The article identifies prospects for trade and economic cooperation between Ukraine and the Middle East. It is shown that in the second quarter of the XXI century, the tendency to deepen international cooperation in order to effectively use a country's export and production potential is emerging. It is determined that the state's trade policy is primarily a manifestation of political and economic instruments of its foreign economic relations, so Ukraine should actively enter into liberalization of bilateral and multilateral agreements, including with the Middle East. It is substantiated that the formation of effective relations with that region's countries takes place in a competitive environment, as about half of the exports of the Middle East are to developed countries in Europe and Asia. The dynamics of the main indicators of foreign trade and the geographical structure of Ukraine's exports on average in the 2016–2020 period are analyzed. The tendencies of dynamics of volumes and structure of export / import of Ukraine to the countries of the Middle East for this period are assessed. It is concluded that in the medium term, trade liberalization has significant potential to increase Egyptian and Turkish imports to Ukraine, as well as Ukrainian exports to Egypt, Turkey and the United Arab Emirates. The necessity to emphasize the substantiation of the program of long-term economic and scientific-technical cooperation is shown. It is also necessary to study the possibilities of free trade zones, preferential regimes of industrial zones, intermediary opportunities and potential of some influential Arab countries to promote and consolidate in other markets, as well as promising forms of promoting most traditional Ukrainian goods in the Middle East.