Type Research Articles

Nonrandom Chromosomal Abnormalities in Acute Nonlymphocytic Leukemia in Patients Treated for Hodgkin Disease and Non-Hodgkin Lymphomas

Chromosomal analyses of myeloid cells were performed on ten patients who had acute nonlymphocytic leukemia (ANLL) following treatment for malignant lymphoma. Seven patients had Hodgkin disease and three had non-Hodgkin lymphoma, poorly differentiated lymphocytic type. Six patients were treated with radiotherapy and chemotherapy; two had radiotherapy only, and two chemotherapy only. The median time between diagnosis of lymphoma and subsequent leukemia was 58 mo. Four patients had the blast phase of a myeloproliferative syndrome, four had acute myelogenous leukemia, one had acute promyelocytic leukemia, and the tenth, erythroleukemia. None of four patients whose leukemia was treated with intensive chemotherapy responded. Every patient had an abnormal karyotype. Seven of the patients showed hypodiploid cell lines, two a pseudodiploid, and one a hyperdiploid cell line. Cells from every patient except one were lacking a B chromosome; in eight, this could be identified as a No. 5. Five of nine patients were lacking a No. 7. Loss or rearrangement of No. 17 was found in four and of Nos. 6 or 8 in three patients. Many of the karyotypes were bizarre, with marker chromosomes and minute chromosomes. The karyotypic pattern seen in these patients showed no correlation with the nature of the originalmore » lymphoma, the type of leukemia, or the therapy used. The chromosomal pattern of hypodiploid cell lines found in ANLL that arose de novo was similar to that occurring in treated lymphoma. However, in ANLL de novo, less than half of the patients had fewer than 46 chromosomes, and less than 10% had fewer than 45 chromosomes. In this study, 70% of the patients had fewer than 46 and 40% had fewer than 45 chromosomes. The critical question thus concerns the factors, as yet unknown, that predispose to the development of hypodiploid modal numbers in ANLL in lymphoma.« less

Functionally defined CD164 epitopes are expressed on CD34(+) cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues.

Three distinct classes of epitopes on human CD164 have been identified. Two of these, recognized by the monoclonal antibodies 105A5 and 103B2/9E10, are the CD164 class I and class II functionally defined epitopes, which cooperate to regulate adhesion and proliferation of CD34(+) cell subsets. In this article, we demonstrate that these 2 CD164 epitopes are expressed on CD34(+) cells throughout ontogeny, in particular on CD34(+ )cell clusters associated with the ventral floor of the dorsal aorta in the developing embryo and on CD34(+) hematopoietic precursor cells in fetal liver, cord blood, and adult bone marrow. While higher levels of expression of these CD164 epitopes occur on the more primitive AC133(hi)CD34(hi)CD38(lo/-) cell population, they also occur on most cord blood Lin(-)CD34(lo/-)CD38(lo/- )cells, which are potential precursors for the AC133(hi)CD34(hi)CD38(lo/-) subset. In direct contrast to these common patterns of expression on hematopoietic precursor cells, notable differences in expression of the CD164 epitopes were observed in postnatal lymphoid and nonhematopoietic tissues, with the class I and class II CD164 epitopes generally exhibiting differential and often reciprocal cellular distribution patterns. This is particularly striking in the colon, where infiltrating lymphoid cells are CD164 class I-positive but class II-negative, while epithelia are weakly CD164 class II-positive. Similarly, in certain lymphoid tissues, high endothelial venules and basal and subcapsular epithelia are CD164 class II-positive, while lymphoid cells are CD164 class I-positive. It therefore seems highly likely that these CD164 class I and II epitopes will mediate reciprocal homing functions in these tissue types.

Tavuk Gübresinden Amonyak Gazı Emisyonunun Azaltılmasına Yönelik Uygulamalar

Kanatlı hayvanların tükettikleri proteinler; pH‘a, sıcaklığa, altlığın nem içeriğine, altlık türüne, gübrenin durumuna, bağıl neme ve havalandırma durumuna bağlı olarak mikrobiyal faaliyetler sonucunda amonyağa dönüşmekte ve amonyak gazı olarak çevreye yayılmaktadır. Tavuk yetiştiriciliğinin yol açtığı sorunlardan biri olan amonyak gazı hayvan refahı, çalışanların sağlığı ve çevreye olan etkileri bakımından zararlı bir gazdır. Bu makalede tavukçulukta açığa çıkan amonyak gazı emisyonu ve bu emisyonun azaltılmasına yönelik uygulamalar ele alınarak önerilerde bulunulmuştur.

