Feed Forward Back Propagation artificial neural network (ANN) model utilizing the MATLAB Neural Network Toolbox is designed for the prediction of surface roughness of Duplex Stainless Steel during orthogonal turning with uncoated carbide insert tool. Turning experiments were performed at various process conditions (feed rate, cutting speed, and cutting depth). Utilizing the Taguchi experimental design method, an optimum ANN architecture with the Levenberg-Marquardt training algorithm was obtained. Parametric research was performed with the optimized ANN architecture to report the impact of every turning parameter on the roughness of the surface. The results suggested that machining at a cutting speed of 355 rpm with a feed rate of 0.07 mm/rev and a depth of cut 0.4 mm was found to achieve lower surface roughness with, an increase in the cutting speed and feed rate with the increases of the surface roughness. In addition, an increase in the depth of cut was found to reduces the surface roughness. The outcome of this study showed that ANN is a versatile tool for prediction of surface roughness and may be easily extended with greater confidence to various metal cutting processes.