The relationship between the microstructure and mechanical properties of alloy 718 was investigated for two discs centrifugally cast at 50 and 200 rpm and given a duplex age heat treatment. The results of mechanical property tests at temperatures from 426 to 649 °C showed that the tensile yield and ultimate strength levels of both castings were similar. However, the creep-rupture properties were considerably enhanced for the casting produced at 200 rpm. Comparison of the radial and transverse creep properties of each disc indicated that creep life was generally independent of orientation, but ductility was greatest for specimens oriented transverse to the radial direction of the casting. Fatigue crack propagation performance was not greatly influenced by orientation or mold speed parameters and was comparable to wrought alloy 718 when compared on the basis of stress intensity factor range. The centrifugal casting process was found to produce a homogeneous microstructure free of porosity but with the expected segregation of solute alloying elements to Laves and carbide phases. The effect of the as-cast microstructure on the mechanical behavior and the potential influence of hot isostatic pressing to improve the microstructure are discussed.