Development and application of a fundus image quality assessment system based on computer vision technology

Objective: To develop a fundus image quality assessment system based on computer vision technology and to verify its accuracy by comparing the results of artificial discrimination and using this system. Methods: The process of image evaluation was divided into four modules: fundus image preprocessing, fundus image quality evaluation, fundus image content detection and evaluation result output. The system was designed to automatically evaluate the image quality of each fundus image, identify the optic disc and macula, and judge whether the image was qualified or not according to the image quality discrimination rules. A total of 2 397 fundus images of 787 type 2 diabetes patients were selected as the test data set. The average age of the patients, including 384 males and 403 females, was (69.65±19.09) years old. The images were taken by the staff of community health service centers in Shanghai with a fundus camera. The fundus image quality assessment system was used to conduct quality control and classification of the data set. At the same time, 12 professional fundus picture readers were employed to conduct manual quality control and classification of this data set. The system quality control results and artificial quality discrimination results were compared and analyzed. Results: The fundus image quality assessment system automatically recognized left and right eyes and eye positions on the input fundus images. The quality control interface included four indicator lights, which respectively corresponded to the images with the optic disc or macula as the center of the left or right eye. Evaluation of each fundus image was completed within 1 second, and the results were automatically displayed on the user interface. The 2 397 fundus photos were identified manually as 1 846 qualified photos and 551 unqualified photos. Among the unqualified images, 62 (11.27%) were too dark, 51 (9.27%) were too bright, 59 (10.73%) were not clear in the macular area, 36 (6.54%) showed no macula or optic disc, 125 (22.73%) could not present the fundus structure, 175 (31.82%) were blurred, and 42 (7.64%) were blocked. The results of the system and manual assessment were consistent in 1 788 qualified images (96.86%) and 550 unqualified images (99.82%), with an overall consistency rate of 97.54%. Conclusion: The fundus image quality assessment system can achieve highly consistent results with the professional judgment of ophthalmologists and has the characteristics of objectivity. (Chin J Ophthalmol, 2020, 56:920-927).

CARACTERIZACIÓN PALINOLÓGICA DE LAS MIELES DE LA LLANURA DEL RÍO SENGUERR (CHUBUT-ARGENTINA)

In order to know the plants used by honeybees in the Senguerr river plains, a palynological analysis of 19 samples of honey was made. Most samples had less than 2000 grains/g. Fifty-seven types of pollen were identified. Main sources of nectar belong to the following families: Fabaceae, Rosaceae, Brassicaceae and Asteraceae. Honeys were classified as monofloral Melilotus sp. (8 samples), monofloral Rosaceae (wild and cultivated, 2 samples) or of mixed floral origin (9 samples). The analized honeys may be distinguished by a pollen association of Trifolieae, Brassicaceae, Rosaceae, Acaena sp., Glycyrrhiza astragalina Gillies ex Hook. & Arn. and Cyperaceae.

Ecg changes in a patient with covid-19 treated with hydroxychloroquine and azithromycin

The study involved a 73-year old patient admitted to our hospital with moderate COVID-19 infection detected during acute coronary syndrome The patient underwent revascularization using stenting of the circumflex artery eight hours after onset of chest pain The patient had a history of type 2 diabetes treated with Metformin and high blood pressure treated with perindopril At first he underwent ECG showing QTc level of 420 ms (corrected according to Bazett’s formula) He received hydroxychloroquine 200 mg three times a day and azithromycin 500 mg/day according to Moroccan COVID-19 treatment protocol in addition to his post-infarct treatment (Clopidogrel 1 tablet of 75 mg once a day;aspirin 1 tablet of 75 mg once a day;atorvastatin 1 tablet of 80 mg once a day, bisoprolol 2 5 mg/day On the 5th day of his hospitalization daily ECG monitoring showed QT interval prolongation of 547 ms (corrected according to Bazett’s formula) with ventricular extrasystole (ECG A) justifying discontinuation of hydroxychloroquine/azithromycin treatment Three hours after, another ECG was performed which showed focal atrial tachycardia with variable conduction and unchanged QTc (ECG B) No hydroelectrolyte imbalance associated with serum potassium 4 1 mmol/l and magnesemia 22mmol/l was detected Outcome was favorable with QT returning to normal values, patient’s transition to paroxysmal atrial fibrillation requiring oral anticoagulation therapy and discharge after 21 days of hospitalization © Mohamed Elghali Benouna et al

