ABSTRACT The McArthur River unconformity-related uranium deposit, located in the Athabasca Basin of Saskatchewan, Canada, is structurally hosted near the unconformity between Archean to Paleoproterozoic metasedimentary basement and the Proterozoic Athabasca Group sandstones. In this study, the mineralogy and geochemistry of fracture materials within the entire ca. 550 m thickness of the Athabasca Group sandstones and the metasedimentary (host) rocks from the McArthur River area were used to determine the paragenetic sequence and origin of minerals in and near the fractures. Our work sought to determine if the host minerals record elements associated with the uranium deposit at depth and if they could be used to guide exploration (vectoring). Fracture orientations indicate that most are moderately dipping (<50°) and provided permeable pathways for fluid movement within the basin, from below, and through the overlying sedimentary rocks. Many of the fractures and adjacent wall rocks record evidence of multiple distinct fluid events. Seven types of fracture fillings were identified from drill core intersecting the Athabasca Basin and present distinct colors, mineralogy, and chemical features. Brown (Type 1) and pink (Type 7) fractures host paragenetically late botryoidal goethite, Mn oxide minerals, and poorly crystallized kaolinite that formed from relatively recent low-temperature meteoric fluids, as indicated by poor crystallinity and low δ2H values of –198 to –115‰. These minerals variably replaced higher temperature minerals that are rarely preserved on the fractures or in wall rock near the fractures. Hydrothermal alteration associated with the mineralizing system at ca. 200 °C is recorded in assemblages of dickite, well-crystallized kaolinite, and spherulitic dravite in some white and yellow (Type 2) and white (Type 3) fractures, as reflected by the crystal habits and variable δ2H values of –85 to –44‰. Fibrous goethite in white and yellow (Type 2) and black and orange (Type 5) fractures and microfibrous Mn oxy-hydroxide minerals in black (Type 4) fractures also crystallized from hydrothermal fluids, but at temperatures less than 200 °C. White and yellow fractures (Type 2) containing fibrous goethite reflect fracture networks indicative of hydrothermal fluids associated with the mineralizing system during primary dispersion of pathfinder elements and therefore extend the deposit footprint. Brown (Type 1) and pink (Type 7) fractures have low δ2H values in botryoidal goethite and poorly crystallized kaolinite and are indicative of the movement of meteoric waters. Secondary dispersion of elements from the deposit to the surface on some fractures is evidence that fractures are pathways for element migration from the deposit to the surface, over distances exceeding ∼500 m.