Based on relative-distance-measure fuzzy interval arithmetic (RDM-FIA), this paper presents several new concepts for fuzzy functions in fractional granular calculus with Mittag-Leffler (ML) kernels, such as Atangana–Baleanu (AB) fractional granular integrals, AB fractional granular derivatives, and AB Caputo fractional granular derivatives. Then, we present formulas for the fuzzy granular Laplace transform on Caputo fractional granular derivatives, AB fractional granular derivatives, and AB Caputo fractional granular derivatives. In addition to the relationship between AB fractional granular derivatives and AB Caputo fractional granular derivatives established using the granular Laplace transform, new fractional Newton–Leibniz-type formulas for both derivatives and integrals are proved. As applications, we obtain the fundamental solutions for the fuzzy economic models in the framework of Caputo fractional granular derivatives and AB Caputo fractional granular derivatives by utilizing the fuzzy granular Laplace transform. Several graphical explanations are given to show the dynamic behavior of the fundamental solutions. Moreover, we illustrate the advantages of using RDM-FIA to study the mathematical models of uncertain dynamical systems. The results of this study are illustrated using several numerical examples.