Ultrasound Bioeffects Research Articles

Ultrasound-induced orientation of discoid platelets and simultaneous changes in light transmission: preliminary characterisation of the phenomenon.

Discoid platelet suspensions were subjected to ultrasonic fields, in the 1-10 MHz frequency range and at estimated acoustic pressures in the range of 0.05-7.6 X 10(4) Pa. Absolute definition of the acoustic field/pressures was precluded by the small dimensions, and internal reflective surfaces, of the experimental configurations employed. Direct microscopy revealed platelet flow, in patterns consistent with theory for ultrasonically induced streaming. This ultrasonic effect was presumed to be accompanied by platelet orientation since it could be quantitated by simultaneous light transmission measurements. The preliminary characterisation of this phenomenon, defined as ultrasound induced light transmission change (USILTC) is reported, and indicates that it may be readily quantitated in a reproducible manner, but which shows a complex relationship both to pressure and frequency. In addition, qualitative characteristics of the response traces are apparent under certain conditions, particularly 5 MHz above 1 X 10(4) Pa, and may relate to platelet viability. Preliminary evidence is provided and discussed, which suggests that USILTC may be a useful model for studying certain ultrasound bioeffects, and may be a useful tool for indirectly assessing platelet morphology and viability for quality assurance purposes.

Ultrasound Bioeffects

EchocardiographyVolume 4, Issue 2 p. 89-99 Ultrasound Bioeffects JOSEPH B. PORDER M.D., JOSEPH B. PORDER M.D. Center for Biomedical Ultrasound and Department of Medicine, University of Rochester, Rochester, New York, and Mt. Sinai Medical Center, New York, New York.Search for more papers by this authorKATHLEEN N. PORDER M.D., KATHLEEN N. PORDER M.D. Center for Biomedical Ultrasound and Department of Medicine, University of Rochester, Rochester, New York, and Mt. Sinai Medical Center, New York, New York.Search for more papers by this authorRICHARD S. MELTZER M.D., PH.D., Corresponding Author RICHARD S. MELTZER M.D., PH.D. Center for Biomedical Ultrasound and Department of Medicine, University of Rochester, Rochester, New York, and Mt. Sinai Medical Center, New York, New York.Cardiology, Box 679, University of Rochester Medical Center, Rochester, NY 14642.Search for more papers by this author JOSEPH B. PORDER M.D., JOSEPH B. PORDER M.D. Center for Biomedical Ultrasound and Department of Medicine, University of Rochester, Rochester, New York, and Mt. Sinai Medical Center, New York, New York.Search for more papers by this authorKATHLEEN N. PORDER M.D., KATHLEEN N. PORDER M.D. Center for Biomedical Ultrasound and Department of Medicine, University of Rochester, Rochester, New York, and Mt. Sinai Medical Center, New York, New York.Search for more papers by this authorRICHARD S. MELTZER M.D., PH.D., Corresponding Author RICHARD S. MELTZER M.D., PH.D. Center for Biomedical Ultrasound and Department of Medicine, University of Rochester, Rochester, New York, and Mt. Sinai Medical Center, New York, New York.Cardiology, Box 679, University of Rochester Medical Center, Rochester, NY 14642.Search for more papers by this author First published: March 1987 https://doi.org/10.1111/j.1540-8175.1987.tb01326.xCitations: 8 Supported in part by Grant-in-Aid 82–1048 from the American Heart Association, Dallas, Texas and a Grant-in-Aid and Established Fellowship from the New York Heart Association. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume4, Issue2March 1987Pages 89-99 RelatedInformation

Research in Ultrasound Bioeffects: A Public Health View

ABSTRACT: A review is made of the human and laboratory studies of bioeffects of ultrasound. These include developmental, hematological, neurological, behavioral, immune and genetic effects after exposures to ultrasound in doses now used clinically. Some problems with the human and laboratory studies are described. It is questioned whether curves of intensity/exposure times can be drawn to delineate safe usage of ultrasound without more data on long‐ and short‐term effects in animals and humans.