Types Of Transfusion Reactions Research Articles

Rational Use Of Blood And Blood Components

The basis for appropriate use of blood and tissue homographs is founded on an understanding of the risks, benefits, and alternatives to their use. In this article, the issues that need to be considered when the clinician obtains informed consent are discussed. Infectious risks of transfusion and tissue homographs are reviewed in historical context. Various types of transfusion reactions, their frequency, cause, and treatment are detailed. Lastly, current guidelines for the appropriate use of blood components and alternatives to homologous transfusion are reviewed.

Further studies on the effect of adenine in blood preservation.

Clinical and experimental studies on the effect of adenine supplementation to ACD blood are reported. The frequency and type of transfusion reactions in 5,595 transfusions of ACD‐adenine blood (storage time 0–35 days) was the same as in 4,519 transfusions of ACD blood (storage time 0–21 days). There was no change in the plasma haptoglobin level in 10 recipients during and after transfusion of 29 to 35 day old ACD‐adenine blood.The relation between posttransfusion viability, in vitro hemolysis, erythrocyte ATP content and duration of storage were studied. Supplementation with adenine increased the posttransfusion viability and the erythrocyte ATP content; these effects were noticeable after two weeks of storage. A negative correlation was found with respect to posttransfusion viability and the concentration of total lipids in the medium. A significant covariation between the concentrations of the three nucleotides ATP, ADP and AMP was found. This indicates that erythrocyte adenylate kinase dominates in the regulation of the relative concentrations of these nucleotides.

IMPROVEMENT IN BLOOD TRANSFUSION SERVICE

An important method of approach to the study of the value of preserved blood is an analysis of the results of transfusion of such blood. Just as some questions which arise as to the limitations of bank blood are answered by inquiry into the changes which occur in various components of blood when preserved, other, equally important questions, such as the effect of age of blood on the incidence and type of transfusion reactions, can be answered only by accurate recording of the results obtained from a long series of transfusions of bank blood. It is from this standpoint primarily that a statistical analysis of 3,077 consecutive transfusions of bank blood at the Cincinnati General Hospital becomes of interest. Numerous collateral points of interest which pertain to the practical operation of the service are also revealed by this study. These are of value to any one planning a similar organization