Skin Type Research Articles

Advancements in hyperpigmentation management: exploring conventional methods, phytoconstituents, novel approaches, and instrumental techniques

ABSTRACT Hyperpigmentation is a common dermatological condition characterized by the darkening of patches of skin compared to the surrounding areas. It can occur in individuals of all skin types and ethnicities, and is caused by an overproduction or accumulation of melanin, the pigment responsible for the color of our skin, hair, and eyes. This comprehensive overview aims to delve into the various types, causes, risk factors, clinical manifestations, diagnosis, and treatment options for hyperpigmentation. Additionally, it explores the global and national prevalence of hyperpigmentation, its etiology, pathophysiology and diagnosis and treatment strategies. Furthermore, examines the formulations and dosage forms used to treat hyperpigmentation, including their side effects. It also discusses combination drugs and their associated side effects, as well as novel drug delivery systems and nanocarriers employed in the treatment of hyperpigmentation, providing insight into future prospects in this field.

Development of optical microneedle–lens array for photodynamic therapy

Recently, photodynamic therapy (PDT) which involves a photosensitizer (PS), a special drug activated by light, and light irradiation has been widely used in treating various skin diseases such as port-wine stain as well as cancers such as melanoma and non-melanoma skin cancers. PDT comprises two general steps: the introduction of PS into the body or a specific spot to be treated, and the irradiation process using a light source with a specific wavelength to excite the PS. Although PDT is gaining great attention owing to its potential as a targeted approach in the treatment of skin cancers, several limitations still exist for practical use. One of the biggest challenges is the limited penetration of light owing to scattering, reflection, and absorption of light inside the skin layers. In addition, accidental light exposure of the target area causes additional cellular damage, which causes unexpected complications. To solve these issues, we introduced an optical microneedle–lens array (OMLA) to improve the efficiency and safety of PDT treatment. We designed and fabricated a novel optical microneedle–lens array with controlled dimensions to optimize light transmission. In addition, PS was coated uniformly over the tips of the OMLA using the dip coating method. Finally, we confirmed that the PS coated on the OMLA was released into the target area and subsequently generated radical oxygen by light irradiation. We expect that our proposed OMLA for PDT treatment can realize a new light-transmission platform optimized for PDT with targeting various types of skin cancers.Graphical abstract

Evaluating mobile apps for sun protection: content analysis and user preferences in a two-part study

ABSTRACT Background: Sunburn and intermittent sun exposure elevate melanoma skin cancer risk. Sun protection behaviours, including limiting sun exposure, seeking shade, wearing protective gear, and using sunscreen, help mitigate excessive sun exposure. Smartphone apps present a promising platform to enhance these behaviours. Objective: Part 1 aimed to analyse and evaluate the content of mobile apps that encourage sun protection behaviours, focusing on features, and behaviour change techniques (BCTs). Part 2 explored user preferences and usability post-initial use and two weeks later. Results: Part 1 identified 1294 apps; after applying exclusion criteria, 87 apps were downloaded, with 48 included for analysis. The apps presented opportunities for enhancement in their theoretical and evidence basis, and visualisations use (e.g. UV-index). The apps mapped across a total of 12 BCTs (M = 1.71, SD = 1.07; range = 0–5). The most frequently identified BCTs were ‘instruction on how to perform behaviour’ (65%), ‘information about health consequences’ (29%), and ‘prompts/cues’ (27%). In Part 2, participants favoured features supporting knowledge and ease of use. Participants expressed a preference for apps that are free of paid features, advertisements, and external purchases. Tailored advice (e.g. location, skin type) was deemed crucial, particularly for initial exposure. Proactive features integrating behavioural, personal, and contextual information for adaptive and just-in-time sun protection advice were seen as essential for sustaining engagement. Conclusions: Sun protection apps emphasizing knowledge, ease of use, tailored advice, and proactive features are likely to encourage sustained engagement. Suggestions for optimising current and future sun protection apps are provided.

