The variation in suspended sediment concentration (SSC) has an important impact on the protection of estuarine shoal wetlands and the maintenance of waterways. Typhoons (tropical cyclones), one of the most severe meteorological disasters, frequently occur along the southeastern coasts of China and substantially affect the spatial-temporal distribution of SSC in the Yangtze Estuary. In this study, the spatial-temporal distribution of SSC was observed at high frequency through hourly geostationary satellite remote sensing during four typhoon events, namely, Typhoons Damrey/Saola (August 2012), Soulik (July 2013), Matmo (July 2014) and Dujuan (September 2015). Such observation is difficult to achieve through in situ approaches due to the unsafe working conditions created by typhoon winds. Moreover, wind speed, wave height and period, and bottom shear stress (BSS) data combined with turbidity data were used to analyze the causes of typhoon-induced SSC variations. The results indicated that the average wind-driven significant wave height during typhoons was 2.1-fold higher than that in pre-typhoon periods. In the lower mouth of the Yangtze Estuary and in Hangzhou Bay, the SSC increased by 0.14–0.33 g/L, whereas in the upper mouth, the SSC was less affected by wind. The significant increase in SSC persisted for 1–2 days following typhoon transit. With the assistance of the FVCOM model, it was observed that the enhanced wave-current dynamics and increased BSS during the typhoons were the main reasons for the sharp increase in SSC. Moreover, it was inferred from the satellite images that sediment exchange occurs between channels and shoals during a typhoon, which affects the SSC distribution for up to one month.