Ulin General Hospital Research Articles

Correlation Between RET-He and Quality of Life in Chronic Kidney Disease Patients with Routine Hemodialysis: A Study at Ulin General Hospital Banjarmasin

Background: The 2018 Riskesdas report revealed that the incidence of chronic kidney disease (CKD) affects 0.38% of Indonesia’s population. Anemia frequently complicates CKD, especially in patients undergoing regular hemodialysis. Reticulocyte hemoglobin equivalent (RET-He) assesses hemoglobin content in reticulocytes, indicating iron availability for erythropoiesis in the bone marrow. CKD significantly impacts patients' socio-economic status, heightening morbidity and mortality while diminishing quality of life. The relationship between RET-He and the quality of life in CKD patients on routine hemodialysis remains unclear. Objective: To investigate the correlation between RET-He and quality of life in CKD patients undergoing routine hemodialysis. Methods: A cross-sectional observational analytical study with data from medical records of CKD patients receiving routine hemodialysis between October 1st and October 30th, 2021. The Spearman correlation test was used for analysis. Results: This study included 92 patients, consisting of 40 males and 52 females, with a median age of 50 years and RET-He values at 31. Quality of life metrics included physical function (800, range: 0-1000), physical limitations (300, range: 0-400), body pain (175, range: 75-255), general health (475, range: 225-600), vitality (320, range: 200-400), social function (175, range: 75-200), emotional limitations (300, range: 100-300), and mental health (380, range: 160-500). The correlation analysis revealed no significant relationships: physical function (p=0.359), physical limitations (p=0.813), body pain (p=0.373), general health (p=0.547), vitality (p=0.616), social function (p=0.828), emotional limitations (p=0.482), and mental health (p=0.136). Conclusion: There is no significant correlation between RET-He levels and the quality of life in CKD patients undergoing regular hemodialysis.

Linear measurement of condyles in edentulous patients with Kennedy classification based on panoramic radiographs

Objectives: This research is aimed to determine the value of linear measurement of the condyle position in partial edentulous patients of Kennedy classification based on panoramic radiographs at Ulin General Hospital and Gusti Hasan Aman Oral and Dental Hospital. Materials and Methods: This research is a descriptive-analytic study with a cross-sectional study design. The population used in the study is a digital panoramic radiograph from the Radiology Installation of Ulin General Hospital and Gusti Hasan Aman Oral and Dental Hospital from January 2018 - January 2024 database. Condyle linear measurement landmarks used are anterior joint space, superior joint space, and posterior joint space, according to the research of Ikeda and Kawamura (2013). Results: The results showed that the largest AJS value is the Kennedy Class I and the smallest is the Kennedy Class IV. The largest SJS value is the Kennedy class III and the smallest is the Kennedy class IV. The largest PJS value is Kennedy class II and the smallest is Kennedy class I. Based on gender, men's joint space value is bigger than women's. However, a significant difference was found in the PJS value of Kennedy class I patients, whose value for men is smaller than that of women. Conclusion: The condyle linear measurement of partially edentulous patients based on Kennedy classification Class I, II, III, IV has an abnormal condyle position and has experienced disc displacement with reduction.

The Association between Coagulation Parameters, C-Reactive Protein, D-Dimer and In-Hospital Mortality of Covid-19 Patients with Suspected Pulmonary Embolism

