The influences of surface integrity on the fatigue performance of in-situ 6 wt% TiB2/2024Al composite treated by ultrasonic deep rolling (UDR) were comprehensively investigated with both experiments and simulations. Results reveal that only a single pass of UDR treatment can impressively reduce the surface roughness of the fine-turned specimens by 94 %. Moreover, axial compressive residual stress (RSc) larger than −400 MPa and strain hardening (SH) higher than 50 % were obtained on the surface. The comprehensive effect of these surface integrity improvements has enhanced the fatigue limit by 22 %, extended the fatigue life by 10∼20 times, and expanded the safe region in the Goodman-Haigh graph by 14.6 %. More importantly, UDR significantly dispersed the TiB2-particle aggregates in the composite surface, which provided the possibility of improving the surface comprehensive mechanical properties of particles reinforced metal matrix composites (PRMMCs) through a simple and convenient mechanical way.