Integrating Explainable AI for Skin Lesion Classifications: A Systematic Literature Review

Skin cancer, particularly melanoma, poses a significant global health challenge due to its prevalence and mortality rate. Early detection is critical to improving outcomes, as advanced cases become increasingly difficult to treat. The advent of Artificial Intelligence (AI) and Explainable AI (XAI) techniques has revolutionized dermatological diagnostics by offering accurate and interpretable solutions. This systematic review investigates the integration of XAI in skin lesion classification, analyzing 22 recent studies published between 2019 and 2023. The studies encompass diverse approaches, including deep learning models like CNNs, ResNet, DenseNet, and MobileNet, as well as explainability techniques such as Grad-CAM, SHAP, and saliency maps. Results highlight significant advancements in accuracy and interpretability, with some models achieving over 99% accuracy on datasets like ISIC 2018 and HAM10000. However, challenges persist, including dataset imbalances, limited diversity in patient metadata, and generalizability across different skin types and imaging conditions. XAI methods, by visualizing model decision pathways, enhance transparency, fostering trust among clinicians and enabling seamless AI integration into clinical practice. This review underscores the potential of combining state-of-the-art AI models with explainable frameworks to address the complexities of skin lesion diagnostics. It advocates for future research to prioritize diverse, metadata-rich datasets, innovative optimization techniques, and robust architectures to develop reliable, interpretable diagnostic tools. By bridging the gap between advanced AI and user understanding, this work contributes to the creation of clinically applicable, trustable AI-driven healthcare solutions.

Lip Augmentation in Patients with Fitzpatrick Skin Type V and VI: Use of a Validated Lip Fullness Scale and Determining Preinjection Lip Size Preference and Postinjection Patient Satisfaction.

Background: There is limited literature assessing cosmetic lip size preferences in darker-skinned individuals. Objective: To measure preinjection lip augmentation preferences and postinjection satisfaction using the revised Lip Fullness Scale (LFS) in female participants with Fitzpatrick Skin Type V and VI. Methods: Females, aged 21 and over, with Fitzpatrick Skin Type V and VI desiring lip augmentation were recruited from a high-volume outpatient facial plastic surgery clinic. The LFS scale was administered pre- and postinjection. FACE-Q scales which measure patient reported outcomes for facial cosmetic procedures were administered postinjection. Results: Twenty-two female subjects participated in the study. The average age was 33.2 years (SD = 8.1). Fourteen participants (14) were Fitzpatrick V and eight (8) were Fitzpatrick VI. The average preinjection self-assessment LFS was 3.5. The final average postinjection self-assessment LFS score was 4.3. The increase in final postinjection LFS scores was found to be statistically significant with a p-value <0.001 when compared with preinjection LFS scores. Patients reported high satisfaction on postinjection FACE-Q. Conclusion: Patients with darker skin may prefer marked to very marked lip fullness, and physicians should be conscientious in understanding patients' individual perspectives and aesthetic goals.[Box: see text].

UJI ANALISIS KUALITATIF DAN KUANTITATIF KADAR VITAMIN C PADA SEDIAAN KOSMETIK LOTION YANG BEREDAR DI KAB. MAROS DENGAN METODE SPEKTROFOTOMETER Uv-Vis

Cosmetics are an inseparable part of women's lives in particular and are used every day. Lotions are widely used to moisturize the skin and to brighten the skin. Lotion can be used for all skin types for teenagers aged 15 years and over. Vitamin C has various benefits, including as an antioxidant against pollution, sun exposure, brightening the skin, delaying the effects of aging, and increasing collagen formation which makes the skin supple, smooth and bright. The aim of the research was to determine the vitamin C content in cosmetic lotions according to the standards/labels circulating in the Maros district. The research was carried out using qualitative analysis methods in the pharmaceutical chemistry analysis laboratory of STIKes Salewangang Maros where the samples were lotion cosmetic products containing vitamin C at kab. Maros as stated on the product packaging/label and analyzed using a Uv-Vis spectrophotometer. The results of the research obtained showed that all lotion cosmetic preparations contained vitamin C with different percentage levels for each concentration, where lotion samples that did not have a distribution permit obtained high levels of Vitamin C, while lotions that had a distribution permit showed high levels of Vitamin C. not excessive, so it is safe to use for a long time.

Efficacy of the 595nm pulsed dye laser in the treatment of hemangiomas in Vietnamese patients.

Hemangiomas are common benign vascular tumors that often present in childhood. The 595nm pulsed dye laser (PDL) is now being widely used to treat vascular skin lesions. This case series was performed to review the therapeutic efficacy and safety of PDL in the treatment of hemangiomas among Vietnamese patients. A total of 43 Vietnamese patients (79.1% females), mean age was 8.83 years old (2 months - 54 years old), with a clinical diagnosis of hemangioma, were treated with the PDL over 2 years. Treatments were performed every 4 weeks. Hemangioma lesions that occur on the head and the neck are seen in 65.1%, 67.4% of superficial, and 32.6% of mixed hemangioma subtypes. The mean treatment is 5.3 times. Excellent-good results were achieved in 86.1%, average results in 11.6%. No permanent side effects during the treatments were observed. Treatment of hemangiomas using the 595nm PDL is an effective and safe method in the skin types of Vietnamese patients. The effect does require several treatment sessions.

