Type Of Thyroid Disease Research Articles

Effect of estrus and estrogen on thyroid uptake of I131 in rats.

HYPERTHYROIDISM, nodular goiter and other types of thyroid disease are more frequently found in women than in men. Goiter, also, often becomes strikingly manifest during puberty, pregnancy and the menopause. This apparent relationship between ovarian function and thyroid pathology has been studied by many investigators. Unfortunately the results have been conflicting. Some have reported that ovarian hormones depress thyroid function (Franck, 1937; Gardner, 1949; Heyl et al., 1934; Karp and Kostkiewicz, 1934; Kreitmar and Sieckman, 1939; Miiller and Aeppli, 1949); others, that ovarian hormones increase thyroid activity (Andersen, 1935; Chouke et al., 1935; De Amilbia et al., 1936; Desclin and Ermans, 1951); and still others have observed no distinct influence upon thyroid structure and physiology (Arnold et al., 1938; Paschkis et al. 1948). A few reports have indicated that estrogens both stimulate and depress thyroid function, depending upon the dose and period of administration (Freudenberger and Clausen...

ADENOMA OF THE LINGUAL THYROID

Since Hunt's first report of a lingual thyroid in 1866, 1 numerous papers have appeared in the literature describing this condition. While it is by no means a medical curiosity, since it occurs in 1 out of 2,500 to 4,000 instances of all types of thyroid disease, 2 the experiences of any one physician are usually so limited that when such a condition presents itself he must consult the literature in order to manage properly the case at hand. This report was stimulated by the fact that we recently had a patient with most unusual symptoms, and the diagnosis was made only after the operation was performed. REPORT OF A CASE A 49-year-old white woman was admitted to the hospital with the complaint of a mass in the right submaxillary-submental triangle of the neck for nine months prior to admission. The mass was first noticed by her dentist during the

The current treatment of hyperthyroidism.

OF the recent developments in the field of thyroid research two have proved to be of far-reaching clinical significance: 1) the discovery that the function of the thyroid gland can be suppressed by goitrogenic drugs, notably thiouracil and related compounds, and 2) the demonstration of the value of radioiodine as a tool for study of thyroid function as well as a therapeutic agent in the treatment of some types of thyroid disease. By opening new approaches to thyroid investigation, these agents have been responsible for rapid and sound advances in our knowledge of the physiology of the thyroid gland, and both have contributed greatly to the effectiveness of the treatment of hyperthyroidism. However, it is evident that these advances have not provided the final solution to the problem of goiter, nor has effectiveness of treatment yet reached the stage whereby established methods of treatment can now be discarded. It seems obvious that the present status of surgical treatment of hyperthyroidism cannot be acc...

END-RESULTS OF OPERATION ON THE THYROID GLAND

Surgical intervention is considered the proper treatment for the various types of thyroid disease; still one must admit that there is much to be desired in this field. It is difficult to evaluate completely the results obtained, even under the best conditions, owing to the numerous variable factors which may be encountered in procuring the data. Crile 1 reported from the Cleveland Clinic that 86.3 per cent of more than 12,000 patients treated for hyperthyroidism were able to resume their former occupation in less than a year after the operation. Moore 2 reported cures in 82.7 per cent of persons with exophthalmic goiter, in 88.9 per cent of those with adenomatous goiter and in 51 per cent of those with secondary exophthalmic goiter (toxic adenoma). What constitutes a cure he did not state, and therefore it is difficult to know on what basis the cures may be evaluated. From the

BLOOD CHOLESTEROL IN THYROID DISEASE

In part I of this study, the blood cholesterol values found in different types of thyroid disease were presented. This report deals with the effect of preoperative and operative treatment. The cases dealt with herein comprise those in which postoperative myxedema did not occur. Cases in which myxedema did occur will be dealt with in part III of this study. On the other hand, cases with postoperative low metabolic rates but without clinical evidences of low thyroid function are included. EFFECT OF PREOPERATIVE AND OPERATIVE TREATMENT Effect of Preoperative Treatment in Exophthalmic Goiter. —It was shown in part I that patients who had received iodine before coming under observation had a higher average value for cholesterol and a lower average basal metabolic rate than those who had not. Preoperative preparation, which consisted mainly of the administration of 30 minims (1.9 cc.) of compound solution of iodine daily, an adequate amount

THE OCCURRENCE OF YEASTS IN PATIENTS WITH THYROID DISEASE

The types of thyroid disease indicated by the title of this paper are exophthalmic goiter, colloid goiter, adenomata, and myxedema. For four and one-half years I have been investigating patients with lesions of the skin due to fungi. As there is no known method of permanently curing the condition, it seemed obvious that there must be some continued source of contamination. The gastric contents and stools were cultured to ascertain if the intestinal tract was the focus of continual contamination. These cultures were positive on either the first or second trial in every instance. The gastric contents yielded more abundant cultures in many instances than the stools. As many of the patients had annoying sensations in the mouth, the saliva was cultured. The saliva was positive for yeasts in all instances where the cutaneous condition was at all marked. When the saliva was negative, the gastric contents or stools, or both, were positive. The saliva cultures offer a ready method of investigation. The organisms i...