Typical Wind Research Articles

Natural Polymer-Based Hydrogel Dressings for Wound Healing.

Significance: Acute wounds such as severe burns and chronic wounds like diabetic ulcers present a significant threat to human health. Wound dressings made from natural polymers offer inherent properties that effectively enhance wound healing outcomes and reduce healing time. Recent Advances: Numerous innovative hydrogels are being developed and translated to the clinic to successfully treat various wound types. This underscores the substantial potential of hydrogels in the future wound care market. Economically, annual sales of wound care products are projected to reach $15-22 billion by 2024. Critical Issues: While chitosan-, cellulose-, and collagen-based hydrogel dressings are currently commercially available, scaling-up and manufacturing hydrogels for commercial products remain a challenging process. In addition, ensuring the sterility and stability of the chemical or biological components comprising the hydrogel is a critical consideration. Future Directions: In light of the persistent increase in wound fatalities and the resulting economic and social impacts, as well as the importance of educating the public about dietary health and disease, there should be increased investment in new wound care dressings, particularly hydrogels derived from natural products. With numerous researchers dedicated to advancing preclinical hydrogels, the future holds promise for more innovative and more personalized hydrogel wound dressings.

Biohybrids for Combined Therapies of Skin Wounds: Agglomerates of Mesenchymal Stem Cells with Gelatin Hydrogel Beads Delivering Phages and Basic Fibroblast Growth Factor.

There is great interest in developing effective therapies for the treatment of skin wounds accompanied by deep tissue losses and severe infections. We have attempted to prepare biohybrids formed of agglomerates of mesenchymal stem cells (MSCs) with gelatin hydrogel beads (GEL beads) delivering bacteriophages (phages) as antibacterial agents and/or basic fibroblast growth factor (bFGF) for faster and better healing, providing combined therapies for these types of skin wounds. The gelatin beads were produced through a two-step process using basic and/or acidic gelatins with different isoelectric points. Escherichia coli (E. coli) and its specific T4 phages were propagated. Phages and/or bFGF were loaded within the GELs and their release rates and modes were obtained. The phage release from the basic GEL beads was quite fast; in contrast, the bFGF release from the acidic GEL beads was sustained, as anticipated. MSCs were isolated from mouse adipose tissues and 2D-cultured. Agglomerates of these MSCs with GEL beads were formed and maturated in 3D cultures, and their time-dependent changes were followed. In these 3D culture experiments, it was observed that the agglomerates with GEL beads were very healthy and the MSCs formed tissue-like structures in 7 days, while the MSC agglomerates were not healthy and shrunk considerably as a result of cell death.

Geospatial analysis of scour development post-protection in offshore wind farm

Scour is one of the most serious challenges affecting the normal operation of offshore wind power. Whether scour protection measures are effective directly affects the safety and economical efficiency of an offshore wind farm. Data mining techniques and analytical tools based on monitoring data analysis plays a critical role in making appropriate strategic decisions. Post-protection scour inspection was continuously carried out on a typical offshore wind farm composed of 72 turbines installed with monopile foundations for three times over the course of two years. The geospatial properties of scour, including maximum scour depth, maximum scour extension, and scouring and siltation volume, were analyzed in detail. The possible autocorrelation of scour data measured for each turbine was identified using data-driven decision-making process. The results indicate that the characteristics of the investigated scour and their spatial dependence on the turbines of the inspected offshore wind farm generally show an upward trend over time. A High-High area in the local geospatial dependency map of maximum scour depth was identified, and an equation was drawn for predicting development of maximum scour depth. These findings show indications to reduce the operation and maintenance costs of offshore wind farms and improve the efficiency for upgrading scour protection on specific offshore wind foundations.