Non-Ablative Fractional 1940-nm Diode Laser for Skin Resurfacing and Treatment of Benign Pigmented Lesions.

The non-ablative 1940-nm laser induces controlled thermal damage at superficial depths without ablating the epidermis. We evaluated a new 1940-nm fractional diode laser for improving pigmentation and skin texture. Participants with mild to severe benign pigmented lesions received up to three laser treatments. Blinded evaluation of randomized pretreatment versus 1-month posttreatment photos was conducted by three independent dermatologists to identify the correct posttreatment image and assess pigmentation on a 5-point scale (0 = 0% improvement, 4 = 75%-100% improvement) and skin texture improvement. Fifty-four subjects (50 females; Fitzpatrick skin types I-IV) with pigmented lesions on the face or body underwent a total of 172 treatments. Blinded evaluation of 45 photography sets resulted in a 91% success rate of correct identification of posttreatment photos with a mean pigmentation improvement score of 2.0 (p < 0.05) and improvement in skin texture for 62% of treated areas. Mild to moderate edema (70%) and erythema (88%) were observed immediately posttreatment. Trace melasma recurrence in three subjects and one case of mild rash resolved during the study. Non-ablative fractional 1940-nm diode laser skin resurfacing is safe and effective at improving overall skin quality and treating pigmentation after 2-3 treatments. Long-term follow-up of clinical outcome is warranted.

Comparative efficacy and safety of the novel Picosecond Alexandrite Laser and the traditional combined Q-switched and long-pulse Nd: YAG lasers in melasma treatment: a randomized evaluator-blinded trial

Melasma significantly impacts life quality, and while various laser therapies show promise, rigorous comparative studies, especially between the novel Picosecond Alexandrite Laser (PSAL) and the traditional combined modality of Q-switched and Long-pulse Nd: YAG Lasers (QLNYL), are notably lacking. This study aims to fill this gap by evaluating the efficacy and safety of these modalities, providing insights into their comparative advantages for clinical practice. In a prospective, evaluator-blinded study, 40 participants with Fitzpatrick Skin Types (FST) III and IV underwent three treatment sessions at four-week intervals with either PSAL or QLNYL. Efficacy was primarily assessed by changes in Melasma Area and Severity Index (MASI) scores at baseline, 4, 8, 12, and 24 weeks, along with patient satisfaction evaluations at the 12- and 24-week marks, and safety assessments conducted throughout the study. Both groups experienced significant reductions in MASI scores post-treatment. Overall, the improvement in MASI scores in the QLNYL group significantly surpassed that in the PSAL group (P = 0.010). Patient satisfaction was comparably high between groups, and no significant differences were noted in safety profiles. The PSAL group showed a slightly higher incidence of adverse reactions (not significant) and significantly higher pain scores (P = 0.018). Recurrence rates at the 24-week follow-up were 10.5% for PSAL and 0% for QLNYL, with no significant difference. Both PSAL and QLNYL proved effective in treating melasma, with the traditional combined modality of QLNYL demonstrating superior efficacy in FST III-IV. Safety profiles were similar comparable.

A Novel Ablative Fractional 2,910-nm Erbium-Doped Fluoride Glass Fiber Laser for the Treatment of Photoaging in Fitzpatrick Skin Type IV.

A Novel Ablative Fractional 2,910-nm Erbium-Doped Fluoride Glass Fiber Laser for the Treatment of Photoaging in Fitzpatrick Skin Type IV.

