Nucleation of lithium sulfide (Li2S) induced by electrocatalysts plays a crucial role in mitigating the shuttle effect. However, short-chain polysulfides on electrocatalysts surfaces tend to re-dissolve into electrolytes, delaying Li2S supersaturation and its nucleation. In this study, we draw inspiration from the ribosome-driven protein synthesis process in cells to prepare ultrasmall nitrogen-doped MoS2 nanocrystals anchored on porous nitrogen-doped carbon networks (N-MoS2-NC) electrocatalysts. Excitedly, the ex-situ SEM demonstrates that ribosome-inspired N-MoS2-NC electrocatalysts induce early nucleation and rapid growth of three-dimensional Li2S during discharge. Theoretical calculations reveal that the Li-S bond length in N-MoS2-Li2S(100) is shorter, and the corresponding interfacial formation energy is lower than in MoS2-Li2S(100). This accelerated conversion of lithium polysulfides to Li2S can enhance the utilization of active substances and inhibit the shuttle effect. This study highlights the potential of ribosome-inspired N-MoS2-NC in improving the electrochemical stability of Li-S batteries, providing valuable insights for future electrocatalyst design.