has a higher death rate compared to controlled blood sugar. The purpose of the guidance for COVID-19 patients with Diabetes is to prove that comprehensive glycemic control and blood glucose monitoring have a good result of the treatments for COVID-19 patients with Diabetes, also reduce the complication from the comorbid of chronic illness (diabetes), and avoiding the undesirable possibilities about the treatments.

An Evaluation of Medication Adherence to Antidiabetic Drugs: A Prospective Study

Adherence to prescribed medication is an imperative issue which can be directly linked with the management of diabetes mellitus. WHO identifies poor adherence is the most significant cause of uncontrolled blood sugar level. A prospective observational study was conducted in in-patients admitted to general medicine department diagnosed with diabetes mellitus from September 2019 to February 2020. Data was collected from case sheets of patients for age, gender, and socio- economic data. Informed consent was obtained from patients or bystanders before study. Direct interview was conducted with patients using standardized questionnaire known as MMAS-8. Patient’s adherence to medications was assessed using scores obtained from the adherence scale. Among 100 in-patients 62 (62%) patients were male and 38 (38%) patients were female. Most of the patients had low adherence among both genders. Patients under age group of 41-60 years were more (58%) in which 46% had low adherence. It was observed that, married patients were more with low adherence (58%) followed by unmarried. When taking account of education of the patient, graduates and above were only 22 patients (22%) but most of them (16% ) had moderate/high adherence. Education of the patients had a significant positive correlation (i.e., p value = 0.0000002) between low adherence and high adherence of patients. This study showed that the adherence to anti-diabetic medications in diabetic patients were very less. It needs to be continuously evaluated in order to reduce complications and improve quality of life of patients.&#x0D; Keywords: Medication adherence, MMAS-8, Uncontrolled diabetes

Prevalence and predictors of diabetes mellitus among persons living with HIV: a retrospective cohort study conducted in 4 public healthcare facilities in KwaZulu-Natal

BackgroundDiabetes mellitus is a chronic non-infectious medical condition which is evident by raised levels of glucose in the blood, because the body cannot produce any or enough of the hormone insulin or use insulin effectively. Diabetes, if not well managed leads to complications such as neuropathy, retinopathy, nephropathy which can be fatal. Some of the factors that predisposes to diabetes include older age, higher body mass index, heredity and hypertension.With the availability of HAART for managing HIV/AIDS infection, life span of persons living with HIV (PLWHIV) has increased significantly. With increased longevity, the aging population of PLWHIV also face chronic diseases such as diabetes in addition to HIV. The burden of both HIV and diabetes is high in South Africa, particularly in KwaZulu-Natal. Nevertheless, the prevalence of diabetes among PLWHIV in KwaZulu-Natal and its predictors is not well understood. Therefore, this study was conducted to determine the prevalence, predictors of diabetes and the outcome of managing diabetes among PLWHIV.MethodsThis retrospective cohort study was conducted in four public health care facilities in KwaZulu-Natal with a total sample size of 1203 after ethical approval and informed consent were obtained. A pretested questionnaire and hospital patient charts were used to collect data. SPSS version 26 was used to analyze the data using descriptive statistics and logistic regression.ResultsThe prevalence of diabetes among PLWHIV was 9%. Just over 47% of those who had diabetes, had uncontrolled blood sugar, with a mean fasting blood sugar (FBS) of 11.7 mmol/L. The predictors of diabetes among PLWHIV were male gender and older age. Male PLWHIV had 65% less chances of having diabetes and those who were between the ages of 18 and 48 years were 88% less probable to have diabetes compared to those who were older than 48 years.ConclusionPublic sector health care facilities in KwaZulu-Natal need to do much more to manage diabetes in PLWHIV in order to prevent diabetic complications and possible negative impact on the outcome of HIV management.

Impact of lockdown on self-care management among patients with type 2 Diabetes Mellitus residing in Lucknow city, India – A cross-sectional study

ObjectiveTo assess the effect of nationwide lockdown and its associated repercussion on the self-care management of Type 2 Diabetes Mellitus (T2D). MethodsResponse from 1406 diabetic patients was collected against a 16 item questionnaire. Data was collected on diabetic self-management practices, behavioral aspects, psychological implications, drug availability and awareness towards the pandemic. Emphasis was on choices made by patients in the absence of guidance from physicians and impact of stress and blood sugar levels on other variables. The data was analyzed using Chi-square tests at P < 0.05. ResultsAbout 27% were under stress, 14.7% and 30.8% reported a change in dietary and sleep pattern. About 83% could not consult a doctor and as a result 13% stopped taking medications. Patients with stress slept less, observed a change in dietary patterns and had uncontrolled blood sugar levels (P = 0.0001). On the contrary those without stress spent time with family and were occupied with a hobby (P = 0.0001). Those with controlled blood sugar levels exercised more and had normal sleep patterns. Fluctuation with doses was observed among those with uncontrolled blood sugar levels in the absence of physicians consultation (P = 0.001). ConclusionEven though majority of study participants were not able to consult their physicians yet nearly 2/3rd were practicing Self-Monitoring of Blood Glucose (SMBG), more than half were exercising regularly, more than 2/3rds continued taking their medications and majority were following appropriate diet pattern. Stress management is a key factor during these times due to its association with other variables.