Prevalence and pattern of skin disorders among children living in orphanages in Fayoum and Giza governorates, Egypt

BackgroundChildhood is a crucial period that shapes a person’s growth and development. For orphans, a lack of familial support affects their upbringing, making orphanages crucial for care. Children living in orphanage centers are vulnerable to several conditions, including dermatological disorders, due to factors such as malnutrition, overcrowding, and poor hygiene. The current study was carried to determine the prevalence and patterns of skin disorders among orphan children in Egypt, and to identify associated risk factors among orphans in Egypt.MethodsA cross-sectional study was conducted among 415 children aged 1–18 years living in orphanage centers in Fayoum and Giza governorates, Egypt.ResultsAmong the children, 77.1% had at least one skin disorder, with noninfectious conditions being more prevalent than infectious conditions (67.4 vs. 24.3%). The most common noninfectious conditions were dermatitis/eczema, pigmentary disorders, skin appendage disorders, and psycho-cutaneous issues. Fungal infections were the most common infectious condition. There was a significant relationship between hygiene and the type of skin disorder.ConclusionThe prevalence of skin diseases in orphanages in Egypt is relatively high and is dominated by noninfectious skin diseases, and the prevalence of psycho-cutaneous disorders is high among these children. Comprehensive care strategies focusing on improving hygiene and emotional support and preventing abuse are essential for reducing the incidence of skin disorders and enhancing the overall health of orphaned children.

The lipocalin saga: Insights into its role in cancer-associated cachexia.

Cancer-associated cachexia (CAC) is a debilitating condition, observed in patients with advanced stages of cancer. It is marked by ongoing weight loss, weakness, and nutritional impairment. Lower tolerance of chemotherapeutic agents and radiation therapy makes it difficult to treat CAC. Anorexia is a significant contributor to worsening CAC. Anorexia can be found in the early or advanced stages of cancer. Anorexia in cancer patients arises from a confluence of factors. Tumor-related inflammatory cytokines can directly impact the gastrointestinal tract, leading to dysphagia and compromised gut function. Additionally, increased serotonin and hormonal disruptions lead to early satiety, suppressing appetite. Due to the complexities in the pathogenesis of the disease, identifying druggable targets is a challenge. Research is ongoing to identify novel targets for the treatment of this condition. Recent research suggests a potential link between elevated levels of Lipocalin 2 (LCN2) and cachexia in cancer patients. LCN2, a glycoprotein primarily released by neutrophils, is implicated in numerous illnesses, including skin disorders, cancer, atherosclerosis, and type 2 diabetes. LCN2 suppresses hunger by binding to the melanocortin-4 receptors. Several in vitro, in vivo, and clinical studies indicate the association between LCN2 levels and appetite suppression. Further research should be explored emphasizing the significance of well-crafted clinical trials to confirm LCN2's usefulness as a therapeutic target and its ability to help cancer patients who are suffering from the fatal hallmark of cachexia. This review explores LCN2's function in the multifaceted dynamics of CAC and anorexia.

Herbal Facial Toner: A Review

Herbal facial toners have gained popularity for their natural and soothing properties, offering an effective solution for skin care. These toners, derived from plant-based ingredients, help to refresh, hydrate, and balance the skin's pH while providing essential nutrients. Rich in antioxidants, vitamins, and minerals, herbal toners are gentle on the skin, making them suitable for all skin types, including sensitive skin. By incorporating botanicals such as aloe vera, witch hazel, rose water, and chamomile, these toners not only cleanse the skin but also promote healing and calm irritation. Their natural formulation ensures minimal side effects, unlike harsh chemical-based alternatives. Herbal facial toners play a vital role in maintaining healthy, radiant skin while offering a holistic approach to beauty care. Keywords: Herbal facial toner, Plant based ingredients, Anti-inflammatory, Eco-friendly

Monte Carlo Simulation of the Effect of Melanin Concentration on Light-Tissue Interactions in Reflectance Pulse Oximetry.

Over the past ten years, there has been an increasing demand for reliable consumer wearables as users are inclined to monitor their health and fitness metrics in real-time, especially since the COVID-19 pandemic. Reflectance pulse oximeters in fitness trackers and smartwatches provide convenient, non-invasive SpO2 measurements but face challenges in achieving medical-grade accuracy, particularly due to difficulties in capturing physiological signals, which may be affected by skin pigmentation. Hence, this study sets out to investigate the influence of skin pigmentation, particularly in individuals with darker skin, on the accuracy and reliability of SpO2 measurement in consumer wearables that utilise reflectance pulse oximeters. A Monte Carlo model is developed to assess the effect on simulated reflectance pulse oximetry measurements across light, moderate, and dark skin types for oxygen saturation levels between 70 and 100%. The results indicate that a one-algorithm-fits-all calibration approach may be insufficient, and root mean square errors (RMSEs) of at least 0.3956%, 0.9132%, and 8.4111% for light, moderate, and dark skin are observed when compared to transmittance calibration algorithms. Further research is required to validate these findings and improve the performance of reflectance pulse oximeters in real-world applications, particularly in the context of consumer wearables.