COVID-19 is a respiratory disease with severe cardiovascular complications, one of them is pulmonary embolism (PE). Studies have shown many contributing factors related to mortality of hospitalized COVID-19 patients that developed pulmonary embolism. This study aimed to find the association between coagulation parameters (PT and APTT), C-reactive protein (CRP), and D-dimer with in-hospital mortality of COVID-19 patients with suspected PE. COVID-19 patients in Ulin General Hospital Banjarmasin who met the clinical criteria of suspected PE, assessed with clinical scorings (Well’s score for PE and Padua prediction score for venous thromboembolism), and receiving anticoagulant therapy recorded in medical records were included in this study. A total of 91 patients were included, with most patients were female (59.3%), average age of 53.36 years, average BMI of 25.82 kg/m2, having normal electrocardiogram (79.1%), with history of hypertension (56%), and no histories of smoking (94.5%), diabetes mellitus (70.3%), heart failure (93.4%), coronary artery disease (96.7%), and chronic lung disease (95.6%). As much as 39.57% patients with suspected PE was deceased during the course of hospitalization. Unadjusted analysis showed significant increased levels of PT, APTT, and CRP, in deceased patients compared to those discharged alive (mean 14.62 vs 11.91 seconds, 42.94 vs 28.57 seconds, and 98.19 vs 47.01 mg/dL, respectively; p value < 0.01), and a non-significant increased level of D-dimer (mean 10.89 mg/L; p = 0.09). Multivariate logistic regression showed non-significant associations between PT, APTT, D-dimer, and CRP with in-hospital mortality (p values of 0.06, 0.14, 0.52, and 0.23, respectively). In conclusion, there is no association between coagulation parameters, CRP, and D-dimer levels with in-hospital mortality in COVID-19 patients with suspected PE. A further study with a larger sample size is needed to see the role of laboratory findings in predicting in-hospital mortality in COVID-19 patients with suspected PE.

NEONATAL SCROTAL WALL NECROTIZING FASCITIS (FOURNIER GANGRENE SCROTUM) IN A ONE MONTH OLD NEONATAL: A RARE CASE REPORT

Objective: In this report, we present our case of a one-month-old neonatal with Fournier gangrene who was referred to our hospital. Case(s) Presentation: A one-month-old patient came from a referral hospital with chief complaint had a diaper rash since 6 days before hospital admission, fever existed, and patient’s scrotal became swollen and appear white spot. The patient was referred to Ulin General Hospital Banjarmasin for a necrotomy debridement. Discussion: We recommend more than one antibiotic to cover it, including one specifically targeted toward it. Both Enterococcus and S. aureus have been implicated as the causative organisms of Fournier gangrene in previous reports. Conclusion: Fournier gangrene in neonatal is a rare case and potentially life-threatening disease, it is a progressive gangrenous of the genitalia, perineum and perianal regions.
 Keyword: Fournier gangrene, scrotal, neonatal

Differences of Gonial Index value in male and female hypertension patients using panoramic radiography

Objectives: This study is aimed to measure the Gonial index (GI) value in male and female hypertensive patients using panoramic radiography. Materials and Methods: This is a comparative analytical research. The sampling technique used was the purposive sampling technique. The sample of this study was primary data from panoramic radiographs of hypertensive patients who had been X-rayed at the Radiology Installation of Ulin General Hospital, Banjarmasin. Results: There was no significant difference in the gonial index (GI) values between men (17.83 mm) and women (19.17 mm), with the size of the right region of the female 20.33 mm and the left of the female 16.67 mm and the size of the right region of the male is 17.03 mm and the left male is 19.97 mm. Conclusion: There was no significant difference between the gonial index (GI) values ​​between women and men, although the decrease of bone density in women is higher than in men.

The Risk of Adverse Drug-Drug Interactions for Stable Angina Pectoris Patients with Heart Failure Complication Prescribed Polypharmacy

Stable angina pectoris (SAP) is an imbalance that occurs when myocardial oxygen need increases disproportionally, causing complaints of chest pain. Uncontrolled SAP can lead to a complication of heart failure (HF). Polypharmacy treatment frequently given to SAP patients with HF complications can be potentially detrimental for them. This study aims to determine the risk of adverse drug-drug interactions in SAP patients with HF complications prescribed polypharmacy. This was an analytic observational study with a cross-sectional approach using retrospective data from medical record data from 2020-2021 among hospitalized patients in cardiology ward Ulin General Hospital, Banjarmasin. Potential drug-drug interactions were determined using the Lexicomp tool from the UpToDate® site. Prevalence Odds Ratio (POR) and 95% Confidence Interval (95%CI) were determined using the Logistic Regression test at the 95% level of confidence. Twenty-four SAP patients with HF were recruited. According to its potential interactions, the most interactions were under category C (82.6%), followed by category B (11.3%) and category D (6.0%). Based on its level of severity, the most common was moderate (77.4%), followed by minor (13.0%) and major (9.5%). SAP patients with HF who were not prescribed polypharmacy had a lower risk of adverse drug-drug interactions by 64.7% compared to polypharmacy users, although it was not statistically difference (crude POR 0.353, 95% CI; 0.360-3.421; p-value = 0.369). This study shows that there is a tendency of lower risk of adverse drug-drug interactions in SAP patients with HF complication prescribed polypharmacy compared to those without polypharmacy, but the association is not statistically significant.

