As a widely used device in the field of air cooling and heat dissipation of electronic equipment, ventilation walls often have the problem of whistling caused by airflow. This paper presents a numerical study on the flow-induced whistling noise of a ventilation wall. Firstly, the interior flow field of the ventilation wall under typical working conditions was calculated. Secondly, the structure wet mode of the ventilation wall was calculated considering the airflow influence on the structural vibration. Thirdly, taking the fluid pressure fluctuation at the surfaces of the ventilation wall as excitation source, the structural vibration and radiation noise of ventilation wall was simulated, respectively. Finally, the structure of the ventilation wall was optimized to reduce the whistling noise. The results show that the high velocity airflow causes strong fluid-structure coupling of the ventilation wall. Besides, the peak frequency band of whistling noise ranges from 112Hz to 125Hz, and the maximum sound pressure level (SPL) reaches 87.3dB. Moreover, by improving the structure of ventilation wall, the maximum SPL of whistling noise deceases about 10.5dB, which significantly reduces the flow-induced noise. In conclusion, this paper could provide a method for reducing the flow-induced noise of ventilation walls.