Kidneys are one of the vital organs of body which carry out several important roles in regulating the normal body functions. Its major role is formation of Baul (urine) and execute water and salt balance, and release of hormone. Excess use of antibiotics (chiefly aminoglycosides), NSAIDS and anti-tubercular drugs damage the kidneys. Renal failure is the condition where withholding of metabolic products in response to weakening of function. In recent time its management is by dialysis, kidney transplantation or chemotherapy. This type of treatment is costly and not affordable by everyone. For this solution there are many drugs describe in Unani literature from Mawalide Salasa origin like; plant, mineral and animals that have negligible side effects and easily available their native. The present review attempted to clarify the role of the drug repertoire of the Unani Medicine which are used for the management of amraze kuliya/zofe kuliya scientifically proved useful in treating renal disorders