Clinical epidemiology pattern of orthopedic trauma during the COVID-19 pandemic: A multicenter study (Dr. Hasan Sadikin General Hospital and Ulin General Hospital)

Link of Video Abstract: https://youtu.be/JRX2wJWFCKs Introduction: COVID-19 has had profound implications on global healthcare systems, and this pandemic management has led to a significant change in orthopedic surgical activity. We aimed to evaluate the types and incidence of fractures treated during the pandemic to provide insight into the situations for which orthopedic trauma surgeons should be prepared in unusual circumstances that may arise in the future. Methods: Descriptive observational cross-sectional study from Dr. Hasan Sadikin General Hospital and Ulin General Hospital was conducted from electronic medical records between January 2018 and December 2022. Analysis was performed using SPSS version 26 on descriptive analysis using mean, frequency, percentage, and standard deviation. Results: 2890 patients were enrolled for the current cohort, from 2018 until 2022, with predominantly male (n = 2117). Even though, an increase in overall admission from 2018 (n = 631) to 2019 (n = 784), a decrease after that occurred during the COVID-19 pandemic, which is from 2020, 2021, and 2022 (n = 652, 500, and 323, respectively) Conclusion: Knowing the number of fractures can be a tool to evaluate the types and incidence of fractures treated during the pandemic to provide insight into the situations for which orthopedic trauma surgeons should be prepared in unusual circumstances that may arise in the future.

Differences in Antegonial Index values in type II diabetes mellitus patients using panoramic radiography

Objectives: This research is aimed to analyze the value of the antegonial index in patients with type II diabetes mellitus using panoramic radiography.
 Materials and Methods: This research is using stratified random sampling study with unpaired numerical comparative formula. The research sample was patients who were visiting and diagnosed with type II diabetes mellitus for ≤ 5 years and > 5 years by doctors at the Internal Diseases Polyclinic at Ulin General Hospital, Banjarmasin. Mandibular cortical thickness can be seen in the results of panoramic radiographs using radiomorphometric measurements with mandibular cortical index measurements, which is called as antegonial index. Antegonial index measurement as a screening tool can detect either the patient is positive or negative for having bone resoption. 
 Results: The result showed average value of mandibular cortical thickness in patients with diabetes mellitus type II with a period of disease ≤ 5 years does not match the normal limit of > 3.2 mm, which is 2.57 ± 1.41 and the average value of mandibular cortical thickness in the group of patients with long period of disease > 5 years is 2.19 ± 0.76.
 Conclusion: Mandibular cortical thickness in patients with type II diabetes mellitus for ≤ 5 years and > 5 years is not within normal limits.

Characteristics of outpatient gynecology oncology services before and after COVID-19 pandemic at Ulin Regional General Hospital, Banjarmasin, Indonesia

HIGHLIGHTS The characteristics of gynecology oncology services at Ulin Regional General Hospital before and after the COVID-19 pandemic were evaluated. There was a decrease of 19% in the number of visits by Gynecology Oncology Clinic patients at Ulin Regional General Hospital between the period of March 2019 - February 2020 and March 2020 - February 2021. ABSTRACT Objective: The aim of this study was to investigate the characteristics of the Gynecology Oncology Outpatient Clinic at Ulin Hospital Banjarmasin before and after the COVID-19 pandemic. Materials and Methods: This descriptive study utilized existing patient data from the Gynecology Oncology Outpatient Clinic at Ulin Hospital Banjarmasin covering the period from March 2019 to February 2021. The study received ethical approval from the Ulin General Hospital ethics committee with clearance number 10/I-Reg Research/RSUDU/23. The collected data was presented in a tabular format to compare the service characteristics before the pandemic (March 2019 - February 2020) and after the pandemic (March 2020 – February 2021). Results: During the periods of March 2019 – February 2020 and March 2020 – February 2021, there was a reduction of 19% in patient visits. The number of patients undergoing treatment also decreased, from 1081 patients (53.9%) in the period of March 2019 – February 2020 to 926 patients (46.1%) in the period of March 2020 – February 2021. Notably, there was a decrease in the number of patients undergoing surgical procedures, dropping from 76 patients (70.4%) in the period of March 2019 – February 2020 to 32 patients (29.6%) in the period of March 2020 – February 2021. A similar trend was seen in patients receiving chemotherapy, with the count decreasing from 1005 patients (52.9%) in the period of March 2019 – February 2020 to 894 patients (47.1%) in the period of March 2020 – February 2021. These changes were attributed to various hospital measures implemented to address the COVID-19 pandemic, including a reduction in outpatient clinic visits and the temporary suspension of surgical procedures from March 2020 to October 2020 to minimize potential exposure. Conclusion: The study highlights a noticeable decline in both the frequency of visits to the Gynecology Oncology Outpatient Clinic at Ulin Regional General Hospital Banjarmasin and the number of patients receiving treatment during the periods before and after the onset of the COVID-19 pandemic.

