• The measurement of hybrid reliability under the non-probabilistic time-variant uncertainties is defined mathematically. • By virtue of the first-passage theory, a new technique of hybrid time-dependent reliability model is conducted. • The new optimization strategy based on hybrid time-dependent reliability is discussed. Structural safety assessment issue, considering the influence of uncertain factors, is widely concerned currently. However, uncertain parameters present time-variant characteristics during the entire structural design procedure. Considering materials aging, loads varying and damage accumulation, the current reliability-based design optimization (RBDO) strategy that combines the static/time-invariant assumption with the random theory will be inapplicable when tackling with the optimal design issues for lifecycle mechanical problems. In light of this, a new study on non-probabilistic time-dependent reliability assessment and design under time-variant and time-invariant convex mixed variables is investigated in this paper. The hybrid reliability measure is first given by the first-passage methodology, and the solution aspects should depend on the regulation treatment and the convex theorem. To guarantee the rationality and efficiency of the optimization task, the improved GA algorithm is involved. Two numerical examples are discussed to demonstrate the validity and usage of the presented methodology.