Wind speed multi-step prediction based on the comparison of wind characteristics and error correction: Focusing on periodic thermally-developed winds

To leverage the abundant wind energy resources available in mountainous regions, an increasing number of wind power facilities and associated transportation infrastructure are being constructed in these areas. There are different types of intense winds in mountainous areas and the non-linear characteristics of the different intense winds vary significantly. The periodic thermally-developed winds are the commonly occurring type of intense wind. Based on the comparison of wind characteristics, this research proposes a prediction model for the periodic thermally-developed winds. The research utilizes the Bi-directional Long Short-Term Memory model(Bi-LSTM), which has been optimized by the Bayesian optimization(BO), to predict wind speed. Based on the relationship between wind field characteristics in periodic thermally-developed winds, a regression correction module is proposed using a joint probability model. Additionally, to address the volatility and uncertainty of wind speed, a Gaussian mixture model is employed for probability prediction. The experimental results demonstrate several findings: 1. The BO-Bi-LSTM model accurately and reliably predicts multi-step results for periodic thermally-developed winds in mountainous areas. 2. The proposed correction module, when combined with other models, yields improved wind speed accuracy compared to the uncorrected values. 3. The Gaussian mixture model produces probabilistic prediction results that consider both interval coverage and interval bandwidth simultaneously. 4. The proposed model can successfully predict periodic thermally-developed winds in mountainous areas for practical engineering purposes, resulting in reliable probabilistic prediction outcomes. It is of great significance for the utilization of wind energy resources and the driving safety of vehicles on ancillary structures.

Counting the Cost of Cellular and/or Tissue-Based Products in Diabetic Foot Ulcers: Is There a Justifiable Price Limit per Square Centimeter?

Objective: To identify how cellular and/or tissue-based products (CTPs) relate to value in terms of cost per quality-adjusted life years (QALYs) in wound care in comparison with treatments in other medical fields. Approach: This is a cross-sectional study and a cost-effectiveness analysis. Payment limits for each CTP were obtained via the Healthcare Common Procedure Coding System Q codes and formulated as cost inputs into a cost-utility model published for treatment of Wagner 1 diabetic foot ulcers using dehydrated human amnion and chorion allograft versus standard of care (SOC). Additional changes to cap the number of CTP applications and adjustments for recent inflation were made. The literature was searched for other cost-utility models in other diabetes-related diseases as a comparison. Results: When the payment limit was ≤$140 per square centimeter, interventions were dominant (less costly, better outcomes) compared with SOC. When the limit exceeded $430 per square centimeter, the cost-effectiveness threshold of $100,000/QALY was exceeded. Newer Q codes are generally much more expensive and likely to not be cost-effective, similar to the results for many other chronic diabetes-related diseases . Innovation: This study presents decision makers with tools, by which they can determine as to whether a given CTP is likely to be cost-effective for patients. Conclusion: Over a third of all CTPs will very likely result in noncost-effective interventions. This number is likely to be higher when wounds are larger or used in other wound types where they are less efficacious. The recent trend in much higher costs for CTPs is worrisome.

Exploring the Efficacy of Selected Allografts in Chronic Wound Healing: Evidence from Murine Models and Clinical Data for a Proposed Treatment Algorithm.

Significance: Chronic wounds can lead to poor outcomes for patients, with risks, including amputation and death. In the United States, chronic wounds affect 2.5% of the population and cost up to $28 billion per year in primary health care costs. Recent Advances: Allograft tissues (dermal, amnion, and amnion/chorion) have shown efficacy in improving healing of chronic, recalcitrant wounds in human patients, as evidenced by multiple clinical trials. Their mechanisms of actions have been relatively understudied, until recently. Research in murine models has shown that dermal allografts promote reepithelialization, amnion allografts promote granulation tissue formation and angiogenesis, and amnion/chorion allografts support all stages of wound healing. These findings confirm their effectiveness and illuminate their therapeutic mechanisms. Critical Issues: Despite the promise of allografts in chronic wound care, a gap exists in understanding which allografts are most effective during each wound healing stage. The variable efficacy among each type of allograft suggests a mechanistic approach toward a proposed clinical treatment algorithm, based on wound characteristics and patient's needs, may be beneficial. Future Directions: Recent advances in allografts provide a framework for further investigations into patient-specific allograft selection. This requires additional research to identify which allografts support the best outcomes during each stage of wound healing and in which wound types. Longitudinal human studies investigating the long-term impacts of allografts, particularly in the remodeling phase, are also essential to developing a deeper understanding of their role in sustained wound repair and recovery.