Diabetes mellitus in Anaesthesia - Optimal Blood Sugar Control in the Perioperative Phase

Uncontrolled high blood sugar can be dangerous for diabetics throughout the perioperative period - in particular, when blood glucose levels exceed a threshold of 250 mg/dl or HbA1c levels are higher than 8.5 - 9%. In such cases, all elective surgery should be withheld to minimize the risk of severe complications. Due to their cardiovascular comorbidities, diabetics are commonly overrepresented in hospitals, tend to require inpatient care for an extended period of time, and suffer from higher mortality rates. In order to reduce negative outcomes, blood glucose levels should be targeted to 140 - 180 mg/dl on intensive care units or during surgery. Current literature suggests that non-critically ill diabetics should be treated with rapid-acting insulin analogues subcutaneously in operating theatres, whereas critically ill patients should receive continuous intravenous insulin infusions using a standardized protocol. In summary, this review can give a hand in dealing with diabetics during the perioperative period and offers guidance in controlling blood sugar levels with the help of oral antidiabetic drugs and insulin.

Predisposition Factors Analysis for Fournier’s Gangrene Defects Closure Complication

Background: Fournier’s gangrene is a rare and rapidly progressive, necrotizing fasciitis affecting the external genitalia and perineum. Based on the case series that have been reported, the incidence rate of this case is 88% with mortality rate of 20%-40%. The study aims to share our policy in managing Fournier’s gangrene and identifying risk factors that can affect the outcome of defect closure.Method: The medical records of 10 patients with Fournier’s gangrene who presented at the Dr. Soetomo Hospital Surabaya from January 2017 to December 2018 were reviewed retrospectively. We analyzed characteristics of the patients, risk factors, methods of defect closure, and case outcome. There are 10 Fournier’s gangrene patients at Dr. Soetomo Academic General Hospital from January 2017 to December 2018. We analyzed the patient’s medical records retrospectively on the patient’s characteristics, risk factors, method of closing Fournier’s gangrene defects, and the final outcome of the case.Results: There were ten men enrolled in the study, and the mean age was 49.3 ± 11.51 years. All patients received broad-spectrum antibiotic therapy, and extensive surgical excision. This study found that diabetes mellitus and uncontrolled patient blood sugar levels, statistically there is no effect on failure of defect closure in Fournier gangrene patients, but clinically, the relative risk value shows that blood glucose levels have a risk factor of 6 times. increasing the incidence of failure to close the Fournier gangrene defect.Conclusions: Fournier’s gangrene is still considered a severe disease with fairly high mortality rate. Early recognition of predisposition factors associated with invasive and aggressive treatment options is very important in efforts to to reduce morbidity.

Chyawanprash as add on to the standard of care in preventing COVID-19 infection among apparently healthy health care workers - A single arm, longitudinal study

Objective: To assess the efficacy and safety of Chyawanprash in preventing SARS-CoV-2 infection among health care personnel working at COVID-19 isolation ward. Setting: A hospital designated as COVID-19 care centre in Delhi, India Participants: Apparently healthy health care workers (HCWs) of age 20 to 60 years who were RT PCR negative and asymptomatic but possibly had exposure to active cases of COVID- 19, with or without co-morbid conditions were included. Pregnant and lactating females, volunteers with malignancy, uncontrolled blood sugar, chronic renal failure, chronic heart failure, hematological disorders, and those on immunosuppressants were excluded from the study. Interventions: Chyawanprash, an Ayurvedic rasayana medicine 12 gm orally with warm water twice daily for 30 days along with standard preventive measures adopted by the institute. Primary Outcome: Incidence of COVID-19 infection confirmed by RT-PCR test. Secondary Outcomes: Evaluation of safety of the study drug through hematological & biochemical investigations and occurrence of any adverse drug reaction or adverse events; number of participants developing any other bacterial, viral or fungal infection during the study period and changes in inflammatory and immune markers. Results: At the end of study period, out of total 50 participants enrolled, two were COVID -19 positive. Incidence rate in similar population in the same study setting prior to commencing (9.71%) and after completing the study period (1.79%) was compared with incidence of COVID-19 during treatment period (1.09%). So, Chyawanprash showed protection rate of 98.91%. It was well tolerated by all the study participants, when administered for 30 days. Conclusions: The infection rate at the hospital dropped significantly following administration of Chyawanprash. As Chyawanprash shows potential of a prophylactic agent against infection by SARS-CoV-2 infection, and is safe when used in the recommended daily dosage, a randomized controlled trial to prove its prophylactic efficacy can be designed on larger sample size.