Background: Resin-based composites (RBCs) provide excellent esthetics but the marginal micro-leakage in the proximal cavities remains a major concern. The aim of the present study was to assess the ability of various dental RBCs and techniques utilized for sealing deep dentin margin in class-II cavities. Methods: Box-cavities (class-II) on the distal and mesial surfaces of extracted (premolar) teeth were prepared with a gingival margin placed 1mm apical to the cemento-enamel junction. Teeth with prepared class II cavities were randomly divided into four study groups according to the type of restorative materials (conventional RBC; bulk-fill RBC; conventional RBC lined with flowable RBC and conventional RBC lined with resin-modified glass-ionomer-cement (GIC) as open sandwich-technique). Each group was further subdivided into a total-etch subgroup in which a separate etching step was performed before applying the bonding agent and a self-etch subgroup in which a self-etch adhesive system was used (n = 10). For each group, cavities were restored using the respective restorative materials and techniques, subjected to 1000 thermocycles, and placed in the methylene-blue dye. The specimen teeth were sectioned for further microscopic examination for micro-leakage. Results: The least dye penetration values were reported for group 4 (GIC) followed by the group Bulk-fill using the self-etch adhesive system (group 2b). The highest dye penetration was reported for the group Bulk-fill using the total-etch adhesive system (2a), followed by the group conventional RBC using the total-etch adhesive system). The total-etch adhesive system had significantly greater micro-leakage compared to the self-etch adhesive system (1a) (p = 0.026). Conclusions: The self-etch adhesive system significantly reduced the micro-leakage compared to the total-etch system. Bulk-fill RBC when bonded with the self-etch adhesive provided good marginal sealing ability comparable to open sandwich-technique using GIC.