ABSTRACT Prenatal diagnosis of clefts has had a profound benefit in the care of these children. The shock of the surprise appearance, especially the complete bilateral cleft with the protruding premaxilla, was a profoundly disrupting and stressful experience for the family. Prenatal diagnosis, especially when coupled with the option of neonatal surgery, allows calm discussion with the family and a well-thought treatment plan with multiple options that can be implemented at birth. With proper consultation and some before and after photos, parents are put at significant ease. Most are enthusiastic about immediate neonatal repair, which is done within the 1st week of birth. Additional benefits of this include molding of the premaxilla in preparation for closure of the alveolus cleft with calcium bone substitutes obviating presurgical orthopedics. Besides going home with a normal looking child that can even breast feed, the family does not have to be disrupted again with another visit for this surgery at 3 months. Complete unilateral and bilateral clefts can be successfully treated for the most part with two surgeries within 6 months of life. How to cite this article Lazarou SA. Profound Benefits of Prenatal Diagnosis in the Quality of Life and Care of Clefts. Donald School J Ultrasound Obstet Gynecol 2016;10(4):372-375.