In recent years, deep learning models have demonstrated remarkable success in various image processing tasks, ranging from object recognition to medical image analysis. However, their performance often degrades in the presence of unseen data or adversarial attacks, highlighting the need for enhancing robustness and generalization. This paper explores innovative approaches to address these challenges, aiming to improve the reliability and applicability of deep learning models in real-world scenarios. The first section of the paper delves into the importance of robustness and generalization in deep learning models for image processing tasks. It discusses the implications of model vulnerabilities, such as overfitting to training data and susceptibility to adversarial perturbations, on the reliability of model predictions. [1] Through a comprehensive review of existing literature, various factors influencing robustness and generalization are identified, including dataset diversity, model architecture, regularization techniques, and adversarial training methods. The paper proposes novel methodologies to enhance the robustness and generalization capabilities of deep learning models. One key approach involves the integration of diverse training data sources, including synthetic data augmentation and domain adaptation techniques, to expose the model to a wider range of scenarios and improve its ability to generalize to unseen data. Additionally, advanced regularization techniques, such as dropout and batch normalization, are explored to mitigate overfitting and improve model generalization. The paper investigates the effectiveness of adversarial training strategies in enhancing model robustness against adversarial attacks. By incorporating adversarially generated examples during training, deep learning models can learn to better resist perturbations and maintain performance under adversarial conditions. Moreover, the paper explores the potential of incorporating uncertainty estimation methods, such as Bayesian neural networks and Monte Carlo dropout, to quantify model uncertainty and improve robustness in uncertain environments. This paper presents a comprehensive investigation into enhancing robustness and generalization in deep learning models for image processing tasks. By addressing key challenges such as overfitting, dataset bias, and adversarial vulnerabilities, the proposed methodologies offer promising avenues for improving the reliability and applicability of deep learning models in real-world scenarios.