We present recent advances in harmonic analysis on infinite graphs. Our approach combines combinatorial tools with new results from the theory of unbounded Hermitian operators in Hilbert space, geometry, boundary constructions, and spectral invariants. We focus on particular classes of infinite graphs, including such weighted graphs which arise in electrical network models, as well as new diagrammatic graph representations. We further stress some direct parallels between our present analysis on infinite graphs, on the one hand, and, on the other, specific areas of potential theory, probability, harmonic functions, and boundary theory. The limit constructions, finite to infinite, and local to global, can be used in various applications.