Type Of Hair Loss Research Articles

Phytochemicals in hair care: A review of natural ingredients and their applications

Phytochemicals are increasingly being used in hair care products due to their potential benefits for hair growth, strength, and texture. This review article discusses the various natural ingredients used in hair care products, including herbs, essential oils, and plant extracts. The article highlights the benefits of using phytochemicals in hair care, including their ability to promote hair growth, reduce, dandruff, and improve scalp health. The review also discusses the different types of hair loss, including alopecia areata, androgenetic alopecia, and telogen effluvium. Furthermore, the article explores the various applications of phytochemicals in hair care, including their use in hair oils. Overall, this review article provides a comprehensive overview of the use of phytochemicals in hair care and highlights their potential benefits for promoting healthy hair.

Impact of the COVID-19 pandemic on telogen effluvium: a nationwide multicentre interrupted time series study.

There is ongoing debate regarding the association between telogen effluvium (TE) and COVID-19, as well as COVID-19 vaccines. To investigate the impact of the COVID-19 pandemic and vaccination on the development of TE among patients visiting dermatology clinics in South Korea. Between 2017 and 2022, data regarding patients with TE and other types of hair loss were collected from 22 hospitals in South Korea. An interrupted time series analysis was conducted, dividing the time into periods before and after the COVID-19 pandemic, as well as before and after the COVID-19 vaccination. There was a significant slope change in the percentage of cases of TE during the postpandemic period (slope change 0.011, 95% confidence interval 0.005-0.017, P < 0.001), but no significant changes were observed after vaccination. The percentage of patients with other types of hair loss was not associated with COVID-19 or vaccination. The retrospective nature of the study may have limited the ability to establish causation. This multicentre study provides insights into the epidemiology of TE, showing a significant increase in cases of TE following the COVID-19 pandemic. However, there was no association between the occurrence of TE and COVID-19 vaccines.

Zinc Status in Kurdish Adults With Hair Loss.

Zinc is an essential element for hair growth and may act as a strong inhibitor in accelerating follicle regression, besides being an accelerator for the recovery of the hair follicle.This study investigated the status of zinc in Kurdish adults with hair loss and its relation with each of the four types of hair loss. We investigated the zinc status of a sample of Kurdish adults with hair loss who attended the Dermatology Outpatient Clinics at Azadi Teaching Hospital in Duhok, Kurdistan Region, Iraq. We included a total of 200 subjects in this study, of which 125 had hair loss with a diagnosis of alopecia areata, female pattern hair loss, male pattern hair loss, and telogen effluvium, and 75 were sex- and age-matched apparently healthy subjects without hair fall as a control group. Serum samples were used to measure zinc by colorimetric technique. In participants with hair loss, we found significantly lower serum zinc levels (p=0.002) compared with the control group. The telogen effluvium group had the lowest mean serum zinc level (p=0.006) and higher odds ratio compared with other hair loss groups (4.61). Overall, severe zinc deficiency was found in 12 (9.6%) subjects with hair loss, whereas none of the controls had severe zinc deficiency. Mild-to-moderate zinc deficiency was observed in 43 (34.4%) subjects with hair loss compared to one (1.3%) in the control group. Conclusions: Our results showed that lower zinc status is linked to hair loss, especially alopecia areata and telogen effluvium in the Kurdish population.

Effectiveness of platelet-rich plasma in treating female hair loss: A systematic review and meta-analysis of randomized controlled trials.

Hair loss profoundly affects women's physical appearance and psychological health. Platelet-rich plasma (PRP) therapy has gained attention as a potential treatment for female hair loss. This systematic review and meta-analysis aim to evaluate the efficacy and safety of PRP in treating different forms of female hair loss. A comprehensive search was conducted across PubMed, EMBASE, Scopus, Cochrane Library, Web of Science, and ClinicalTrials.gov from January 2000 to May 2024. The focus was on randomized controlled trials investigating PRP treatment for various types of hair loss in women. The research protocol is registered with International Prospective Register of Systematic Reviews (CRD42024556190). The quality of the studies was evaluated using the Cochrane risk of bias tool (RoB 2). A total of 21 studies comprising 628 participants were included in the analysis. PRP treatment was found to significantly enhance hair density and thickness. Additionally, there was a significant reduction in the number of hairs pulled in the PRP group. Adverse effects were generally mild and transient, with no notable difference in pain or discomfort between the PRP and control groups (risk ratio: 1.01; 95% CI: 0.87-1.18). PRP therapy effectively enhances hair density and thickness in women with hair loss, with a favorable safety profile. However, the effects of PRP on hair density and thickness vary with dosage, injection duration, and ethnicity, indicating the need for tailored treatment protocols.