Impact of particulate matter exposure on melanoma risk: A multicentre case-control study.

The relationship between particulate matter (PM) exposure and melanoma risk remains largely unexplored. This study aims to investigate the association between PM10 and PM2.5 long-term exposure and melanoma risk. Case-control study involving 2575 participants, comprising 1473 melanoma patients and 1102 healthy controls attending Departments of Dermatology of University Hospital in North and Central Italy. Demographic data, smoking status, history of sunburns and skin type were collected. PM10 and PM2.5 exposure levels were estimated for each participant's residential address using a Bayesian hierarchical model, providing daily concentrations at a 1 km2 spatial resolution from 2013 to 2021. Logistic regression analyses were performed to evaluate the association between PM exposure and melanoma risk, adjusting for potential confounders. Melanoma patients and controls were 52% males and had a mean age of 63.89 and 61.66 years, respectively. The majority of melanoma patients had Fitzpatrick phototypes 2 (59%) and 3 (36%). There were no significant differences in the geographical distribution of cases and controls based on ZIP codes (p = 0.894). The average melanoma Breslow thickness was 1.01 mm, with 68.15% of cases diagnosed at stage 0 and IA. The multivariate logistic regression revealed a protective effect for higher PM10 (OR = 0.89, 95%CI: 0.86-0.92, p < 0.001) and PM2.5 levels (OR = 0.72, 95%CI: 0.68-0.76, p < 0.001). Darker skin phototypes (Fitzpatrick 4) and cigarette smoking were also associated with a reduced risk of melanoma. Higher levels of PM10 and PM2.5 may have a protective effect against melanoma, potentially due to the reduction in ultraviolet radiation exposure. Further research to understand the complex interactions between environmental factors and melanoma risk are needed.

The Role of Fractional Radiofrequency in Long-term Acne Remission and Reduction of Acne Scar Load.

Acne is an inflammatory skin disease afflicting the majority of the world's population at some point in their lifetime, and is seen to be chronic in about 50% of cases. Acne leads to significant social withdrawal, depression, and disfiguring scars in many cases. Available treatments are characterized by high rates of relapse, dangerous side effects, and social stigma, which often leads to poor patient compliance and treatment failure. The aim of this article was to discuss and share the authors' experiences utilizing fractional radiofrequency (RF) (Morpheus8; InMode Ltd., Lake Forest, CA) in the treatment of both active acne and acne scars. A retrospective review was conducted comparing 3 treatment modalities. In total, 356 patients received acne scar treatments. The cohort comprised a high-dose isotretinoin topical therapy series (n = 128, 36%), a 6-session ablative laser series (n = 89, 25%), and a 3-session fractional RF microneedling series (n = 139, 44). Of the patients with extended 3-year follow-up, the relapse rates were: isotretinoin group, 36 of 54 (67%); laser group, 12 of 16 (75%), and fractional RF microneedling group, 7 of 29 (24%). In treating older acne scars, fractional RF microneedling technology has served as an effective tool to tighten skin and fill in atrophic scars when used in conjunction with other techniques. This technology is very effective and very safe for treating all skin types with acne and acne scars.

A comprehensive classification and analysis of oily sensitive facial skin: a cross-sectional study of young Chinese women

Oily sensitive skin is complex and requires accurate identification and personalized care. However, the current classification method relies on subjective assessment. This study aimed to classify skin type and subtype using objective biophysical parameters to investigate differences in skin characteristics across anatomical and morphological regions. This study involved 200 Chinese women aged 17–34 years. Noninvasive capture of biophysical measures and image analysis yielded 104 parameters. Key classification parameters were identified through mechanisms and characteristics, with thresholds set via statistical methods. This study identified the optimal ternary value classification method for dividing skin types into dry, neutral, and oily types based on tertiles of biophysical parameters and, further, into barrier-sensitive, neurosensitive, and inflammatory-sensitive types. Oily sensitive skin shows increased sebum, follicular orifices, redness, dullness, wrinkles, and porphyrins, along with a tendency for oiliness and early acne. Subtypes exhibited specific characteristics: barrier-sensitive skin was rough with a high pH and prone to acne; neurosensitive skin had increased TEWL (Transepidermal Water Loss) and sensitivity; and inflammatory-sensitive skin exhibited a darker tone, with low elasticity and uneven redness. This study established an objective classification system for skin types and subtypes using noninvasive parameters, clarifying the need for care for oily sensitive skin and supporting personalized skincare.

