Ultrasmall Nanocrystals Research Articles

Multiscale Structural Engineering of Sulfur/Carbon Cathodes Enables High Performance All-Solid-State LiS Batteries.

Constructing all-solid-state lithium-sulfur batteries (ASSLSBs) cathodes with efficient charge transport and mechanical flexibility is challenging but critical for the practical applications of ASSLSBs. Herein, a multiscale structural engineering of sulfur/carbon composites is reported, where ultrasmall sulfur nanocrystals are homogeneously anchored on the two sides of graphene layers with strong SC bonds (denoted as S@EG) in chunky expanded graphite particles via vapor deposition method. After mixing with Li9.54 Si1.74 P1.44 S11.7 Cl0.3 (LSPSCL) solid electrolytes (SEs), the fabricated S@EG-LSPSCL cathode with interconnected "Bacon and cheese sandwich" feature can simultaneously enhance electrochemical reactivity, charge transport, and chemomechanical stability due to the synergistic atomic, nanoscopic and microscopic structural engineering. The assembled InLi/LSPSCL/S@EG-LSPSCL ASSLSBs demonstrate ultralong cycling stability over 2400 cycles with 100% capacity retention at 1 C, and a record-high areal capacity of 14.0mAhcm-2 at a record-breaking sulfur loading of 8.9mgcm-2 at room temperature as well as high capacities with capacity retentions of ≈100% after 600 cycles at 0 and 60°C. Multiscale structural engineered sulfur/carbon cathode has great potential to enable high-performance ASSLSBs for energy storage applications.

Universal Solid-Phase Seed-Mediated Synthesis of Monodisperse and Ultrasmall L10-PtM Intermetallic Nanocrystals

Intermetallic compounds have emerged as a class of promising electrocatalysts for fuel cells; however, it is still a great challenge to synthesize monodisperse and small intermetallic phases by an economical and scalable method. Herein, we demonstrate a generally applicable solid-phase seed-mediated diffusion strategy for controllable synthesis of ordered L10-PtM (M = Mn, Fe, Co, and Zn) nanoparticles, where the preprepared monodispersed Pt seeds are used as the growth sites. The freeze-drying procedure produces monodisperse metal precursors on Pt/C, and the subsequent annealing process in a H2/Ar atmosphere obtains highly dispersed and ultrasmall PtM intermetallic nanocrystals (∼3 nm) on carbon supports. More importantly, such a strategy is also applicable to the preparation of a high-loaded PtMn intermetallic catalyst (50 wt %). Taking PtMn/C catalysts as examples, we illustrate their synthetic details and formation mechanism of the desired ordered phases. This approach eliminates the need for energy-consuming filtering and washing procedures, which makes it very promising for large-scale production.

A multifunctional nanotheranostic agent based on Lenvatinib for multimodal synergistic hepatocellular carcinoma therapy with remarkably enhanced efficacy

Lenvatinib (LT), a first-line molecular targeted therapeutic drug for hepatocellular carcinoma (HCC), has been replacing the status of Sorafenib (SF) as the clinically preferred and irreplaceable treatment for a decade. To overcome the low drug utilization and limited single efficacy of LT, ultrasmall copper sulfide nanocrystals (Cu2-xS NCs), and ultrasmall gold nanoparticle (AuNPs) were evenly wrapped into galactosamine conjugated poly(lactide-co-glycolide) (PLGA) as the drug delivery nanoparticles (CAL@PG) by nanoprecipitation. The CAL@PG NPs exhibited excellent stability under physiological conditions, whereas they released LT rapidly in the unique tumor microenvironment (TME) and high temperature, which could be provided by the near-infrared-II (NIR-II) photothermal effect of Cu2-xS NCs. Moreover, the temperature elevation, regenerated hydrogen peroxide (H2O2), and lower pH of TME could substantially boost the reaction potency of copper Fenton-like chemistry. More importantly, this combined therapy significantly improved the efficacy of LT, provided a multifunctional LT delivery system, and enriched the nanoparticle-augmented multimodal synergistic HCC therapy modality.

Immobilizing ultrasmall Pt nanocrystals on 3D interweaving BCN nanosheet-graphene networks enables efficient methanol oxidation reaction.