Comparative Effectiveness of Negative Pressure Wound Therapy with and Without Oxidized Regenerated Cellulose/Collagen/Silver-ORC Dressing.

Objective: Negative pressure wound therapy (NPWT) and oxidized regenerated cellulose (ORC)/collagen/silver-ORC (OCSO) dressings have individually demonstrated effectiveness in supporting wound healing, but few studies have examined their combined use. This retrospective data analysis compared wound outcomes following outpatient NPWT with and without OCSO dressings. Approach: A search of deidentified records from the U.S. Wound Registry resulted in 485 cases of wounds managed with NPWT with OCSO dressings. A matched cohort of patients who received NPWT without any collagen dressing (n = 485) was created using propensity scoring. For patients in the NPWT + OCSO group, OCSO was applied topically on or after the day of NPWT initiation and stopped on or before the day of NPWT termination. Results: Wounds managed with NPWT + OCSO were significantly more likely to improve and/or heal compared with wounds that received NPWT alone (p = 0.00029). The relative wound area reduction was 40% for patients receiving NPWT + OCSO, compared with 9% for patients receiving only NPWT (p = 0.0099). The median time to achieve 75-100% granulation coverage with no measurable wound depth was shorter by 8 days with NPWT + OCSO in all wound types (p = 0.00034), and by 14 days in surgical wounds (p = 0.0010), than with NPWT alone. Innovation: This is the first study examining the clinical outcomes associated with the integration of NPWT and OCSO dressings compared with the use of NPWT alone. These data support the novel practice of applying NPWT concurrently with OCSO dressings. Conclusion: This retrospective comparative analysis using real-world data demonstrated improved healing outcomes with integrated use of NPWT with OCSO dressings versus NPWT alone.

Spatially-Resolved Freestream Velocity Measurements At The NASA Langley 31-Inch Mach 10 Air Tunnel Using FLEET

Freestream velocity measurements in the NASA Langley 31-inch Mach 10 wind tunnel are reported in this paper using Femtosecond Laser Electronic Excitation Tagging (FLEET). The freestream measurements acquired during the January 2023 test campaign were the first direct measurement of freestream velocity in this hypersonic wind tunnel facility. Spatial distributions of time-averaged and instantaneous velocity measurements were obtained at all three typical wind tunnel freestream unit Reynolds number conditions of Re∞ /L = 1800000 [1/m] , 3600000 [1/m], and 6400000 [1/m], though the current paper focuses on centerline measurements for the three Re∞ /L and spatial distributions for one Re∞ /L. Measured values for time-averaged velocity and mean of the instantaneous velocity at the wind tunnel centerline agree within 5 m/s or 0.4% of the calculated velocity from the facility data acquisition system. Measurements acquired at locations away from the wind tunnel centerline reveal the spatial extent of the core flow of the hypersonic facility.

The Evolution of Commercial Negative Pressure Wound Therapy Systems over the Past Three Decades.

Significance: Since the introduction of the first commercial negative pressure wound therapy (NPWT) system nearly three decades ago, several key technological innovations have led to the wide adoption of the therapy. This is a review of the history and innovation of commercial NPWT systems for adjunctive management of open wounds. Recent Advances: Technical modifications have broadened NPWT options to include innovative dressing interfaces, tubing configurations, power sources, capability of topical wound solution instillation or irrigation, canister versus canister-free configurations, smart technology, and disposable versus larger reusable therapy units. While these options complicate product selection, they have greatly expanded the potential to manage a wide variety of wounds in patients who previously may not have been candidates for NPWT. Critical Issues: Basic yet mandatory requirements of NPWT include delivering an accurate level of negative pressure to the wound bed, maintaining a seal, removing wound surface exudate through the dressing interface, and patient adherence to prescribed therapy. Meeting these requirements is challenging in the face of variable wound types, wound locations, exudate levels, and exudate viscosity. While there are a growing number of marketed NPWT systems, each may have different characteristics and performance. Evaluating the functionality of each system and relevant accessories is complicated, especially as additional manufacturers enter the market. Understanding the key innovations and specific challenges they are intended to solve may aid health care providers in selecting appropriate NPWT technologies for patients. Future Directions: Evolving technology, including artificial intelligence, will likely play a major role in redefining NPWT safety, simplicity, and reliability.