Correlation between Total Lymphocyte Count, C Reactive Protein, and Neutrophil Lymphocyte Ratio Levels with Gastrointestinal Manifestations in Covid-19 Patients Treated at Ulin Hospital, Banjarmasin

BACKGROUND: Coronavirus disease can affect the digestive system and cause gastrointestinal manifestations. The increase in C-reactive protein (CRP) correlates with the severity of the disease. The neutrophil-to-lymphocyte ratio (NLR) is a useful prognostic factor in the early screening of patients with COVID-19. A low lymphocyte count can also predict gastrointestinal involvement. AIM: This study aims to determine the correlation between TLC, CRP, and NLR levels on gastrointestinal manifestations in COVID-19 patients treated at Ulin General Hospital, Banjarmasin. METHODS: This study used a cross-sectional design. Data were taken consecutively using the medical records of confirmed COVID-19 patients with gastrointestinal manifestations. The number of subjects in this study was 88 patients. RESULTS: A decrease in TLC levels (<1740 g/dL) was not proven to have a significant correlation with gastrointestinal manifestations in COVID-19 patients (p = 0.176). Increased levels of CRP (>48 mg/L) had a significant correlation by 5.71 times compared to subjects who did not experience increased CRP (p < 0.00001). Increased levels of the NLR (>6 mg/L) had a significant correlation by 2.82 times compared to subjects who did not experience an increase in NLR (p = 0.032). CONCLISION: An increase in CRP levels >48 mg/L and levels of NLR >6, respectively, allowed the subject to experience gastrointestinal symptoms by 5.71 times and 2.82 times when infected with COVID-19, while a decrease in total lymphocyte count <1740 was not proven to have a significant correlation with gastrointestinal manifestations.

Blood cord’s zinc serum level is associated with general health status and outcomes: A suggestion of cut-off novelty in newborns

Purpose: This study aims to analyze the associations of zinc serum levels in the blood cord with the general health status of neonates, along with the characteristics and outcomes in Ulin General Hospital, Banjarmasin. Design/Methodology/Approach: A cross-sectional study was conducted in October-November 2021. The subjects were divided into two groups based on the zinc serum level (≤67.5 µg/dl and >67.5 µg/dl). The cut-off was determined by the receiver operating characteristic (ROC). Findings: There were 35 subjects in the group with zinc serum level ≤67.5 µg/dl and 34 subjects in the group with zinc serum level >67.5 µg/dl. Neonates with zinc serum level over the cut-off significantly had a higher birth weight (p=0.038), lower incidence of prematurity (p=0. 02, OR 0.21; 95%CI: (0.05-0.84)), lower incidence of anemia (p=0.001, 95%CI: 0.1(0.012-.89)), neonatal jaundice (p=0.02, OR 0.3; 95%CI: 0.1-0.85), and neonatal infections (p=0.000 OR 0.008; 95%CI: 0.001-0.067). Conclusion: The zinc serum level of the blood cord is strongly associated with the general health status and outcomes of the newborn. It is also associated with the general health of neonates, birth weight, prematurity, the incidence of infection, jaundice, anemia of newborns, and the need for NICU during the treatment. Limitations: A relatively short period of observation and a small number of subjects due to the limitation of resources. Practical Implications: propose the importance of zinc intake in pregnancy as it strongly implicates the general health status and outcomes of neonates. Contribution to Literature: This study provides a cut-off value with significant results and encourages further investigation to determine the need and effects of early zinc supplementation.