Currently, the state-of-the-art anode catalysts employed in direct methanol fuel cells (DMFCs) consist of nanosize Pt dispersed on a carbonaceous support; however, the relatively weak Pt-carbon interfacial interactions severely affect their overall electrocatalytic activity and service life. Herein, we demonstrate a convenient and robust stereo-assembly strategy for the efficient immobilization of ultrasmall Pt nanocrystals on 3D interweaving porous B-doped g-C3N4 nanosheet-graphene networks (Pt/BCN-G) by combining thermal annealing and solvothermal processes. This delicate configuration endowed the resulting hybrid nanoarchitecture with unusual textural merits, including 3D crosslinked porous skeletons, well-separated ultrathin nanosheets, rich B and N species, homogeneous Pt dispersion, stable heterointerface, and high electrical conductivity. Consequently, the 3D Pt/BCN-G nanoarchitecture with an optimized composition exhibited a large electrochemically active surface area of up to 121.2 m2 g-1, high mass activity of 1782.2 mA mg-1, superior poison tolerance, and excellent cycling stability towards the electrooxidation of methanol, all of which exceeded that of the reference Pt/graphene, Pt/BCN, Pt/carbon nanotube, Pt/carbon black, and Pt/g-C3N4 catalysts.

Vacancy-Mediated Z-Scheme Heterostructure in SnO2-Decorated Spinel In3-xS4 with Boosted Photocatalytic Activity.

The widespread application of dyes and heavy metals causes increasing environmental pollution. One effective way to mitigate environmental pollution is to use semiconductor photocatalysts for redox purification of pollutants. Heterostructured photocatalysts can reduce the electron-hole recombination rate and improve light utilization. In this work, a novel SnO2/In3-xS4 composite with oxygen vacancy defect-mediated Z-scheme heterostructure is constructed for the first time by a one-pot method, in which SnO2 ultrasmall nanocrystals are decorated on nanopetals of flower-like In3-xS4. Material analyses show that the as-built three-dimensional hierarchical architecture is able to essentially increase the specific surface area and thus the active sites of the products. More importantly, the formation of Z-scheme heterojunction between the oxygen vacancy-induced SnO2 defect level and the In3-xS4 band structure not only promotes the separation of photogenerated charges but also makes them more reactive. Through the optimization of the composition ratio between the two phases, the visible-light-driven photocatalytic reaction rates of rhodamine B degradation and Cr(VI) reduction for the developed SnO2/In3-xS4 composite photocatalyst are 12.8 and 6.3 times of bare In3-xS4 and 32.0 and 76.0 times of bare SnO2, respectively. This work should provide a promising implication for designing new high-performance composite photocatalysts.

Platinum nanoparticle-graphene quantum dot nanocage as a promising Schottky heterojunction electrocatalyst for electrochemical detection of vanillin in baby milk powder

Facile synthesis of platinum nanocrystal and its improvement in catalytic activity still face great challenges. The paper reports one strategy for synthesis of platinum nanoparticle-serine-functionalized and boron-doped graphene quantum dot composite (Pt-Ser-B-GQD). The Ser-B-GQD was prepared by pyrolysis of serine, boric acid and citric acid at 180 °C for 3 h and then reacted with chloroplatinic acid to form platiunm nanocrystal. The resultant Pt-Ser-B-GQD offers a nanocage-like structure composing of tiny graphene sheets connecting many ultrasmall platinum nanocrystals with an average particle size of 8.2 ± 0.32 nm. The combination of Pt nanocrystal with Ser-B-GQD results in the formation of Schottky heterojunction at the interface. The unique structure achieves to an improved catalytic activity. Pt-Ser-B-GQD was further used as Schottky heterojunction electrocatalyst for the construction of electrochemical sensor for the detection of vanillin. Because of excellent electrochemical properties, the sensor based on Pt-Ser-B-GQD exhibits a high sensitivity for electrochemical detection of vanillin. Differential pulse voltammetric peak current will increase linearly with increasing vanillin concentration in the range of 1 × 10−9-1 × 10−4 M with the detection limit of 2.8 × 10−10 Μ (S/N = 3). The proposed analytical method provides advantage of sensitivity, selectivity and reproducibility and was successfully applied in the detection of vanillin in baby milk powder.

