In the fifth year since human cloning to generate stem cells was legalised in the UK, what progress has been made towards taking stem-cell therapy from laboratory to clinical practice? In 2000, articulating robust UK Government support, then Health Minister Yvette Cooper proclaimed that stem cells from cloned human embryos “could prove the Holy Grail in finding treatments for cancer, Parkinson's disease, diabetes, osteoporosis, spinal cord injuries, Alzheimer's disease, leukaemia and multiple sclerosis … transform[ing] the lives of hundreds of thousands of people”. 1 Kite M Disabled MPs plead for stem cell research. Times (Lond). Dec 16, 2000; Google Scholar But 4 years later, the technical difficulties and biological hazards inherent in cloning human embryos and developing treatments from their stem cells led Richard Gardner, Chairman of the Royal Society Working Group on Stem Cells and Therapeutic Cloning, to doubt whether this would ever be “a procedure that becomes widely available … There are concerns about the efficiency and elaborateness of the procedure, and it's going to be very time-consuming and very expensive”. 2 Sample I Is there hope behind the stem cell hype?. Guardian. Aug 19, 2004; Google Scholar So, to paraphrase May 25th's Saving Faces event in London, UK, are stem-cell therapies hype, or hope, or substance? Collaboration in cardiovascular stem-cell researchAlthough the excitement of discovery motivates medical researchers, competition among them is a driving force and is considered normal and healthy. Articles that are first in the field can have precedence for publication in journals with high impact factors. Academic promotion is aided by such articles and the UK Research Assessment Exercise (RAE) demands them. Funding bodies distribute resources to the authors of such articles. For gene therapy, the motive of personal recognition by academics striving to be the authors of articles describing small advances in basic science or small clinical studies led to the publication of fragmented information that did not advance the research field. Full-Text PDF Semantics and ethics of human embryonic stem-cell researchThe ethical debate about human embryonic stem-cell research has revisited the old embryo-research debate, which UK law put within a framework as long ago as 1990,1 licensing it under strict conditions, permitting only research linked to reproduction, and creation of embryos for research when “necessary”. In the aftermath of animal research on stem cells, new categories were added to the statute,2 allowing also “research for serious disease” on the human embryo. Although on both occasions the legal process had been democratic3 and expressed its respect for the symbolic nature of the embryo,4 a judge5 was asked to determine whether an embryo created by somatic-cell nuclear transfer was an embryo under the Human Fertilisation and Embryology Act, a matter settled on appeal in February, 2002. Full-Text PDF