Overview of Children with Covid-19 Confirmation Case in Ulin General Hospital, Banjarmasin, South Kalimantan 15 March - 15 July 2020

Coronavirus disease (COVID-19) is still a health problem in Indonesia, where the number of cases reported on 10 July 2020 was 72,347, with 3,469 deaths. Banjarmasin City is the 6th highest COVID-19 case after West Java Province. This study aims to describe the case of COVID-19 in pediatric patients treated at Ulin General Hospital, Banjarmasin, South Kalimantan. Method: This study was an observational descriptive study. The data source in this study is the primary data of patients hospitalized from March to July 2020 at Ulin Hospital Banjarmasin. Most COVID-19 occurred in the age group 11-18 years. Most cases of COVID-19 occurred in men (61.11%). 4 patients died. Most comorbidities are kidney failure, malignancy, and hematological disorders. There were 10 patients (55.56%) with clinical and investigative pneumonia examinations. Significant supporting laboratory testing results are an increase in LDH and D-Dimers. Ulin City Hospital, Banjarmasin, South Kalimantan, is a referral hospital with a total number of COVID-19 patients treated by 18 people. Need further research and an increase in inpatient cases at Ulin City Hospital Banjarmasin.

Pathological Characteristics of Fiberoptic Bronchoscopy Procedure in Ulin General Hospital, Banjarmasin

Introduction: Fiberoptic Bronchoscopy (FOB) has emerged into the method of choice for the detection of lung tumors due to its availability of Adequate cytological and histological samples in the form of broncho-alveolar lavage, bronchial brushings, and bronchial forceps biopsy. This study aims to identify characteristics of bronchoalveolar lavage, aspiration cytology, brushing cytology and forceps cytology of patients suspected with malignancy at the Ulin Regional Hospital in South Kalimantan. Methods: A cross-sectional study was carried out utilizing medical documentation of patients suspested lung cancer from March 2018 to March 2020. Data were grouped by gender, age, type of procedure, and cytology and histopathology findings. Results: The result showed that 67.5% of 117 patients who underwent bronchoscopy had positive results and common histological diagnosis The frequent histopathological conclusion was adenocarcinoma (45.6%) tailed by squamous cell carcinoma (40.55). Forceps bronchoscopy showed a greater positivity rate (75.0%) than bronchoscopy without forceps (63.6%), we also found that by combining BAL and brushing and forceps biopsy, the detection rate of lung malignancy increased to 85.7%, but no correlation between the type of procedure and the likelihood of malignancy was discovered. Conclusions: Forceps bronchoscopy showed a greater positivity rate than bronchoscopy without forceps, but no correlation between the type of procedure and the likelihood of malignancy was discovered in our study.

Clinical Characteristic of Different SARS-CoV-2 Variants in South Kalimantan, Indonesia: A Case Study

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has undergone various mutations of Corona Virus Disease 2019 (COVID-19). The World Health Organization (WHO) has designated B.1.617.2 (Delta) and B.1.1.529 (Omicron) as variants of concern (VOC). Since clinical features and epidemiological characteristics of patients infected with SARS-CoV-2 variants remain largely unknown, especially in Indonesia, this study aimed to identify the clinical characteristics of COVID-19 patients from South Kalimantan, Indonesia.Methods: Data from medical records of COVID-19 patients at Ulin General Hospital Banjarmasin from June 2021 to February 2022 were randomly extracted, containing demographic data, comorbidities, and laboratory data, as well as the type of virus. Results: In total, 32 patients were included, 9 were infected with delta, 14 with probable omicrons, and 9 with non-VOC. Patients in the probable Omicron group were significantly older than other groups (median age 64 years old, range 54–73 years; p=0.049), had hypertension as the dominant comorbidity (85.7%; p=0.039), the onset appeared slightly earlier (median 3 days; range 2-3 days, p=0.062), with no anosmia symptom (p=0.006). Critical illness predominated and mostly survived in all variants but was not statistically significant (p=0.590 and 0.726, respectively). The three variants showed similarities in laboratory findings; hence, statistical analysis suggested that the leucocytes differed significantly (p=0.020).Conclusions: Patients with the likely Omicron variant are much older, have hypertension as their main comorbidity, do not have any symptoms of anosmia, and have higher leukocyte counts compared to other variants.