Synthesis of ultra-small NaA zeolite nanocrystals at near room temperature

The NaA zeolite nanocrystalline aggregates composed of 6 nm ultra-small were synthesized for the first time by refluxing at near room temperature and atmospheric pressure. NaA zeolite samples had been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and N2 adsorption-desorption isotherms. The XRD of the obtained samples at different synthesis temperatures demonstrated that their crystallinity was high. Furthermore, the SEM images of NaA zeolite synthesized at 30, 40 and 60 °C showed that its particle sizes were 130, 130 and 180 nm, respectively. Moreover, the TEM images confirmed that the NaA zeolite aggregates synthesized at 40 and 60 °C consisted of ultra-small crystals with a size of 6 nm, while the NaA zeolite synthesized at 30 °C was a single crystal. Compared with the previously reported synthetic zeolite crystals, the use of a reflux system under atmospheric pressure in this study not only synthesized the ultra-small zeolite nanocrystals (6 nm) with large specific surface area, but also avoided many safety issues brought by traditional synthesis methods under high autogenous pressure. Therefore, this study provides a precise and safe synthetic method for the development of ultra-small zeolite nanocrystals. Moreover, the large specific surface area makes them have great potential for development.

Hierarchical TiO2 microspheres supported ultrasmall palladium Nanocrystals: A highly efficient catalyst for Suzuki reaction

A hierarchical titanium dioxide microspheres-supported palladium catalyst (Pd/TiO2-350) was prepared and characterized using BET, XRD, XPS, SEM, EDX, and TEM analyses. An ICP-OES analysis of Pd/TiO2-350 further confirmed the successful Pd immobilization on TiO2 with a palladium loading of 0.1 mmol g−1. Pd/TiO2-350 efficiently catalyzed the Suzuki-Miyaura reaction of aryl iodides with arylboronic acids to give the corresponding biaryl derivatives in good to excellent yields. After the reaction, the catalyst was recovered by centrifugation and reused three times without significant loss of its catalytic activity. Moreover, the loading of palladium species further decreased to 0.001 mol%, and the total turnover number and turnover frequency of the catalyst reached as high as 99 000 and 0.57 s−1, respectively.

Facile fabrication of MoS2 nanocrystals confined in waste leather derived N, P co-doped carbon fiber for long-lifespan of sodium/potassium ion batteries

Due to its slow kinetics and complicated multiphase development during cycling, developing anode materials for sodium/potassium-ion batteries (SIBs/PIBs) with high-rate and long-cycle simultaneously is still crucial and challenging. Additionally, the application of abundantly available, waste biomass to energy storage device has become a research hotspot. Herein, using waste leather as the adsorbent and bioreactor, we facilely fabricating the leather derived N/P co-doped carbon fiber composite with MoS2 nanocrystals after sulfuration treatment. Due to the intrinsic advantage of texture and component of collagen fiber, the ultrasmall MoS2 nanocrystals are evenly embedded with N/P co-doped carbon fibers. As expected, the MoS2/NP-C anode shows enhanced sodium/potassium storage capacity. It exhibits a high specific capacity (368 mAh g−1 at 0.2 A g−1) for PIBs and amazing long-term cycling qualities (241 mAh g−1 at 1 A g−1 even after 2500 cycles) for SIBs. This work provides further insight into the application of waste biomass for fabricating nanocomposite in energy storage.

(Digital Presentation) Controllable Preparation of Ultrasmall Pt-Based Intermetallic Nanocrystals Via Atomic Layer Deposition for Hydrogen Fuel Cell

The cost and endurance anxiety about proton exchange membrane fuel cells (PEMFCs) has prompted the rapid development of platinum-based (Pt-based) oxygen reduction electrocatalysts towards smaller particle sizes, higher durability and alloying. However, well-balanced these advanced trends by a simple approach is difficult in practice, because the existing solutions are problematic in removing the protective organic coating or oxide shell that preventing the high-temperature agglomeration of Pt-based nanocrystals, or broadening the size range of Pt-based nanocrystals which caused by the heterogeneous distribution of heteroatom anchor points on supports. With a self-developed strategy that based on the atomic layer deposition (ALD), we have addressed these problems in two aspects. One is directly loading size and distribution controllable Pt nanocrystals on diverse supports, and another is indirectly depositing easily removed ultra-thin metal oxide coating with dual functions on prefabricated ultrasmall Pt nanocrystals to restrain their sintering effect during high temperature ordering. By controlling the temperature and pulse time of ALD, we successfully synthesized ultrasmall (< 2 nm) Pt nanocrystals on surface inactive TiC nanoparticles and nanowires. These two new electrocatalysts exhibited comparable oxygen reduction activity and durability on par with commercial Pt/C with lower Pt loading. And using this strategy, about 1 nm ZnO coating on Pt nanocrystals was performed to construct uniform PtZn intermetallic nanocrystals with the ultrasmall size of 2.50 ± 0.65 nm and excellent stability for oxygen reduction reaction. The mass activity of PtZn intermetallic nanocrystals reaches to 0.60 A mgPt -1 at 0.9 V (6 times than commercial Pt/C) and only 13 mV decrease of half-wave potential after 30000 cycles of accelerated durability testing rivaling the most recently reported PtZn catalysts. Ultrasmall sizes and excellent features of our Pt and Pt-based intermetallic nanocrystals are all attributed to the accurate control of ALD and could be a promising method applying to other Pt-based intermetallic nanocrystals.