A Retrospective Exploration of Pre-operative Antibiotic Prophylaxis with Cefazolin in Cesarean Sections: Implications for Obstetrics and Gynecologic Surgery.

Background: Post-partum infection is a major contributor to maternal mortality and is responsible for approximately 10% of maternal fatalities worldwide. The risk of infection is substantially higher in cesarean section procedures. Approximately 8% of women who undergo cesarean sections are susceptible to infection. Although the body of evidence supporting the regular pre-operative utilization of prophylactic antibiotic treatment is steadily expanding, its usefulness in cesarean sections has not yet been standardized, and post-partum infection is still a serious medical challenge. We aimed to retrospectively assess the prophylactic effectiveness of cefazolin in combination with other antibiotic agents in cesarean sections. Materials and Methods: Both uni-variable and multi-variable analyses were conducted to identify factors that may affect cefazolin pre-operative antibiotic prophylaxis in elective cesarean section operations. The uni-variable analysis included timing of administration, operation duration, body mass index (BMI), and wound type. A multi-variable logistic regression model was then created to determine which variables provide independent information in the context of other variables. Results: Time of administration did not affect prophylactic cefazolin efficacy. However, prophylactic cefazolin was 1.43 and 1.77 times more effective when the operation lasted for 45 minutes or more, compared with operations that were shorter than 45 minutes. Patients with a BMI ranging from 18 to 29 kg/m2 showed increased efficacy of prophylactic cefazolin compared with obese patients with a BMI exceeding 30 kg/m2. The effectiveness of prophylactic cefazolin decreased by 95% in patients with clean-contaminated surgical incisions compared with those with clean surgical incisions. Conclusions: Our findings demonstrate that administering pre-operative prophylactic antibiotic agents to women undergoing cesarean section resulted in a reduction in post-partum infections, thereby reducing maternal mortality. Furthermore, optimal timing of administration, re-dosing if necessary, length of prophylactic medication, and dosing adjustments for obese patients are crucial factors in preventing surgical site infections and promoting antimicrobial stewardship.

Wellbeing, quality of life and satisfaction of patients with hard-to-heal wounds: a descriptive study.

A hard-to-heal wound is defined as a wound that failed to proceed through the normal phases of wound healing in an orderly and timely manner. The purpose of this article is to describe the impact of hard-to-heal wounds on the wellbeing, quality of life (QoL) and satisfaction with QoL of patients in Oman with hard-to-heal wounds. A descriptive cross-sectional study of patients with hard-to-heal wounds attending three tertiary care hospitals using a self-reported questionnaire was conducted. A total of 275 patients took part in the study. Patients reported a low wellbeing score (67.06±19.72), moderate QoL score (52.18±25.07) and moderate satisfaction scores (68.91±23.88). Significant mean differences were reported with age, sex, educational level, monthly income and type of wound all at p<0.05. The findings of this study demonstrated that hard-to-heal wounds could influence the wellbeing, QoL and overall satisfaction with QoL of patients. Funding was received through an internal grant of the Sultan Qaboos University to conduct the research conducting the research (IG/CON/FACN/20/01). The authors have no conflicts of interest to declare.

Maggot therapy for resistant infections: the disconnect between scientific evidence, clinical acceptance and practice.

