Typhoid Co-infection Research Articles

A mathematical model of Cholera–Typhoid coinfection dynamics with a hygiene-driven contact rate

Waterborne infections such as Cholera and Typhoid remain a huge burden on the public health systems of poor countries in Africa and Asia. The highest disease burden is concentrated in sub-Saharan Africa. In most regions, the recent spike in cases of both infections is attributed to dilapidated infrastructure and poor hygiene. This paper examines the role of poor hygiene in the surge of both infections. We use a system of non-linear ordinary differential equations to model the movement of people between the different classes of infections, and we use a sigmoidal function to model the different levels of hygiene in a community. The findings demonstrate that managing hygiene, even if limited to the direct transmission route, can significantly reduce the prevalence of both infections. This paper presents some of the public health implications of these findings.

Malaria and typhoid fever co-infection: disease severity and immune response

Malaria and typhoid fever co-infection: disease severity and immune response

Malaria and typhoid fever co-infection: a retrospective analysis of University Hospital records in Nigeria

BackgroundStudies have long documented the presence of malaria and typhoid fever in sub-Saharan Africa (SSA). However, studies on these diseases have primarily concentrated on rural settings, neglecting the potential impact on urban areas. This knowledge gap hinders effective surveillance and intervention strategies. To bridge this gap, this study investigated the prevalence of malaria and typhoid co-infections in an urban environment.MethodsThis study, conducted at Lead City University Hospital in Ibadan, Nigeria (West Africa’s largest metropolis), analysed medical records of over 3195 patients seen between April and June 2023. Descriptive statistics and chi-square tests were used to understand how these co-infections were distributed across different age and gender groups.ResultsThe prevalence of co-infection peaked in May (9.7%), followed by June (8.9%) and April (5.7%). Notably, children aged 6–12 years exhibited the highest co-infection rate (18.5%), while those under five had the lowest (6.3%). Gender analysis indicated a slight difference, with 8.8% of females and 7.1% of males co-infected. Malaria prevalence was highest at the beginning of the rainy season and significantly decreased over time. Conversely, typhoid fever displayed the opposite trend, increasing with the rainy season. Children under five years old were most susceptible to malaria, while typhoid fever predominantly affected adults over 25 years old, with prevalence decreasing significantly with age.ConclusionThis study sheds light on the previously overlooked risk of malaria and typhoid co-infections in urban settings. These findings highlight the need for enhanced surveillance and targeted public health interventions, particularly for vulnerable groups like young children during peak transmission seasons.

Malaria and Typhoid Fever Coinfection among Febrile Patients Attending Kafin-Maiyaki Primary Health Centre

Study’s Novelty/Excerpt This study investigates the burden and co-existence of malaria and typhoid fever among febrile patients, providing a rare examination of these symptomatically similar but aetiologically distinct diseases in a single patient cohort. The novelty of the research lies in its detailed analysis of co-infection rates across different age groups and genders, highlighting significant age-related disparities and suggesting the higher vulnerability of older patients. These findings underscore the importance of concurrent screening for malaria and typhoid fever in febrile patients, offering critical insights for improving diagnostic and treatment strategies in the study area. Full Abstract Malaria and typhoid fever are two symptomatically similar but aetiologically dissimilar diseases: mala ria is caused by parasitic agents from Plasmodium species; ty phoid fever, on the other hand, is caused by Salmonella typhi. They both have no gender distinction in terms of their effect, but malaria appears to be more severe among children. The study aimed to determine the burden of these two diseases among febrile patients in the study area by collecting four (4) mL of blood from each participant, 2 mL of which were dispensed into EDTA bottles for use to detect microscopic parasites. The harvested serum from the remainder was used for the Widal agglutination test to detect the presence of antibodies to Salmonella species. Based on the results, malaria and typhoid fever co-existence was found to be 20.9%. The findings with respect to age group revealed that patients >60 years had a higher coinfection rate of 75% while the 1-12 years age group had the least coinfection (10.6%). There was a significant association between coinfection and age groups (p = 0.019). With respect to gender, females were more prone to be co-infected (53.6%) compared to their male counterparts (46.4%) out of the total positive cases (28) obtained, but the observed difference was not statistically significant (p = 0.016). We therefore recommend concurrent screening of these diseases in all febrile cases in the study area.