KESESUAIAN KONSEP RUANG RITUAL IBADAH BERJAMAAH DENGAN BENTUK ARSITEKTUR MASJID AL-AHDHAR

Abstrak- Indonesia merupakan salah satu negara dengan populasi penganut agama Islam terbesar di dunia. Tingginya jumlah penduduk yang menganut agama Islam menyebabkan tingginya kebutuhan untuk mendirikan masjid yang memiliki fungsi utama sebagai sarana untuk menjalankan kegiatan ibadah di berbagai daerah. Masjid sebagai tempat pertemuan manusia dengan Tuhan-nya idealnya memiliki aspek spasial yang sesuai dengan karakter kegiatan yang dilakukan didalamnya. Kegiatan ritual ibadah shalat berjamaah memiliki persyaratan dan alur gerak tertentu, sehingga memiliki penataan dan karakter yang berbeda dengan arsitektur bangunan lainnya.Seiring dengan berkembangnya zaman, arsitektur masjid semakin beragam. Inovasi struktur dan kemajuan teknologi memungkinkan munculnya variasi bentuk arsitektur masjid yang menarik. Berkenaan dengan hal tersebut, Masjid Al-Ahdhar merupakan salah satu masjid dengan bentuk arsitektur yang unik. Hal ini terlihat dari bentuk bangunan yang memanjang ke arah samping dan tidak berkubah, sehingga tidak seperti arsitektur masjid pada umumnya. Walaupun memiliki bentuk arsitektur yang menarik, perlu diketahui apakah hasil rancangan bentuk dan ruang dalam pada masjid dapat mewadahi fungsi dengan baik. Oleh sebab itu, perlu dilakukan penelitian lebih lanjut mengenai penerapan konsep ruang ritual ibadah berjamaah pada arsitektur masjid.Tujuan penelitian ini adalah mengungkap kesesuaian konsep ruang ritual ibadah berjamaah pada objek studi terpilih, yaitu Masjid Al-Ahdhar. Penelitian dilakukan dengan melakukan penelusuran terhadap aspek-aspek konsep ruang ritual ibadah berjamaah, lalu kemudian menentukan aspek properti dan komposisi bangunan yang sesuai dengan konsep tersebut. Setelah itu, dilakukan evaluasi konsep ruang ritual pada hasil rancangan arsitektur Masjid Al-Ahdhar yang dibagi lingkup pembahasannya berdasarkan teori anatomi bangunan. Hasil penelitian diharapkan dapat memberi kontribusi mengenai aspek spasial dalam masjid. Sehingga, walapun arsitektur masjid memiliki bentuk yang beragam tetap memenuhi persyaratan kegiatan ibadah.

A Short note on Ewings sarcoma

Ewing’s sarcoma was first distinguished as “diffuse endothelioma of bone”. The cause is still unknown the but mostly theories suggest that these tumors arise from a primitive cell obtained either from an embryologic tissue which is called the neural crest, or from mesenchymal stem cells that are capable to become one of a variety of tissue types. Pathologists have studied that Ewing sarcoma is almost alike to an even rarer soft tissue tumor called primitive neuroectodermal tumor (PNET).ES and PNET were having similar features when observed under microscope, in more than 95% of cases also had a similar genetic abnormality called as translocation. Hence they were grouped into class of cancers entitled Ewing’s Sarcoma Family of Tumor (ESFT).This family includes, Ewing’s sarcoma of the bone, Extraosseus Ewing’s sarcoma, Primitive neuroectodermal tumor (PNET),Peripheral neuroepithelioma, Askin’s tumor and Atypical Ewing’s sarcoma. The translocation in ESFT is between chromosomes 11 and 22 and is referred to as t (11;22). The gene from chromosome 22 encodes the Ewing sarcoma gene (EWS) whose function is not well-understood. The gene FLI1 from chromosome 11, is involved in turning other genes on and off. EWS/FLI is a fused gene, which encodes an altered fusion protein which controls the regulation of other genes that can give rise to cancers when inappropriately expressed.