Practitioners and scientists are re-examining marginalised wound care therapies to find strategies that combat the growing problem of antimicrobial resistance (AMR) without compromising patient outcomes. Maggot therapy (MT) makes up just an estimated 0.02% of UK's National Health Service spending on wound care. This study aims to uncover why MT is not used more often, despite its affordability and high level of efficacy for both debridement and disinfection, particularly in the context of AMR infections, and to determine what can be done to ensure MT is more effectively used in the future to improve patient outcomes and manage the growing problem of AMR. For this investigation, a qualitative review of case studies using MT against AMR infections and a quantitative analysis of randomised control trials (RCTs) were performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework. Analysis showed that MT is highly effective against a range of infections and wound types, and compares well against conventional therapies. The low use of MT may be due in part to the documented 'yuck factor', often associated with maggots as well as misconceptions around the cost, efficacy and accessibility of MT. To overcome these factors, more RCTs on the spectrum and efficacy of MT across various clinical manifestations are needed, as well as professional and public engagement campaigns. MT is an underused therapy, particularly regarding AMR infections, and expanding its use in these circumstances appears warranted. MT could play a vital role in conserving the efficacy of the existing pool of antimicrobials available and should be considered in the development of antimicrobial stewardship programmes. This work was supported by the Swansea Employability Academy, Swansea University (internal funding). The authors have no conflicts of interest to declare.

Optimal Allocation of Hybrid Energy Storage Capacity Based on ISSA-Optimized VMD Parameters

To address the issue where the grid integration of renewable energy field stations may exacerbate the power fluctuation in tie-line agreements and jeopardize safe grid operation, we propose a hybrid energy storage system (HESS) capacity allocation optimization method based on variational mode decomposition (VMD) and a multi-strategy improved salp swarm algorithm (ISSA). From typical wind load power and contact line agreement power, the HESS power is obtained. VMD decomposes this power into high- and low-frequency power, respectively, for the super capacitor and the Li-ion battery. Considering charging and discharging power and state of charge (SOC) constraints, an optimization model minimizing the system equivalent annual value cost is established. ISSA optimizes the best decomposition layer K and penalty coefficients α in VMD. The optimal cut-off point and corresponding energy storage allocation scheme are analyzed. A simulation and analysis on MATLAB show that the proposed ISSA-VMD HESS capacity allocation scheme saves 7.53% in costs compared to an empirical mode decomposition (EMD) scheme, proving the method’s effectiveness and superiority.

Nanomaterial strategies in wound healing: A comprehensive review of nanoparticles, nanofibres and nanosheets

AbstractWound healing is a complex process that orchestrates the coordinated action of various cells, cytokines and growth factors. Nanotechnology offers exciting new possibilities for enhancing the healing process by providing novel materials and approaches to deliver bioactive molecules to the wound site. This article elucidates recent advancements in utilizing nanoparticles, nanofibres and nanosheets for wound healing. It comprehensively discusses the advantages and limitations of each of these materials, as well as their potential applications in various types of wounds. Each of these materials, despite sharing common properties, can exhibit distinct practical characteristics that render them particularly valuable for healing various types of wounds. In this review, our primary focus is to provide a comprehensive overview of the current state‐of‐the‐art in applying nanoparticles, nanofibres, nanosheets and their combinations to wound healing, serving as a valuable resource to guide researchers in their appropriate utilization of these nanomaterials in wound‐healing research. Further studies are necessary to gain insight into the application of this type of nanomaterials in clinical settings.

The efficacy of topical oxygen therapy for wound healing: A meta-analysis of randomized controlled trials and observational studies.