Malaria and Typhoid Co-Infection among Children under 5 Years of Age at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Anambra State, Nigeria

This study sheds light on the prevalence of malaria and typhoid in children below the age of five in a hospital in Nigeria. This study aimed to determine the presence of malaria, typhoid and malaria-typhoid co-infection in children less than five years of age. In this community-based descriptive, quantitative and cross-sectional hospital-based survey, the blood samples of 125 children between 0 to less than 5 years (68 males and 57 females) were examined for the presence of malaria parasites and typhoid infection. Blood samples were collected using venepuncture. The malaria parasitaemia was detected using malaria microscopy on a thick blood film. Typhoid fever infection was detected using the Widal Agglutination Test. The chi-square test was used to compare the prevalence of malaria, typhoid fever and malaria/typhoid co-infections between male and female infected and uninfected participants and between children below 1 year and those 1 year and above. P-values less than 0.05 were considered significant. A prevalence of 47.2%, 32% and 16% were recorded for malaria, typhoid and malaria/typhoid co-infection respectively. A mean malaria parasite intensity of 56.8475 (±3.30177) was recorded. There was no significant difference between the prevalence of malaria, typhoid and malaria/typhoid co-infection between the genders and age groups. Also, there was no significant difference between the mean PCV of the infected (33.1610 (±0.80748) and uninfected (34.6667 (0.48441) (P> 0.05). These results underscore the importance of continued efforts to combat these diseases and improve the health and well-being of children in the region.

Global stability and Sensitivity Analysis of Malaria, Dengue and Typhoid Triple Infection

This study investigates the global stability of the endemic equilibrium point of triple co-infection of malaria, dengue, and typhoid. By using an appropriate Lyapunov function, the results show that the model is globally asymptotically stable. This implies that the diseases can be eradicated or kept at low levels, regardless of the population. Sensitivity analysis was also conducted to identify the most sensitive parameter. The results indicate that strategies to reduce malaria and dengue fever vectors should be prioritized to curb the spread of the diseases. Additionally, minimizing exposure to contaminated water and food, as well as reducing the discharge of typhoid bacteria into the environment, can help to reduce or curb the spread of typhoid in the environment.

Modeling the Impact of Contaminated Environments on the Transmission Dynamics of COVID-19 and Typhoid Fever Co-Infection Diseases

Modeling the Impact of Contaminated Environments on the Transmission Dynamics of COVID-19 and Typhoid Fever Co-Infection Diseases

Malaria and Typhoid Fever Coinfection among Febrile Patients in Ngaoundéré (Adamawa, Cameroon): A Cross-Sectional Study.

Malaria and typhoid fever remain the major cause of morbidity and mortality in tropical and subtropical countries. It is common today to see patients being concurrently infected or treated for the two diseases. The aim of the present study was to determine the prevalence of malaria, typhoid fever, and their coinfection among febrile patients at Ngaoundéré Regional Hospital, Adamawa, Cameroon. Methodology. A cross-sectional and descriptive study was conducted on 208 febrile patients coming for medical consultation at Ngaoundéré Regional Hospital and suspected for malaria and/or typhoid fever from September to November 2019. After receiving the consent of each patient, clinical and sociodemographic information were collected using a pretested semistructured questionnaire. Thereafter, blood samples were collected and subjected to (i) blood film examination for malaria detection and (ii) qualitative and semiquantitative Widal assay for typhoid fever detection. Plasmodium falciparum was the only species identified, and the prevalence of malaria was 50.0% (n = 104). The seroprevalence of typhoid fever was 64.3% (n = 133). The malaria and typhoid fever coinfection was 30.3% (n = 63). The coinfection between S. paratyphi (A, B, and C) and malaria was also observed with the prevalence ranging from 32.2 to 63.9%. Female group and children from 2 to 10 years old were the most affected groups by the two infectious agents. Typhoid fever and malaria were more prevalent in Ngaoundéré City, particularly in children and women. Further studies should be done on the risk factors of malaria and typhoid fever coinfection in different study areas.

Incidence of malaria and typhoid fever co-infection among patients attending Rimingado Comprehensive Healthcare Centre, Kano State, Nigeria.

The research was carried out to determine the incidence of malaria-typhoid co-infection among patients attending Rimingado comprehensive healthcare centre, Kano state, Nigeria. Patients’ bio- data were obtained through structured questionnaire and diagnosis was done using venous blood sample obtained from the participants. Rapid diagnostic test was used for analysis of malaria parasites while widal test was used for the analysis of enteric fever. Of the 150 patients enrolled for the study (85 females and 65 males), 60 (40.0%) had malaria and typhoid fever co-infection (P<0.05). The incidence of malaria-typhoid co-infection was highest among those in the age group range between 11-20 years (12.0%). However, with regard to the marital status, those that were single had the highest incidence of coinfection (27.3%) than the married. Poor sanitary habits, poverty and ignorance are the predisposing factors for the development of malaria and typhoid infections.

