Metal components with functionally organized microstructures for specific applications are emerging thanks to hybrid additive manufacturing (AM). The customization of these high value components accentuates the need for nondestructive methods to characterize their microstructural functional patterns. Nondestructive evaluation (NDE) methods that are economical, fast, energy efficient, and easy to integrate into routine component inspections are preferred. Most importantly, NDE methods must be sensitive to changes in the microstructure such that regions that do not satisfy the design requirements (i.e. out-of-spec regions) can be detected. In this work, ultrasonic NDE methods grounded in diffuse backscatter modeling were used to detect and quantify spatial property variations resulting from a hybrid AM process. The manufacturing process coupled directed energy deposition (DED) with milling in a cyclical manner. These methods were successfully implemented to evaluate the microstructural uniformity of Ti6Al4V samples as well as to make comparisons across an ensemble of samples manufactured with identical parameters. Out-of-spec regions were mapped with respect to the sample geometry on a layer-by-layer basis. The results of this work are expected to inform future NDE strategies for both research and practitioner contexts, and limitations are discussed.