Rational design of ultrathin Mo2C/C nanosheets decorated on mesoporous hollow carbon spheres as a multifunctional sulfur host for advanced Li-S batteries

Developing sulfur hosts with reasonable structure and effective catalyst is essential for lithium-sulfur (Li-S) batteries. Herein, a novel multifunctional sulfur host composed of hollow carbon spheres with mesoporous channels (MHCS) coupled with few ultrathin Mo2C/C nanosheets embedded with Mo2C nanocrystals ([email protected]2C/C) has been prepared via one-pot self-assembly and in-situ grown strategies. The Mo2C/C nanosheets with heterostructure can shorten the electron/ion transport path, and ultra-small Mo2C nanocrystals with abundant active sites contribute to enhancing chemical adsorption towards polysulfides and propel their conversion. Meanwhile, the MHCS facilitates physical adsorption towards polysulfides, effective sulfur/electrolyte permeation, fast electron/ion transportation, and sufficient buffering for volume change. Given these, the multifunctional [email protected]2C/C-S cathode demonstrates an initial specific capacity of 1316.8 mAh g−1 at 0.1 C and outstanding cycling stability with an average capacity decay rate of 0.045 % for 500 cycles at 0.5 C. Moreover, [email protected]2C/C-S cathode with high areal sulfur loading of 4.5 mg cm−2 can deliver a high initial discharge specific capacity of 797.4 mAh g−1, and a reversible capacity of 542.7 mAh g−1 after 500 cycles at 0.5 C. It is expected this work could provide a new perspective to the rational design of sulfur hosts for Li-S batteries with enhanced performance.

Study on luminescence quenching of ultra-small silicon nanocrystals due to boron doping

The doping effect and mechanism on optical property of Si nanocrystals is particularly an interesting issue in order to further broaden their applications in the next generation of electronic and optoelectronic devices. A quenching of photoluminescence in B-doped Si nanocrystals was reported before and there is no consensus on the mechanism. Herein, we fabricate boron-doped Si nanocrystals/SiO2 multilayers with the ultra-small dot sizes near 3.0 nm. It’s found B dopants exhibit a low doping efficiency in ultra-small Si nanocrystals, and are mainly located at the surfaces regions. Electron spin resonance results manifest B dopants lead to defects in Si nanocrystals/SiO2 multilayers, which transform from Pb centers to EX centers. The EX centers, rather than Auger recombination, cause the reduction on the intensities and lifetimes of 840 nm near-infrared emission. Our results give an insight into luminescence quenching of ultra-small Si nanocrystals due to boron doping.

A highly efficient SAPO-34 catalyst for improving light olefins in methanol conversion: Insight into the role of hierarchical porosities and tailoring acid properties based on in situ NH3-poisoning

Hierarchical SAPO-34 zeolites with tunable porosity were hydrothermally synthesized by modulating the Si/Al molar ratios of the gel precursors, and the morphologies of SAPO-34 crystals gradually evolve from well-dispersed ultra-small nanocrystals to compactly polycrystalline aggregates, and to analogous polycrystallinites but adhered with minute amorphous debris by increasing the Si/Al ratio ranging from 0.20 to 0.67. The catalytic tests during methanol-to-olefins (MTO) reaction indicate that the Hier-SAPO-34-0.20 (Si/Al = 0.20) catalyst constructed by loosely nano-sized crystals centered at 50 nm presents prominent catalytic performances with about 2.5 times prolonged catalytic longevity and around 10 % improvement for the selectivity toward light olefins (ethylene and propylene) as compared to a reference catalyst. More interestingly, when Hier-SAPO-34-0.20 catalyst was in situ pretreated with NH3 flowing, the selectivity of light olefins can be greatly increased by 18.1 % at the initial stage and the corresponding even selectivity with time-on-stream can be elevated by 6.9 %. It founds that in situ NH3-poisoned catalysts with improved light olefins selectivity are also suitable for ZSM-5 zeolite. These results reveal that the weakened strong acid sites modified by NH3-poisoning play a pivotal role in suppressing the undesired hydrogen transfer reactions and thus giving a high selectivity for light olefins. This work highlights the importance of acidity fine-tailoring by in-situ NH3-poisoning strategy on hierarchical zeolites for the improvement of light olefin selectivity, which would be valuable guidance for industrial applications.