A rare case of azathioprine induced anagen effluvium and plica neuropathica

Anagen effluvium is a type of hair loss that results from a sudden decrease in the metabolic activity of the hair follicle’s matrix cells. The condition is commonly associated with cancer treatments such as chemotherapy and radiation, but can also be caused by other factors. Plica neuropathica, on the other hand, is a condition where hair on the scalp becomes irreversibly matted. It is often linked to psychiatric disturbances, poor hair care, scalp infestations, and the use of ionic surfactants in shampoos. In rare cases, it has also been associated with certain medications. Here we present a rare case of a 16-year-old female who was on azathioprine and was diagnosed with an overlap of both conditions.

CBD: A Potential Lead against Hair Loss, Alopecia, and its Potential Mechanisms.

Nowadays, the majority of the population suffers from the problem of hair loss. It leads to disturbed mental health, lower self-confidence, and a lot more problems. A lot of the hair loss therapies available are not reliable and lead to recurrence and side effects after some time. Cannabinoids (CBD) have recently become quite popular for their benefits against hair loss. CBD oil preparations have been used both internally and externally for oral and topical use, respectively. Due to the presence of the endocannabinoid system (ECS) in the body, which naturally targets CB1 and CB2 receptors, the control of hair fall is possible. CBD is used topically for hair loss, whereas it is administered orally for the treatment and management of a medical condition, i.e., alopecia. The present review aimed to provide an in-depth study on hair loss and its management using CBD and its associated mechanisms. Electronic databases, such as ScienceDirect, Google Scholar, PubMed, Wiley, Springer, and Scopus, were thoroughly searched for information about how CBD is used, how it works, and what role it plays in treating alopecia and hair loss. This review has highlighted the use of CBD-based hair loss therapy, and described various types of hair loss and their treatments. This review also details the phytocannabinoids and the potential mechanisms of CBD's activity against hair loss and alopecia. The data obtained from the literature regarding CBD and hair loss provide a scientific basis for CBD use in alopecia. Additionally, a more precise and comprehensive study concerning CBD needs to be carried out at the pre-clinical and clinical levels.

Platelet-rich plasma therapy in the treatment of androgenic alopecia – review

Hair loss is a problem that affects many people around the world. Androgenic alopecia (AGA) is the most common cause of hair loss affecting up to 50% of men and 40% of women over the age of 50. This type of hair loss is mediated by androgens, the strongest of which is dihydrotestosterone (DHT). This hormone influences the weakening hair follicles. The problem of excess DHT and the associated androgenic hair loss may concern people practicing sports, especially aerobic disciplines of moderate and high intensity. In the recent decades, many topical and oral therapies have been introduced to delay and stop hair loss. However, commonly used medications have only a partial and temporary effect, therefore alternative treatment methods are needed. Platelet-rich plasma (PRP) is known, among other things, for its use in orthopedics. The use of PRP may benefit athletes in the treatment of injuries to tendons, ligaments, muscles and cartilage. Many publications indicate good results with the use of PRP in the treatment of hair loss.&#x0D; The aim of this study is to summarise the published reports on the effect of platelet-rich plasma (PRP) on hair loss prevention in people with androgenic alopecia (AGA) and to analyse the papers discussing androgen levels in physically active people.

Status of research on the development and regeneration of hair follicles.

Hair loss, or alopecia, is a prevalent condition in modern society that imposes substantial mental and psychological burden on individuals. The types of hair loss, include androgenetic alopecia, alopecia areata, and telogen effluvium; of them, androgenetic alopecia is the most common condition. Traditional treatment modalities mainly involve medical options, such as minoxidil, finasteride and surgical interventions, such as hair transplantation. However, these treatments still have many limitations. Therefore, exploring the pathogenesis of hair loss, specifically focusing on the development and regeneration of hair follicles (HFs), and developing new strategies for promoting hair regrowth are essential. Some emerging therapies for hair loss have gained prominence; these therapies include low-level laser therapy, micro needling, fractional radio frequency, platelet-rich plasma, and stem cell therapy. The aforementioned therapeutic strategies appear promising for hair loss management. In this review, we investigated the mechanisms underlying HF development and regeneration. For this, we studied the structure, development, cycle, and cellular function of HFs. In addition, we analyzed the symptoms, types, and causes of hair loss as well as its current conventional treatments. Our study provides an overview of the most effective regenerative medicine-based therapies for hair loss.

