A compact 4-port coplanar waveguide (CPW) fed ultra-wideband (UWB) multiple-input-multiple-output (MIMO) antenna with enhanced isolation is proposed to operate from 3.66 GHz to 16.61 GHz with 127.78% impedance bandwidth. The proposed antenna system consists of 4 orthogonal arrays of monopole antennas improved by four iterations. The UWB characteristic of the antenna is obtained from an improved monopole antenna fed by CPW. The final MIMO antenna is machined on a Rogers 4003C substrate with dimensions of mm3. The orthogonal arrangement of antennas brings about the polarization diversity and certain isolation of MIMO antennas. Four rows of orthogonal metasurface elements with via holes and the ring of the backplane further improve the isolation between antenna elements in the MIMO system. The MIMO antenna has an impedance bandwidth of 12.95 GHz with dB and good isolation ( dB and dB). In particular, S31 is always less than −25 dB at frequencies greater than 6 GHz. The measured results of MIMO antenna agree with the simulated results. The optimized MIMO antenna has excellent performance in many aspects, such as UWB, compact size, omnidirectional radiation, enhanced isolation and high efficiency, which means that it has application potential in UWB wireless communication systems.