Burden of Dengue–Typhoid Coinfection in Pediatric Patients: A 6-year Experience from a Tertiary Care Center

Burden of Dengue–Typhoid Coinfection in Pediatric Patients: A 6-year Experience from a Tertiary Care Center

Malaria and typhoid fever among patients presenting with febrile illnesses in Ga West Municipality, Ghana.

Clinicians in areas where malaria and typhoid fever are co-endemic often treat infected patients irrationally, which may lead to the emergence of drug resistance and extra cost to patients. This study determined the proportion of febrile conditions attributable to either malaria and/or typhoid fever and the susceptibility patterns of Salmonella spp. isolates to commonly used antimicrobial agents in Ghana. One hundred and fifty-seven (157) febrile patients attending the Ga West Municipal Hospital, Ghana, from February to May 2017 were sampled. Blood samples were collected for cultivation of pathogenic bacteria and the susceptibility of the Salmonella isolates to antimicrobial agents was performed using the Kirby-Bauer disk diffusion method with antibiotic discs on Müller Hinton agar plates. For each sample, conventional Widal test for the detection of Salmonella spp was done as well as blood film preparation for detection of Plasmodium spp. Data on the socio-demographic and clinical characteristics of the study participants were collected using an android technology software kobo-collect by interview. Of the total number of patients aged 2-37 years (median age = 6 years, IQR 3-11), 82 (52.2%) were females. The proportion of febrile patients with falciparum malaria was 57/157 (36.3%), while Salmonella typhi O and H antigens were detected in 23/157 (14.6%) of the samples. The detection rate of Salmonella spp in febrile patients was 10/157 (6.4%). Malaria and typhoid fever coinfection using Widal test and blood culture was 9 (5.7%) and 3 (1.9%), respectively. The isolates were highly susceptible to cefotaxime, ceftriaxone, ciprofloxacin, and amikacin but resistant to ampicillin, tetracycline, co-trimoxazole, gentamicin, cefuroxime, chloramphenicol, and meropenem. Plasmodium falciparum and Salmonella spp coinfections were only up to 1.9%, while malaria and typhoid fever, individually, were responsible for 36.3% and 6.4%, respectively. Treatment of febrile conditions must be based on laboratory findings in order not to expose patients to unnecessary side effects of antibiotics and reduce the emergence and spread of drug resistance against antibiotics.

Dengue and typhoid co-infection: a case report from a tertiary care hospital in Puducherry

Acute undifferentiated febrile illness is the most common presenting symptom in both adults and children during the monsoon. Incidence of both vector- and water-borne diseases are highest during these seasons, co-infections of dengue with typhoid, malaria, leptospirosis, scrub typhus and other arboviruses can occur in endemic areas. We report the case of a 3-year-old child who presented with dengue and typhoid fever coinfection and subsequently recovered. In every febrile patients’ common infections should be evaluated with through history, clinical examinations and logical investigations. If not treated early, dengue and typhoid together, may lead to multi-organ involvement with significant morbidity and mortality.

The Rate Of Malaria Parasites Co –infection Salamoella TyphO And Para- Typhi BO In Khartoum State

Background: .
 Malaria is serious vector –borne tropical diseases that remains one of the primary reasons for death in several countries . Malaria and typhoid co-infection is a major public health problem in many developing countries. Most of the co-infections treated are based on methods of diagnosis plagued with assumptions which possibly exaggerate the situation. Objective: This the aim of this work was to investigate the rate of co-infection with respect to the use of direct Widal test for diagnosing typhoid fever in Khartoum state .
 Method: This was based descriptive cross-sectional malaria of Plasmodium falaciprum and Salamoella . A total of 100 blood samples were collected from patients with a clinical of malaria positive and examined for malaria parasites and S. typhi infection.
 Results: This study was conducted in Khartoum State between 2020 to 2021 in individual form different age groups form both male and female, out of 100 samples were positive for malaria parasites(Plasmodium falciprum) by blood films (100%) and immunochormatogrphy test 80(80%) , 52(52%) of which were positive for salmonella typhiO and 18(18%) salmonella para- typhi BO by the direct Widal test.

COVID-19 and Coinfections: A Serious Health Threat Requires Combination of Diagnosis and Therapy.