Investigation of corneal topographic and ocular surface parameters in ocular rosacea based on skin subtypes.

To compare the corneal topographic parameters and ocular surface parameters of ocular rosacea (OR) patients across skin subtypes of the disease and healthy controls. This prospective study included 180 eyes of 90 OR patients and 60 eyes of 30 healthy controls. Among the OR patients, 30 had phymatous (60 eyes), 30 had erythematotelangiectatic (60 eyes) and 30 had papulopustular skin types (60 eyes). We measured the mean keratometry (Kmean), maximum keratometry (Kmax), thinnest corneal thickness (TCT), central corneal thickness (CCT) and corneal volume (CV) with a topography device (Sirius, Italy). Additionally, we measured tear-film breakup time (TBUT), Meiboscore and Schirmer's test from all participants. We compared parameters across OR skin groups as well as with controls. Kmean and Kmax were significantly steeper in the OR group compared to controls (p<0.05). We found significant correlations between "Kmean-Kmax", "CV-TCT", "CV-CCT", and "TCT-CCT" in both groups, while significant correlations between "age-Kmean", "age-Kmax", and "Meiboscore-Kmax" were present only in OR patients. When patients were divided into subgroups according to their skin subtypes, the papulopustular and phymatous subgroups had steeper Kmean and Kmax compared to the erythematotelangiectatic and control groups (P<0.05). The papulopustular subgroup had lower CCT, lower TBUT and higher Meiboscore compared to the phymatous, erythematotelangiectatic and control groups but lower TCT compared to controls (P<0.05). In addition, there were significant correlations between "Kmax-CV", "Kmax-TCT", and "Kmax-meiboscore" only in the papulopustular subgroup (P<0.05). It appears that the corneas of OR patients are steeper than those of healthy controls; corneal thinning and abnormalities of ocular surface parameters are more pronounced in papulopustular skin types.

Analysis of the Effect of Skin Pigmentation and Oxygen Saturation on Monte Carlo-Simulated Reflectance Photoplethysmography Signals.

The effect of skin pigmentation on photoplethysmography and, specifically, pulse oximetry has recently received a significant amount of attention amongst researchers, especially since the COVID-19 pandemic. With most computational studies observing overestimation of arterial oxygen saturation (SpO2) in individuals with darker skin, this study seeks to further investigate the root causes of these discrepancies. This study analysed intensity changes from Monte Carlo-simulated reflectance PPG signals across light, moderate, and dark skin types at oxygen saturations of 70% and 100% in MATLAB R2024a. With simulated intensity reflecting PPG amplitude, the results showed that systolic intensity decreased by 3-4% as pigmentation increased at 660 nm. It was also shown that the impact at 940 nm is minimal (<0.2%), indicating that the increased absorption of red light by melanin has a greater effect on the ratio of ratios calculations. These results suggest that in-built adjustments may be required for data collected from red-light sources in pulse oximeters that do not currently have the necessary post-processing algorithms to account for this difference between diverse skin populations.

Efficacy and Safety of 730-nm Picosecond Laser for the Treatment of Acquired Bilateral Nevus of Ota-like Macules.

The effectiveness and safety of 730-nm picosecond laser for treating acquired bilateral nevus of Ota-like macules remain uncertain. This study aims to evaluate the potential benefits and risks of using the 730-nm picosecond laser for ABNOM removal. This is a retrospective review of patients who were presented to the clinic between January 2020 and January 2024 for the treatment of ABNOM with 730-nm picosecond laser alone. The efficacy of the laser was assessed based on the Quartile Improvement Scale, using high-resolution photographs evaluated by blinded dermatologists. A total of 72 Chinese participants with Fitzpatrick skin types III to IV were included in the study. The overall effective rate of the treatment was 75%, achieved after an average of 2.42 ± 0.75 sessions. A subgroup analysis of 41 patients who completed 3 treatment sessions showed statistically significant differences in outcomes across the sessions. The mean improvement scores for sessions 1, 2, and 3 were 1.63 ± 1.04, 2.66 ± 1.22, and 3.29 ± 1.17, respectively (p < .01). No cases of hypopigmentation were observed. The incidence of postinflammatory hyperpigmentation was 5.56%. The 730-nm picosecond laser is a safe and effective treatment for ABNOM in Chinese patients.