Nanoconfinement Synthesis of Ultrasmall Bismuth Oxyhalide Nanocrystals with Size‐Induced Fully Reversible Potassium‐Ion Storage and Ultrahigh Volumetric Capacity (Adv. Funct. Mater. 27/2022)

Nanoconfinement Synthesis In article number 2201352, Yuxi Xu and co-workers develop a general nanoconfinement strategy to fabricate ultrasmall bismuth oxyhalide nanocrystals with size-induced full reversible potassium-ion storage mechanism and ultrahigh electrochemical capacity.

Ultrasmall Cu Nanocrystals Dispersed in Nitrogen-Doped Carbon as Highly Efficient Catalysts for CO2 Electroreduction.

The electroreduction of carbon dioxide (CO2) to a liquid product is a viable method for establishing an artificial carbon cycle. Unfortunately, most electrocatalysts' low efficiency and instability prevent them from being used in practical applications. In the current study, we developed ultrasmall Cu nanocrystals embedded in nitrogen-doped carbon nanosheets (Cu/NC-NSs) for selective CO2 electroreduction by adjusting the potential. Cu/NC-NSs had 43.7 and 63.5% Faradaic efficiencies for the synthesis of ethanol and formate with applied potentials of -0.37 and -0.77 V vs reversible hydrogen electrode (RHE) using a flow cell architecture, respectively. Moreover, these Cu/NC-NSs show a steady catalytic performance up to 16 h. Density functional theory (DFT) calculations were performed to investigate the reaction mechanism. Furthermore, the synergistic effect formed by nitrogen-doped carbon and highly dispersed copper atoms led to their excellent performance in CO2 electroreduction.

Nanoconfinement Synthesis of Ultrasmall Bismuth Oxyhalide Nanocrystals with Size‐Induced Fully Reversible Potassium‐Ion Storage and Ultrahigh Volumetric Capacity

AbstractBismuth oxyhalide (BiOX, X = Cl, Br, I) nanomaterials have attracted enormous attention because their unique layered structure and nano‐size effect endows them with fascinating physicochemical properties and wide application potential. However, synthesis of ultrasmall BiOX nanocrystals with sizes down to sub‐10 nm remains a considerable challenge and the investigation of such ultrasmall BiOX nanocrystals in alkali‐metal ion batteries have not yet been explored so far. The fabrication of ultrasmall BiOX nanocrystals with an average size of 6 nm on reduced graphene oxide by a versatile nanoconfinement strategy is reported here. The obtained ultrasmall BiOCl nanocrystals‐based monolithic composites are evaluated as free‐standing anodes for potassium‐ion batteries (PIBs) and exhibit the highest reversible capacity of 521 mAh g−1 at 0.05 A g−1 among all reported Bi‐based PIB anodes and ultrahigh volumetric capacity of 1148 mAh cm‐3, along with excellent rate capability (205 mAh g−1 at 5 A g−1 ) and extraordinary cycling stability with 94.7% capacity retention after 3000 cycles. More importantly, a fully reversible potassium storage mechanism of BiOCl (BiOCl ↔ Bi ↔ K3Bi) induced by the ultrasmall nano‐size effect is revealed for the first time by detailed characterizations, providing new fundamental insights for boosting the electrochemical performance of nanostructured materials.

Controlled synthesis of hierarchically porous SAPO-34 zeolites with tailored crystal size and morphology

A series of hierarchically porous SAPO-34 zeolites with tunable crystal sizes varying from 40 to 200 nm were synthesized with different morphologies from well-dispersed ultra-small nanocrystals to compact spherical-like polycrystalline aggregates by only changing the Si/TEAOH (TEAOH: tetraethylammonium hydroxide) molar ratios in the gel precursors without using any meso-templates. The hierarchical samples were systematically characterized by XRD, FT-IR, SEM, TEM, XRF, 29Si MAS NMR spectra and N2 adsorption–desorption. It reveals that hierarchical SAPO-34 nanocrystals with high crystallinities, larger external surface areas (61 – 125 m2/g) and mesopore volumes (0.15 – 0.29 cm3/g) were obtained under current synthesis condition.