In preclinical studies, topical oxygen treatment (TOT) was shown to enhance wound healing by applying supplemental oxygen topically to the surface of a moist wound at normobaric conditions. The objective of this systematic review and meta-analysis is to provide a thorough evaluation of published RCTs and observational studies that compare supplemental TOT with standard wound care. A total of 1077 studies were obtained from a variety of databases, including PubMed, ScienceDirect, Web of Science, ProQuest, Scopus, ClinicalTrials.gov, EU Clinical Trial Registers, and Preprints.org. The Jadad scale was employed to assess the reliability of RCT studies, while the Newcastle-Ottawa Scale (NOS) was employed to assess the quality of observational studies. Seven RCT studies (n = 692) and two controlled observational studies (n = 111) were analysed. The rate of healed wounds was 25.8% in the control group and 43.25% in the adjuvant TOT group, which shows the use of TOT significantly increased the number of healed wounds (RR = 1.77; 95% CI 1.18-2.64; p = 0.005). A significant decrease in the percentage of wound area was found in the TOT group in RCT studies (mean difference = 15.64; 95% CI 5.22-26.06; p = 0.003). In observational studies, the rate of healed wounds was 37.5% in the standard care group and 80.95% in the adjuvant TOT group, which shows a significant increase in the number of healed wounds in the adjuvant TOT group (RR = 2.15; 95% CI 1.46-3.15; p < 0.00001). Topical oxygen therapy is considered a great adjuvant therapy for chronic wound healing, particularly wounds with vascular compromise such as diabetic ulcers and pressure ulcers. Further studies on this topic are still needed as there are a lot of potential uses for this technology in various types of wounds.

Incorporation of natural and synthetic polymers into honey hydrogel for wound healing: A review.

The difficulty in treating chronic wounds due to the prolonged inflammation stage has affected a staggering 6.5 million people, accompanied by 25 billion USD annually in the United States alone. A 1.9% rise in chronic wound prevalence among Medicare beneficiaries was reported from 2014 to 2019. Besides, the global wound care market values were anticipated to increase from USD 20.18 billion in 2022 to USD 30.52 billion in 2030, suggesting an expected rise in chronic wounds financial burdens. The lack of feasibility in using traditional dry wound dressings sparks hydrogel development as an alternative approach to tackling chronic wounds. Since ancient times, honey has been used to treat wounds, including burns, and ongoing studies have also demonstrated its wound-healing capabilities on cellular and animal models. However, the fluidity and low mechanical strength in honey hydrogel necessitate the incorporation of other polymers. Therefore, this review aims to unravel the characteristics and feasibility of natural (chitosan and gelatin) and synthetic (polyvinyl alcohol and polyethylene glycol) polymers to be incorporated in the honey hydrogel. Relevant articles were identified from databases (PubMed, Google Scholar, and Science Direct) using keywords related to honey, hydrogel, and polymers. Relevant data from selected studies were synthesized narratively and reported following a structured narrative format. The importance of honey's roles and mechanisms of action in wound dressings were discussed. Notable studies concerning honey hydrogels with diverse polymers were also included in this article to provide a better perspective on fabricating customized hydrogel wound dressings for various types of wounds in the future. Honey's incapability to stand alone in hydrogel requires the incorporation of natural and synthetic polymers into the hydrogel. With this review, it is hoped that the fabrication and commercialization of the desired honey composite hydrogel for wound treatment could be brought forth.

Research on Transformer Multiple Fault Detection Based on Pulse Coupled Injection

Abstract The fault diagnosis method of winding deformation based on pulse coupling injection is becoming more and more popular due to its advantages of online detection. In order to further improve the method, a pulse generator with adjustable parameters is developed in this paper to provide stable excitation. Its amplitude is adjustable from 600v to 5000v, pulse width is adjustable from 100 to 1000ns, and frequency is adjustable from 1 to 20kHz. In the diagnosis of winding deformation, the current research mainly focuses on the single deformation fault, and rarely involves the mixed deformation fault. Therefore, based on the pulse coupling injection method, field experiments are carried out to verify the feasibility of the method and find out the important reasons affecting the curve. At the same time, the detection experiment of multi-winding deformation fault superposition of a transformer is carried out, and the RVM frequency divider is used to accurately diagnose the mixed fault types of transformer windings.