Showing NAFLD, as a key connector disease between Alzheimer’s disease and Diabetes, via systems biology analysis

Aim: Network analysis of Alzheimer and Diabetes and find their correlation with each other and other disease/pathways. Background: Alzheimer’s disease (AD) as a neurodegenerative disease and Diabetes as metabolic disease are two major health problems in recent years. Recent studies reported their correlation and same spreading pathways of these two disease together, but details of this relation at molecular level not well known. Methods: In TPP technique after treatment of extracted proteins by heat and drug concentration, the resulted proteins analyzed by mass spectrometry. Enrichment analysis of these proteins lead to Alzheimer`s and Diabetes. First, the corresponding genes for each disease were extracted from DisGeNET, then, the protein-protein interaction network for each of them were constructed using STRING. After analyzing these networks, the hub-bottleneck nodes of networks were evaluated. Also, common nodes between two networks were extracted and used for further analysis. Results: High correlation between Alzheimer disease and Diabetes by the existence of 40 genes in common. Analyzes, revealed 14 genes in AD and 12 genes in Diabetes as hub-bottleneck which seven of them were common including: CASP3, IGF1, CAT, TNF LEP, VEGFA and IL6. Conclusion: This study, revealed a direct correlation between AD and Diabetes also the correlation between these two diseases and NAFLD, suggesting small change in each three diseases can develop any other disease in patients. Also the enrichments exhibited existence of common pathways between AD, Diabetes, NAFLD and mail fertility. Key words: NAFLD, Alzheimer's Disease, Diabetes Mellitus, Type II, Male Infertility, Bioinformatics

Monoclonal Antibodies Treatment

EAntibodies are naturally produced by the immune system when it detects something harmful. Antibodies are the proteins which act to certain infection by attaching themselves to antigens. The synthetic antibodies are produced in the laboratory which act against proteins that attack normal tissues. Production of synthetic antibodies involves introducing human genes that produce antibodies into mice or any another suitable mammal and later those mice are vaccinated with the antigen for which antibodies are required to be produced, which leads to the production of desired human antibody by the immune cells of the mice. These synthetic antibodies which are produced in the lab are termed as monoclonal antibodies which are synthesized from cloned immune cells. The use of monoclonal antibodies in treating a disease is called immunotherapy where each type of monoclonal antibody is produced to target a specific antigen in the body

The Differences in Smartphone Addiction Symptoms between Highly Addicted and Non-addicted among Middle School Students by Types of Risk Groups

The Differences in Smartphone Addiction Symptoms between Highly Addicted and Non-addicted among Middle School Students by Types of Risk Groups

Pengaruh Tipe Infill dan Temperatur Nozzle terhadap Kekuatan Tarik Produk 3D Printing Filamen Pla+ Esun

The increasing technology of the manufacturing industry now makes the industry competition, especially in the field of manufacturing increasingly stringent in developing products with accurate dimensions. The process of getting accurate and precise dimension results is very important in improving the quality of a product to be made. With the development of this technology, the manufacturing industry has begun to develop products with the method of adding materials known as rapid prototyping or layer manufacturing, one of which is technology using 3D printing machines. This research was carried out on a PRUSA 3D Printing FDM model with dimensions of 220 mm x 220 mm x 250 mm and using a nozzle measuring 0.4 mm. The material used is a PLA + filament with a diameter of 1.75 mm with variations in the nozzle temperature parameters (205 ° C, 215 ° C, 225 ° C), layer thickness 0.2, bed temperature 60 ° C, travel speed 100, printing speed 50 , infill type (Grid, Lines, Triangles, Tri Hexagon, Cubic, Cubic Subdivision, Octet, Quarter Qubic, Concentric, Zig Zag, Cross, Cross 3D, Gyroid) which will be determined in Ultimaker Cura 4.4.0 software, resulting in 39 printed sample. The results obtained after testing the highest tensile strength values are found in the 22nd test specimen that is 43.20 MPa with 215 nozzle temperature parameters and Infill Type Concentric, while the lowest tensile strength values are found in the 22nd test specimen which is 24.50 MPa with nozzle temperature parameters 205 ° C and Infill Type Cross.

