Although international recommendations corroborate the antihypertensive effects of regular endurance training (ET), interindividual responses are widely heterogeneous, differing between responders (RE) and non-responders (NR). Previous studies have shown the decrease in the activity of the autonomic nervous system (ANS) is involved in the ET-induced reduction of blood pressure (BP). However, it is not yet known whether this mechanism is related to the variability of BP response. PURPOSE: Associate baseline ANS variables with interindividual BP responses in hypertensive women undergoing ET. METHODS: Forty-four women performed 12 weeks of ET on cycle ergometer (50 min.day-1, 3 days.week-1 at 60-70% heart rate reserve). Pre and post ET 20 min beat-to-beat BP waveforms were recorded by finger photoplethysmography and ANS was assessed by heart rate (HR) variability (HRV) recorded from HR monitor and analyzed in the time and frequency domain. Participants were identified as RE by a magnitude of reduction in systolic BP (SBP) greater than the typical error (TE) of measurement (1xTE=7.4 mmHg) and participants with changes less or increase greater than 1xTE as NR. Associations between baseline HRV variables and changes (Δ) in BP after ET were analyzed using Pearson’s correlation coefficient and multiple linear regression. Student's t-test to comparisons RE vs. NR. Receiver operator characteristic (ROC) curve to identify predictors cut-off values for RE and NR discrimination. RESULTS: Ten individuals were considered RE (Δ=-15.6±7.6 mmHg) and 34 NR (Δ=4.3±7.9 mmHg). SBP changes were correlated with: SDNN (r=0.395; p=0.008), RMSSD (r=0.384; p=0.010), LF (r=0.318; p=0.036) and HF (r=0.348; p=0.02). SDNN was able to predict 15.6% of variance in SBP changes (β=0.39, p=0.008). Compared to RE, NR demonstrated greater SDNN (29.6±21.4 vs. 16.1±4.9, p=0.09), RMSSD (32.7±27.3 vs. 17.4±8.6, p=0.013) and LF (591±1380 vs. 110±71, p=0.001) and HF (668±1340 vs. 154±164, p=0.012). For SDNN, a cut-off value of 18.7 discriminated RE and NR with good accuracy (AUC=0.81, sensitivity=80%, specificity=76%, p=0.03). CONCLUSION: Baseline cardiac autonomic function can predict interindividual SBP responses to ET. Predictors cut-off values could be used to determine whether patients with hypertension are likely to benefit from ET.