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

AbstractAlopecia is traditionally classified into scarring and nonscarring subtypes, with etiopathologies ranging from androgen‐mediated to immuno‐inflammatory. Over 50% of men and almost 50% of women will experience some form of hair loss in their lifetime. Given this prevalence and the psychosocial significance of hair, understanding the pathophysiology and comorbidities of different types of hair loss is imperative. Other proinflammatory dermatologic disorders, such as psoriasis, are recognised to have systemic manifestations including an increased risk of cardiovascular (CV) disease, and are now considered CV risk‐enhancing conditions. With increased recognition of the importance of systemic inflammation in promoting atherosclerosis, high prevalence, and improved treatment strategies, there is increased interest in establishing whether a similar association between alopecia and cardiovascular disease (CVD) exists. In this manuscript, we aim to review the current literature regarding CV risk in androgenic alopecia (AGA) and alopecia areata (AA). Additionally, we review the literature for cicatricial alopecias and highlight the need for more research into their potential associations with CV risk. Evidence from the identified AGA publications suggests an association of AGA with CV risk factors including hypertension, dyslipidemia, and insulin resistance, as well as with coronary artery disease. For AA, most of the identified studies found an association between AA and CV risk, though the relationships were not always statistically significant. Research on cicatricial alopecias and CV risk is limited and often contradictory. There is great need for more studies regarding the association between various types of alopecia and the development of CVD, and potential mechanisms. Particularly needed are more studies of cicatricial alopecias and potential associated CV risk. While some literature suggests that patients with alopecia have an increased risk of CVD, the lack of concrete evidence represents a notable gap in our current understanding.

Hair loss – A growing problem among medical students

Hair loss is a common problem that can affect people of different ages, genders, and professions. Medical students, in particular, may experience a higher rate of hair loss due to the rigorous academic curriculum, long hours of studying, high levels of stress, lack of sleep, and poor nutrition. This article discusses the various causes and types of hair loss, including genetic factors, stress, nutrition deficiencies, hormonal imbalances, and the use of chemicals. It also mentions the impact of COVID-19 on hair loss and the potential role of medications in treating hair loss. Overall, it emphasizes the importance of understanding and addressing the underlying causes of hair loss in medical students to promote their well-being and reduce the risk of hair loss.

Review of hair prosthetic options for patients with alopecia.

Advanced cases of alopecia can be very difficult to treat pharmacologically. Hair loss can be emotionally taxing for many, leading to depression, anxiety, or suicide. Currently, there is limited medical literature on prosthetic hair devices available for patients with alopecia. The purpose of this review is to educate dermatologists with a thorough review of hair prostheses to assist them in counseling patients with alopecia. We provide an overview of the various hair prostheses in detail and discuss their respective advantages and disadvantages. When considering the optimal hair prosthesis for a patient, it's important to know the hair coverage the patient requires, the material of different attachments, the type of hair fiber required, and the cap foundation. Additionally, financial options and potential adverse effects after applying a prosthesis to the scalp are important aspects to consider. A dermatologist should be able to discuss hair camouflaging techniques with their patients, including the benefits of the various options based on patients' preferences, needs, and type of hair loss. Dermatologists are the experts in the management of skin, nail, and hair disorders, and an understanding of the prosthetic options available to patients with alopecia can improve patient care and quality of life outcomes.

A Critical Analysis of the Usage of Herbal Products Amidst South Indian Population for the Treatment of Alopecia

ABSTRACT: This article describes herbal remedies and herbal products for alopecia. It mainly states the use of herbal preparations for the treatment of hair loss and also describes their advantages over synthetic products and drugs. As the use of herbal blends have least side effects, maximum efficacy, and are economically and easily prevalent, they can act as naturopathic medicines in treating various types of hair loss. Hair loss can be due to different reasons such as genetic tendency, extreme stress, nutritional deficiency, environmental triggers, exposure to chemicals etc. Hence use of synthetic compounds can show unfavorable outcomes such as scaling, dermatitis, pruritus and other skin related problems and to overcome such effects herbal products which are made by extraction of natural compounds mainly herbs are preferred as they play a role in patient compliance and show more than one mode of action for the treatment of alopecia. The article basically gives the description of various herbal products, remedies and also herbal products with nutrient supplements available with their brand name, manufacturing details along with their cost, indications which can be beneficial to treat hair loss.