Isparta-İslamköy Örneğinde Arazi Toplulaştırma Çalışmalarının Mekansal Olarak Değerlendirilmesi

Bu çalışmada, Türkiye’de Tarım Reformu Genel Müdürlüğü tarafından yürütülen arazi toplulaştırma çalışmalarının ekolojik temele dayanan planlama yaklaşımı ile gerçekleştirilmesi; alan kullanım seçeneklerini bütünleştirilmesi; ekosistemlerin doğal yapısını bozmadan insanoğlunun yaşamsal faaliyetlerini yürütebilmesi ile optimal alan kullanımlarının belirlenmesine, katkı sağlanması amaçlanmıştır. Çalışma kapsamında, Isparta İslamköy ve yakın çevresinin doğal yapısı, mevcut alan kullanımları ve sosyo-ekonomik yapısı ortaya çıkarılmış; tarım, orman, çayır-mera, rekreasyon, yerleşim ve sanayi kullanım türleri için uygun alan kullanımları belirlenmeye çalışılmıştır. Uygunluk analizinin gerçekleştirilmesinde coğrafi bilgi sistemleri (CBS) ve çok kriterli analiz metodu kullanılmıştır. CBS aracılığı ile uygunluk kriterleri, değerleri ve katsayıları sorgulanarak her alan kullanım türü için uygunluk haritaları hazırlanmış, elde edilen uygunluk haritaları birleştirilerek en ideal alan kullanım haritası oluşturulmuştur. Sonuç olarak, İslamköy idari sınırları içerisinde mevcut alan kullanımları, çevre düzeni planı ve en uygun alan kullanım haritası karşılaştırılmış, köy gelişim alanları tespit edilerek blok planı modeli önerilmiştir.

Development and testing of a composite system for bridge health monitoring utilising computer vision and deep learning

Globally road transport networks are subjected to continuous levels of stress from increasing loading and environmental effects. As the most popular mean of transport in the UK the condition of this civil infrastructure is a key indicator of economic growth and productivity. Structural Health Monitoring (SHM) systems can provide a valuable insight to the true condition of our aging infrastructure. In particular, monitoring of the displacement of a bridge structure under live loading can provide an accurate descriptor of bridge condition. In the past B-WIM systems have been used to collect traffic data and hence provide an indicator of bridge condition, however the use of such systems can be restricted by bridge type, assess issues and cost limitations. This research provides a non-contact low cost AI based solution for vehicle classification and associated bridge displacement using computer vision methods. Convolutional neural networks (CNNs) have been adapted to develop the QUBYOLO vehicle classification method from recorded traffic images. This vehicle classification was then accurately related to the corresponding bridge response obtained under live loading using non-contact methods. The successful identification of multiple vehicle types during field testing has shown that QUBYOLO is suitable for the fine-grained vehicle classification required to identify applied load to a bridge structure. The process of displacement analysis and vehicle classification for the purposes of load identification which was used in this research adds to the body of knowledge on the monitoring of existing bridge structures, particularly long span bridges, and establishes the significant potential of computer vision and Deep Learning to provide dependable results on the real response of our infrastructure to existing and potential increased loading.

A Simple Conjugate Gradient Type Method for Solving Large-scale Systems of Nonlinear Equations

Abstract Quasi Newton’s method is among the most promising algorithm for solving systems of nonlinear equations. In this family, Broyden’s method update is the famous. This paper presents a simple conjugate gradient (CG) method for solving large-scale systems of nonlinear equations via memoryless Broyden’s approach. The attractive attribute of this method is due to its low memory requirements, global convergence properties and simple implementation. Under suitable conditions, the proposed method converges globally. Numerical performance of the proposed method are compared with the well-known conjugate gradients (CG) methods using benchmarks problems. The report demonstrate that the proposed method is reliable, efficient and competitive.

Prediction of Anthocyanin Content in Three Types of Blueberry Pomace by Near-Infrared Spectroscopy

Prediction of Anthocyanin Content in Three Types of Blueberry Pomace by Near-Infrared Spectroscopy

O que a Ciência Política (não) tem a Dizer sobre o Neogolpismo Latino-Americano?

