The accurate estimation of the tyre-road peak friction coefficient is the key basis for the normal operation of the vehicle active safety control system. The estimation algorithm needs to be able to adapt to various conditions encountered in the actual driving process of the vehicle and obtain the estimation results timely and accurately. Therefore, a new normalized strategy is proposed in this paper. The core is the equal ratio between the peak friction coefficient and the utilization friction coefficient between adjacent typical roads. This strategy can establish the direct connection (normalization) between tyre force and tyre-road peak friction coefficient through most tyre models in the field of vehicle dynamics and accomplish estimation by combining with the filtering algorithm. In addition, most of the vehicle dynamic estimation algorithms are limited by road excitation, and it is difficult to obtain satisfactory estimation results. This strategy can greatly reduce the system error caused by insufficient road excitation (slip rate is not 0.15–0.20) and improve the applicability of the estimation algorithm to the actual driving process of the vehicle. Finally, the magic formula (MF) tyre model is selected to describe the tyre characteristics after treatment of the normalized strategy; the tyre-road peak friction coefficient is estimated by combining the extended Kalman filter and vehicle dynamics model. Satisfactory estimation results are obtained in both simulation and real vehicle tests, which verifies the effectiveness of the proposed normalized strategy.