Research on the establishment of a regional ecological network can provide a scientific basis and valuable guidance for the protection of regional animals and plants, water conservation, sustainable resource utilization, and optimization of land use patterns. This study investigated the impacts of land use changes on the ecological security pattern using morphological spatial pattern analysis (MSPA), the minimum cumulative resistance (MCR) model, and the analysis of spatiotemporal changes and fragmentation of land use types. The results indicate that from 2000 to 2020, the dominant trend in land use types was the expansion of cultivated land, grass land, and wood land. Although the proportion of cultivated land was the largest and was concentrated in the southern part of Hebei Province, the total area of cultivated land showed a decline. Landscape index calculations revealed an increase in fragmentation of the overall landscape ecological patches, while the spatial and quantitative distribution of landscape types gradually became more uniform. Furthermore, 52 patches with the highest landscape index were identified as ecological sources, mainly located in northern Hebei Province in 2020. MSPA calculations showed that elevation, slope, and land use type contributed significantly to the comprehensive resistance surface. Using the MCR model, an ecological network for Hebei Province was constructed, consisting of 114 ecological corridors and 28 ecological nodes. The ecological corridors exhibited a distribution pattern of high density in the north and low density in the south, while the ecological nodes enhanced overall ecological connectivity in the region. Based on the current ecological environment, it is recommended to increase the number of ecological corridors and ecological nodes to enhance ecosystem stability.