Since the advent of the COVID-19 pandemic in 2019, a mammoth research activity targeting the etiological features of COVID-19 has commenced. Many aspects of the disease have been studied, and various others are under consideration. The secondary microbial coinfections with COVID-19 have generated some serious concerns across the globe. This review mainly focuses on the notable secondary coinfections. The coinfection of influenza, tuberculosis, and typhoid may mimic the original COVID-19 symptoms. Physicians and clinicians must focus on the secondary coinfections which may aggravate the disease progression towards acute respiratory disorder syndrome (ARDS). Diagnostic strategies must also be redefined to determine the actual underlying secondary coinfection. There is a need for combination therapy and diagnostic approaches to minimize the risks associated with the COVID-19 pandemic effectively.

Prevalence of malaria and typhoid fever co-infection among pregnant women attending antenatal clinic in Anyigba, Kogi State, Nigeria

Prevalence of malaria and typhoid fever co-infection among pregnant women attending antenatal clinic in Anyigba, Kogi State, Nigeria

Mathematical analysis of cholera typhoid co-infection transmission dynamics

Typhoid fever and cholera remain a huge public health problem on the African continent due to deteriorating infrastructure and declining funding for infrastructure development. The diseases are both caused by bacteria, and they are associated with poor hygiene and waste disposal systems. In this paper, we consider a nonlinear system of ordinary differential equations for the co-infection of typhoid and cholera in a homogeneously mixing population. The model's steady states are determined and analyzed in terms of the model's reproduction number. Impact analysis—how the diseases impact on each other—is carried out. Numerical simulations and sensitivity analysis are also given. The results show that the control of the diseases should be carried out in tandem for the greatest impact of disease control. The results have important implications in the management of the two diseases.

Assessment of co-infection of typhoid and malaria in patients attending F.M.C Umuahia Abia state

Malaria and typhoid fever are major public health problems in tropical and subtropical countries. People in endemic areas are at risk of contracting both infections concurrently. This study was aimed at assessing malaria and co-infection of typhoid fever among patients. A cross-sectional study was conducted on 256 patients suspected for malaria and typhoid fever from March to August 2017 at Federal Medical Centre Umuahia Abia State. Blood samples were collected for blood film preparation and widal test. The prevalence of malaria was 78.90% (n = 202). Among these age groups, (11 – 15), (16 – 20), (21 – 25) and (26 – 30) years were mostly infected. The seroprevalence of typhoid fever was found high and poor hand washing habit were associated with typhoid fever infection. Further studies should be done on malaria and typhoid fever co-infection in different seasons and different study areas.

Dengue and Typhoid co-infection Study

Undifferentiated acute febrile illness is a common presentation specially during monsoons in India.The overlapping presentations of arboviruses and vector borne diseases have been noted in endemic areas with increasing incidences. There have been rare reports of these presentations with overlapping symptoms making the final nailing of diagnosis further difficult. The exact incidence of dengue and typhoid co-infection is not known and the similarity of symptoms, makes accurate clinical diagnosis and treatment difficult without a laboratory confirmation. Meticulous history taking, careful clinical examination and right choice of laboratory tests for the diagnosis of these co-infections not only helps in timely diagnosis but also prevents fatal outcomes. Keywords: Concurrent infection, Dengue, Febrile, Typhoid.

Molecular characterization of the severe falciparum malaria with typhoid co-infection: A case report

Malaria and typhoid co-infections can be a serious public health issue in tropical countries leading to incorrect diagnosis due to overlapping clinical presentations of malaria and typhoid and hence, causing a delay in implementing the appropriate treatment regimen for these concurrent infections. This study reports a case of six-year-old female child co-infected with severe malaria (Plasmodium falciparum) and typhoid (Salmonella typhi) diagnosed by rapid malaria antigen test (RMAT) and blood culture respectively. Further, analysis of the chloroquine resistance gene Pfcrt for the falciparum demonstrated the presence of K76T mutant allele in pfcrt gene with high IC50 (150nM) for chloroquine (CQ) drug. The present case highlights the significance of timely identification and treatment of co-infections and also provides information about the circulating P. falciparum clinical strains.

Perioperative Challenge in Anesthetic and Pain Management in a Case of Hepatitis E and Typhoid Co-infection with Acute Liver Failure and Ileal Perforation: a Case Report and Review of Literature

Perioperative Challenge in Anesthetic and Pain Management in a Case of Hepatitis E and Typhoid Co-infection with Acute Liver Failure and Ileal Perforation: a Case Report and Review of Literature