Event Abstract Back to Event Crossmodal neuroimaging of object-related integration in subcortical structures of the human brain M. J. Naumer1*, Y. Yalachkov1, A. Polony1, L. Ratz1, G. Hein2, O. Doehrmann1, G. Van De Ven V3 and J. Kaiser1 1 Johann Wolfgang Goethe-University, Germany 2 University of Zürich, Switzerland 3 Maastricht University, Netherlands Based on invasive electrophysiology it has been recently hypothesized that in addition to the superior colliculus (SC) further subcortical structures (i.e. the cerebellum, the thalamus, and the basal ganglia) might play a critical role in multisensory integration. So far, however, non-invasive evidence in humans for such subcortical involvement is almost completely lacking. In a series of fMRI experiments, we first searched for visuo-tactile (VT) integration regions employing the so-called Max-criterion (VT>max[V, T]), while we manipulated the side of active touch (left vs. right hand) and the degree of VT (orientation or identity) congruency. The results showed robust, bilateral VT integration effects in the lateral cerebellum that were substantially more pronounced during stimulation of the ipsilateral as compared to the contralateral hand and independent of VT congruency or the type of stimulus material (i.e familiar natural versus unfamiliar artificial). Additional tests for audio-visuo-tactile (AVT) integration in this region showed no significant effects indicating that the role of the lateral cerebellum might be specific to VT integration. In complementary analyses of these fMRI data sets we employed spatial independent component analysis (sICA). SICA is a multivariate, data-driven analysis technique that decomposes fMRI data into spatially independent components, which can be interpreted as functional connectivity maps. Selection of components of interest for further analysis was done by visual inspection. Among the task-related independent components (ICs) of the AVT experiment three apparently unisensory ICs were most robustly detected. Each of these ICs suggested a network of functionally connected cortical and subcortical regions processing auditory, visual, and somatosensory-motor information, respectively. Combining these IC-maps provided a surprisingly clear parcellation of the sensorimotor thalamus in its medial geniculate (MGN), lateral geniculate (LGN), and ventral posterior (VPN) nuclei. The same subjects also participated in two independent audio-visual (AV) and VT experiments. These data enabled explicit testing of the hypothesized thalamic involvement in multisensory integration. Our results indicate AV integration effects (Max-criterion: AV>max[A, V]) in bilateral MGN (but not LGN) and similar VT integration effects in both LGN and VPN. Interestingly, these latter effects were only detectable when our subjects grasped the objects with their non-dominant (left) hand, which suggests that VT integration effects in distinct nuclei of the human thalamus are most pronounced when unimodal (haptic) stimulation is least effective, in accordance with the inverse-effectiveness rule. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Turkey, 1 Sep - 5 Sep, 2008. Presentation Type: Oral Presentation Topic: Symposium 3: Neural basis of multisensory integration Citation: Naumer MJ, Yalachkov Y, Polony A, Ratz L, Hein G, Doehrmann O, Van De Ven V G and Kaiser J (2008). Crossmodal neuroimaging of object-related integration in subcortical structures of the human brain. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.020 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Nov 2008; Published Online: 27 Nov 2008. * Correspondence: M. J Naumer, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany, M.J.Naumer@med.uni-frankfurt.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers M. J Naumer Y. Yalachkov A. Polony L. Ratz G. Hein O. Doehrmann G. Van De Ven V J. Kaiser Google M. J Naumer Y. Yalachkov A. Polony L. Ratz G. Hein O. Doehrmann G. Van De Ven V J. Kaiser Google Scholar M. J Naumer Y. Yalachkov A. Polony L. Ratz G. Hein O. Doehrmann G. Van De Ven V J. Kaiser PubMed M. J Naumer Y. Yalachkov A. Polony L. Ratz G. Hein O. Doehrmann G. Van De Ven V J. Kaiser Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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