What has been the reaction of Latin American Political Science, and especially of Brazilian Political Science, to the processes of institutional ruptures of a new type suffered by several countries in the region in the last decade? Or, more concretely: how has the discipline been positioning itself against what happened in Honduras in 2009, in Paraguay in 2012, and in Brazil in 2016? What is the centrality of this theme in the research agenda of the political scientists of our countries? We seek to answer these questions by analyzing the texts published in the main journals of the area, as well as examining the articles presented at the Congresses of the Brazilian Association of Political Science (ABCP) and the Congresses of the Latin American Association of Political Science (ALACIP), looking for selected terms that are related to the theme. We start from the assumption that, faced with a new phenomenon that calls into question the survival of Latin American democracies, Political Science, always concerned precisely with the democratic question, should give the subject the prominence it deserves, thus putting it at the top of their academic and political concerns. The article confirms the hypothesis that the theme is almost absent in the production of Latin American political science.

Derechos de autor y buenas prácticas en las publicaciones científicas

Las publicaciones científicas constituyen un importante indicador de la trayectoria laboral de un investigador, resultante de intereses, restricciones y de diversas negociaciones. Un lugar en que se manifiestan muchos de estos elementos es la configuración de las autorías del trabajo. Esto suele ser motivo de tensiones cuando, por ejemplo, en la lista de autores de un trabajo se excluye a alguien que generó determinado tipo de información o contenido; así como cuando se incorporan autores por devolución de gentilezas que nada aportaron a dicho contenido. Como investigadoras y editoras de la Revista Argentina de Antropología Biológica, basándonos en nuestra experiencia y en comentarios recibidos de algunos colegas en el ejercicio de actividades de investigación, entendemos que es necesario aportar elementos de reflexión sobre este tema. Los objetivos de este trabajo son los de a) visibilizar la problemática sobre el reconocimiento de autorías en las publicaciones y b) aportar algunas directrices para garantizar el respeto a los derechos de autor.

Qualidade das juntas coladas de madeira de cinco espécies de Eucalyptus com adesivos acetato de polivinila e resorcina-formaldeído

O objetivo deste trabalho foi avaliar o potencial das madeiras de Eucalyptus benthamii, Eucalyptus dunnii, Eucalyptus grandis, Eucalyptus saligna e Eucalyptus urophylla, para produção de painéis colados lateralmente (EGP) e madeira laminada colada (MLC). As propriedades físicas e químicas das madeiras foram determinadas com base nas normas COPANT 461/459:1972 e TAPPI 204/252:2002. Foram confeccionadas juntas coladas com adesivo acetato de polivinila (PVA), com gramaturas de 150 g m-2 e 200 g m-2, e resorcina-formaldeído (RF), com 200 g m-2 e 300 g m-2. A qualidade de colagem foi avaliada por meio de ensaios de cisalhamento, com base na norma EN 13354:2008. Todas as espécies apresentaram densidade básica de média a baixa e anisotropia de contração de média a alta. O teor de extrativos totais e pH estão dentro da faixa referenciada na literatura. As avaliações dos resultados com base nos requisitos da norma EN 15353:2008 para 5º percentil inferior indicaram que as espécies E. benthamii, E. dunnii, E. grandis e E. saligna, apresentam potencial para produção de painéis EGP com adesivo PVA, para o uso interno, e externo com cobertura. Para a colagem com adesivo RF, o E. dunni apresentou melhores resultados, sendo indicativo do seu bom potencial para a produção de madeira laminada colada, visando aplicações estruturais em ambientes interno úmido e externo. Para os dois tipos de adesivos o aumento na gramatura não afetou os resultados de cisalhamento das juntas coladas.

О перспективах Дальнего Востока после саммита АТЭС-2012

<span>Проведен анализ последствий прошедшего восемь лет назад саммита АТЭС во Владивостоке: как принималось решение о проведении мероприятия, какие объекты построены, как это отразилось на социально-экономической ситуации в городе и Приморском крае, какие инвестиционные проекты после саммита реализуются на территории Дальнего Востока, и насколько предпринятые усилия повлияли на отток населения. Утверждается, что сырьевая направленность экономической специализации является главной причиной сохраняющейся высокой миграции, тогда как курс на новую индустриализацию и инновационное развитие может принципиально изменить ситуацию. Предлагается набор мер, которые смогут обеспечить переход к новому типу хозяйствования: во взаимоотношениях власти и потенциальных резидентов территорий опережающего развития и свободного порта Владивосток; в организации пространства и формировании агломерации нового типа; в трансформации роли и содержания работы Восточного экономического форума и уточнении миссии федерального университета.</span>