Synthesis of beta nanozeolite aggregates with hierarchical pores via steam-assisted conversion of dry gel and their catalytic properties for Friedel-Crafts acylation

Modulation of the porosity and acidity of zeolites is a very attractive subject for designing highly efficient solid-acid catalysts. In this work, Beta nanozeolite aggregates with hierarchical porous structure were synthesized via steam-assisted conversion (SAC) of dry gel in presence of seeds and a cationic polymer of polydiallyldimethylammonium chloride (PDAD). The influence of various synthesis parameters, such as the alkalinity, the contents of PDAD and zeolite seeds, and the crystallization conditions (temperature, water/dry gel ratio and time) on the formation of Beta zeolites was studied by combining a variety of characterization techniques. The SAC-synthesized Beta zeolites (S-Beta) are assembled from ultra-small nanocrystals around 10 nm to form self-sustaining micron-sized zeolitic aggregates, and possess abundant interconnected mesopores and relatively mild acidity. Compared with the conventional Beta zeolite, S-Beta aggregates show much higher catalytic activity for the Friedel-Crafts acylation of anisole with acetic anhydride. The excellent catalytic performance of S-Beta should be mainly attributed to the enhanced mass transport ability for reagents as well as the mild acidity that can avoid the rapid deactivation of the catalyst under the test conditions.

A simple two-step strategy to synthesize defect-rich MoS2 nanocrystals for enhanced electrochemical hydrogen evolution

MoS2 based materials are considered the most reliable alternative catalysts for the hydrogen evolution reaction (HER), where engineering of active sites has emerged as an acceptable approach to tune their HER activity. In this approach, the dispersion of bulk MoS2 in the aqueous phase was increased with a surfactant (sodium dodecyl sulfate), which reduced the exfoliation time and enhanced the exfoliation ability to produce layered MoS2 nanosheets. During the hydrothermal treatment, the nanosheets were further scissored into small nanocrystals. Nanocrystals have attractive properties with stable dispersion and high-water solubility. Our method provides a scalable, eco-friendly, easy, and low-cost strategy for designing other HER catalysts. Such ultra-small MoS2 nanocrystals with rich Mo vacancies were used as catalysts for HER, which showed excellent electrocatalytic activity with a low overpotential (95 mV) and small Tafel slope (41 mV/dec) in 0.5M H2SO4 electrolyte. The design and synthesis of the HER catalyst in this work presents a promising path for preparing active and stable electrocatalysts to replace costly metal-based catalysts for hydrogen production.

Localized NIR-II laser mediated chemodynamic therapy of glioblastoma

The effectiveness of most glioblastoma (GBM) therapeutic agents is hindered by poor blood-brain-barrier (BBB) penetration. Moreover, these therapeutic agents cannot target GBM even if they cross the BBB, resulting in serious brain toxicity. Here, an in situ strategy to elicit chemodynamic therapy (CDT) of orthotopic GBM using biomimetic CuFeSe2-LOD@Lipo-CM (CLLC) nanocatalysts which are composed of ultrasmall CuFeSe2 nanocrystals (CFS), lactate oxidase (LOD), and liposome containing GBM cell membrane proteins (Lipo-CM), is reported. The embedding of GBM cell membrane proteins allows CLLC nanocatalysts to penetrate partly disrupted BBB and precisely target GBM due to their excellent homologous targeting and immune escaping abilities. The oxidization of intratumoral lactic acid to H2O2 and pyruvate by LOD leads to the elevation of in situ H2O2 content, providing self-supplied H2O2 for CDT. Meanwhile, the nanocatalysts can initiate Cu+ based Fenton-like reaction to convert the H2O2 into highly harmful •OH. The skull above the orthotopic GBM was removed to rescue the loss of NIR-II laser energy. Then, based on high photothermal conversion efficiency of the nanocatalysts, PA imaging-guided NIR-II laser irradiation on brain of mice post-craniectomy can induce in situ mild hyperthermia and enhanced localized CDT of orthotopic GBM with negligible brain toxicity. These results show that this biomimetic nanocatalyst can achieve the localized CDT enhanced by the LOD and NIR-II laser, which could be an alternative treatment for GBM.