Probing the Shock Breakout Signal of SN 2024ggi from the Transformation of Early Flash Spectroscopy

We present early-time, hour-to-day cadence spectroscopy of the nearby Type II supernova (SN II) 2024ggi, which was discovered at a phase when the SN shock had just emerged from the red supergiant (RSG) progenitor star. Over the first few days after the first light, SN 2024ggi exhibited prominent narrow emission lines formed through intense and persistent photoionization of the nearby circumstellar material (CSM). In the first 63 hr, spectral lines of He, C, N, and O revealed a rapid rise in ionization as a result of the progressive sweeping up of the CSM by the shock. The duration of the IIn-like spectra indicates a dense and relatively confined CSM distribution extending up to ∼4 × 1014 cm. Spectral modeling reveals that a CSM mass-loss rate at this region exceeding 5 × 10−3 M ⊙ yr−1 is required to reproduce low-ionization emissions, which dramatically exceeds that of an RSG. Analyzing the Hα emission shift implies the velocity of the unshocked outer CSM to be between 20 and 40 km s−1, matching the typical wind velocity of an RSG. The differences between the inner and outer layers of the CSM and an RSG progenitor highlight a complex mass-loss history before the explosion of SN 2024ggi.

Sternal wound types after median sternotomy and reconstruction using dead space-based approach.

This study aims to classify wound complications after median sternotomy and provide an up-to-date reconstructive algorithm for multidisciplinary use. A total of 15 patients (9 males, 6 females; mean age: 68±5 years; range, 60 to 75 years) who underwent sternal reconstruction for wound complications following median sternotomy between August 2020 and October 2023 were retrospectively analyzed. Wound complications requiring reconstruction were classified into three categories based on the extent of the dead space caused by sternal debridement. Type 1, 2, and 3 wounds presented with only skin defects and an intact sternum, with partial and total sternectomy, respectively. The time to consultation for plastic surgery and the duration of hospitalization were compared. Among the wounds, type 2 wounds were the most common type seen in 11 patients. Two patients each had type 1 and type 3 wounds. A superior epigastric artery perforator skin flap was used for type 1 wounds. Bilateral pectoral and split pectoral turnover muscle flaps from the side where the internal mammary artery was intact were used for type 2 wounds. A rectus abdominis muscle flap was used for type 3 wounds. Early consultation from plastic surgery reduced the length of hospital stay. For type 1 wounds, skin flaps ensured sufficient coverage as they involved skin and subcutaneous fat, matching the defect. However, sternal excision required muscle flaps to fill the dead space, in which the vital organs were exposed.

Formulation and Evalution of Polyherbal Ointment for Wound Healing and Anti-Microbial Activity

AIM: Formulation And Evaluation Of Poly Herbal Ointment For Wound Healing And Anti-Microbial Activity Objective: Any physical harm involving tearing, cutting, or puncturing the skin is called a wound.. Numerous medications derived from plants have been shown to speed up the healing of various wound types. The goal of the current study was to create a herbal formulation with herbs that have been shown to improve cell migration and proliferation as well as reduce infection and inflammation and speed up the healing process. The use of herbal medicines and interest in them has grown significantly in recent years, even in places with access to contemporary medical care. Because medicinal plants are the richest source of plant-derived compounds and herbal medicines, there has been a recent surge in interest in these products due to their wide range of applications. MATERIAL AND METHOD: The goal of this work is to manufacture and assess an ointment made of extracts from turmeric (Curcumalonga) and neem (Azadirachta indica).The maceration process was utilized to create the ethanolic extracts.After preparing the ointment base, the extract was incorporated into it using the levigation procedure to formulate the ointment. Its physicochemical properties, such as color, odor, pH, spreadability, extrudability, consistency, diffusion studies, solubility, and washability, were assessed once the formulation was finished. Additionally, the formulation's stability at different temperature circumstances was assessed, and the results of the diffusion, spreadability, and irritancy studies remain unchanged. Thus, it might develop into a medium for utilizing the therapeutic qualities of turmeric and neem in an easy-to-use dose form