Comparing serum ferritin levels during COVID-19 infection and recovery period in pediatric patients with transfusion-dependent thalassemia, a single-center study.

Ferritin has been recognized as a predictor of severity among Coronavirus-19 disease (COVID-19) patients. Studies have shown higher levels of ferritin in patients with COVID-19 than in healthy children. Patients with transfusion-dependent thalassemia (TDT) basically have high ferritin level due to iron overload. It is uncertain whether serum ferritin level in these patients is associated with COVID-19 infection. To evaluate ferritin levels in TDT with COVID-19 before, during, and after the course of infection. This retrospective study enrolled all TDT children with COVID-19 infection that were hospitalized in Ulin General Hospital Banjarmasin during the COVID-19 pandemic (March 2020 to June 2022). Data were collected from medical records. There were 14 patients included in this study, 5 patients had mild symptoms and 9 patients were asymptomatic. The mean of hemoglobin level upon admission was 8.1 ± 3 g/dL and serum ferritin level were 5148.5 ± 2651.8 ng/mL. The average serum ferritin level during COVID-19 infection was 2373.2 ng/mL higher than before infection and then decreased by 952.4 ng/mL after infection. We found no association of increasing serum ferritin with patients' symptoms (p = 0.27). The severity of anemia also was not correlated with the presentation of COVID-19 infection (p = 0.902). Serum ferritin levels in TDT children may not reflect disease severity or predict poor outcomes during COVID-19 infection. However, the presence of other co-morbid conditions/confounders warrants cautious interpretation.

HUBUNGAN INFILTRASI LIMFOSIT PADA PROSTAT DENGAN RETENSI URINE PADA BENIGN PROSTATIC HYPERPLASIA DI RSUD ULIN BANJARMASIN

Benign prostatic hyperplasia (BPH) is a common condition in elderly men. BPH may cause lower urinary tract symptoms (LUTS) and urinary retention. Chronic inflammation is a common founding in histological examination of BPH and related to a higher risk of urinary retention. The purpose of this study is to analyze the association between lymphocyte infiltration in prostate and urinary retention in BPH in Ulin General Hospital Banjarmasin. This is an analytic observational study with cross sectional approach. There are 78 samples, collected by purposive sampling method. There are 47 (60,26%) patients diagnosed with urinary retention, while 31 (39,74%) others are diagnosed with LUTS. Lymphocyte infiltration is found in 68 (87,18%) specimens, consist of 20 (25,64%) specimens of BPH with mild inflammation, 34 (43,59%) specimens of BPH with moderate inflammation, and 14 (17,95%) specimens of BPH with severe inflammation. There is no lymphocyte infiltration found in 10 (12,82%) specimens. The result of the analysis is P = 0,320. The conclusion of this study is that there is no significant association between lymphocyte infiltration in prostate and urinary retention in BPH in Ulin General Hospital Banjarmasin

BMI and TLC increase Neoadjuvant Chemotherapy Response in Patients with Locally Advanced Breast Cancer

Anthracycline-based neoadjuvant chemotherapy is the recommended therapy for locally advanced breast cancer (LABC) patients. Unfortunately, no study has reported the relationship between body mass index (BMI), total lymphocyte count (TLC), and responses to this type of chemotherapy. This study aimed to determine the relationship between BMI, TLC, and response to doxorubicin/epirubicin neoadjuvant chemotherapy in LABC patients. A retrospective cohort design was applied to medical records of LABC patients undergoing neoadjuvant chemotherapy at Ulin General Hospital Banjarmasin, Indonesia, from July to December 2021. BMI and TLC data were assessed based on the values before chemotherapy, while the chemotherapy response was measured using the RECIST 1.1 criteria after 3 cycles. Multinomial logistic regression test with 95% confidence level was used to analyze these data. The results showed that as many as 71% of patients experienced a Partial Response (PR), while 5% and 23% of the patients demonstrated Stable Disease (SD) and Progressive Disease (PD), respectively. Each increase in BMI of 1 kg/m2 was significantly associated with an increase in the occurrence of PR and PD by 1.26 times and 1.29 times, respectively, when compared to the occurrence of PD. Meanwhile, an increase in TLC of 100 cells/mm3 was associated with an increase in the occurrence of PR by 6.83 times and an increase in the occurrence of SD. of 6.94 when compared to the occurrence of PD. Therefore, there is a significant relationship between BMI, TLC, and response to anthracycline-based neoadjuvant chemotherapy in LABC patients

Babies born to obese mothers: what are the characteristics and outcomes?

<div align="justify"><p>Obesity during pregnancy puts the mothers at risk of significant medical conditions and is also associated with some medical problems in neonates. This study aimed to analyze the characteristics and outcomes of babies born to obese mothers at a tertiary hospital in Banjarmasin, Ulin General Hospital. This study was observational using secondary data of neonates born at Ulin General Hospital, Banjarmasin, on January 2020-October 2021. The total number of subjects included in this study was 110, divided into two groups based on the obesity status of the mother (obese and non-obese). Common maternal characteristics of the obese mothers were having higher education (43.6%), being a housewife (67.3%), being diagnosed with severe preeclampsia (58.2%), and having infection risk (54.5%). Of the babies, 100% were delivered by C-section, 21.8% were premature, 12.7% had excessive birth weight, and 54.5% were requiring treatment before being discharged. For the outcomes, the average length of stay was 4.5±3.6 days (p<0.05) and the need for NICU admission was 20% (p>0.05). The most compelling characteristics and outcomes of babies born to obese mothers in this study were delivered by C-section, had excessive birth weight, unwell babies, and had a longer hospital stay.</p></div>

Characteristics of Babies Born to HIV Positive Mothers in Ulin General Hospital Banjarmasin January – December 2020

The high incidence rate of mothers with Human Immunodeficiency Virus (HIV) increases the potential of vertical transmission to the baby. HIV is a group of retroviruses that attacks the immune system. It can be transmitted through the exchange of various body fluids from the infected person, such as blood, breast milk, semen, and vaginal fluids. HIV can also be passed from a mother to her child during pregnancy and childbirth. Transmission of HIV from mother to baby is called a vertical transmission and may occur in 3 ways, including antenatal, perinatal, and postnatal (breast milk). This study aims to describe the characteristics of babies born to HIV positive mothers at Ulin General Hospital, Banjarmasin during January-December 2020. This is a descriptive observational study using secondary data from medical records of the babies born to HIV mothers at Ulin General Hospital, Banjarmasin. We include 13 cases of babies born to HIV-positive mothers. The characteristics of the babies were male (53.8%), born without asphyxia (92%), has normal birth weight (84.6%), full-term (92%), and 84.6% of babies were delivered through C-section. The results showed that it is necessary to work together with various fields to get early intervention for each baby.

Prognostic Value of the Systemic Immune-Inflammation Index in EGFR Mutation-Positive Lung Adenocarcinoma Patients Treated with Tyrosine Kinase Inhibitors

Introduction: Inflammation is considered a promoting factor in tumorigenesis and progression. Inflammatory parameters calculated from complete blood counts such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) are related to poor prognosis in lung cancer patients. However, few studies have reported on lung cancer with targeted therapy. This study aimed to explore a correlation between NLR, PLR, and SII to survival rates in advanced lung adenocarcinoma epidermal growth factor receptor (EGFR) mutation-positive with tyrosine kinase inhibitors (TKIs) as the main choice of treatment. Methods: A retrospective observational study obtained 50 medical record data from patients with EGFR mutation-positive lung adenocarcinoma treated by TKIs at Ulin General Hospital Banjarmasin from January 2017 to December 2019. The optimal cut-off values for NLR, PLR, and SII were obtained using the receiver operating characteristic curve (ROC). Kaplan–Meier analyses were used to assess the prognostic value of inflammation parameters in overall survival (OS) and progression-free survival (PFS). Results: The optimal cut-off value for NLR, PLR, and SII was 6.095, 356.935, and 1767.0, respectively. However, only the SII was significantly associated with survival; SII ≥ 1767.0 correlated with shorter OS (18 months vs. 28 months, p = 0.014) and PFS (7 months vs. 12 months, p = 0.004). Conclusion: Pre-treatment SII can be a prognostic factor for survival in EGFR mutation-positive lung adenocarcinoma patients receiving TKIs.