BH02 Online psychological support for patients with alopecia areata: an evaluation of available online psychological support material based on the National Centre for Complementary and Integrated Health guidelines

Abstract Alopecia areata is an autoimmune disorder causing nonscarring hair loss that is associated with significant psychological comorbidity (Macbeth AE, Holmes S, Harries M et al. The associated burden of mental health conditions in alopecia areata: a population-based study in UK primary care. Br J Dermatol 2022; 187:73–81). In addition to seeking psychological support from medical professionals, patients will often turn to online resources. In this study, we evaluated the range and quality of the online psychological support material available for patients with alopecia areata. A Google search was undertaken using private browsing on 5 June 2022, with several search terms: ‘alopecia areata online support group UK’, ‘alopecia support’ and ‘alopecia areata psychology’. The National Centre for Complementary and Integrated Health (NCCIH) guidelines for the evaluation of online resources were used. These guidelines assess information source and accuracy, funding, peer review status, linking policies and contemporaneity. Our search generated a total of 154 000 results. Advertisements, scientific articles, educational resources and duplicates were excluded, with nine resources included in the final analysis. Of the nine resources reviewed, three were specific for patients with alopecia areata, with the remaining resources focused on other types of hair loss. Six were authored or reviewed by dermatologists and seven had a documented peer review process of their content. One resource had no clear authorship and three had no clear peer review process. Nine of the resources were charity funded and one was a National Health Service resource. Four had been updated in the last 3 years and a further two within 5 years. All resources had clearly documented security and linking policies. All resources acknowledged the psychological impact of hair loss and eight had links to support groups or discussion forums. Only five had psychological support and advice on their website, with others only referring to the psychological burden and then signposting patients on to other sources for support. Only three of the resources referred to therapies such as cognitive behavioural therapy. The prevalence of mental health comorbidity in alopecia areata is high compared to the general population (Macbeth et al.). Our preliminary study has shown that the online psychological support available is lacking. With patients increasingly turning to the Internet for support and health information, there is an opportunity and need for development in this area.

Evaluation of the Relationship between Favipiravir Use Status and Telogen Effluvium in Patients Diagnosed with COVID-19

Favipiravir (FVP) is a competitive inhibitor of viral RNA-dependent RNA polymerase and is also a purine nucleoside analogue. It produces antiviral activity against the SARS-CoV-2 virus and has been used to treat COVID-19. Telogen effluvium (TE) is a widespread, non-scarring shedding due to the early entry of hair during the telogen phase. The most prevalent causes are drugs, physiological and emotional stress, surgery, high fever, chronic infections, diet, iron deficiency, and smoking. In this study, we investigated whether there was a significant difference in terms of TE by questioning the patients who had coronavirus in the last 1 year, and who received and did not receive FVP treatment. This study included patients aged 18-65 years old who applied to the Karaman Training and Research Hospital, Dermatology, and Venereal Diseases outpatient clinic complaining of hair loss and having had COVID-19 in the last year. We confirmed the diagnosis of TE by using trichoscopy on patients with a positive pull test. We investigated whether there was a difference in terms of TE and other types of hair loss between patients who received FVP treatment and those who did not. For the study Karamanoglu Mehmet Bey University ethics committee approval was obtained (June 16, 2022). As a result of comparing the patients' gender, comorbidity, pull test, and thyroscopic findings according to the use of FVP, it was clear that most of the FVP users were women (p = 0.027). Among those who did not use FVP, positive pull test scores were significantly higher (p = 0.026). The fact that the pull test was significantly lower in patients in our study using FVP may suggest that FVP has no effect on TE’s development. We did not find any study on its effect on alopecia and TE. We think that our study is also important in this respect.

Traction alopecia: assessing the presentation, management and outcomes in a diverse urban population.

Traction alopecia (TA) is a type of hair loss caused by repetitive tension placed on the hair follicle. An institutional review board-approved retrospective study was conducted at a single institution located in the Bronx, New York. The review identified 216 unique patients with TA and collected information on demographics, patient presentation, history, physical exam, treatment, follow-up and disease improvement. Almost all patients identified as female (98.6%), and most were Black or African American (72.7%). Mean (SD) age was 41.3 (17.1) years (median 40 years; range 1-88). Patients reported hair loss for a mean duration of 35 (51.1) months (median 18 months; range 1-264) prior to presentation. Most patients experienced asymptomatic hair loss. Around half (49.1%) of the patients attended a follow-up, with 42.5% of these patients noting improvement in hair loss or symptoms across all visits. Duration of hair loss was not associated with improvement in hair loss at follow-up visit (P = 0.23).

The association of hair loss and coronavirus infection COVID-19 – facts and hypotheses

The main manifestations of COVID-19 are primarily interstitial pneumonia and respiratory failure. No less than 20% of patients have variable skin rashes, which try to be interpreted as markers and predictors of the peculiarities of the course of coronavirus infection. In addition, hair loss is a characteristic manifestation of COVID-19, and the salivary follicles are regarded as a target for SARS-CoV-2. The most common variants of alopecia in patients with a new coronavirus infection or vaccine-induced alopecia are acute telogenic, nondescript, and androgenetic alopecia. This review provides information on the most common variants of hair loss in patients with SARS-CoV-2 infection, the features of their manifestations, and possible mechanisms of development. Acute telogenic hair loss is the most common variant of SARS-CoV-2-induced alopecia, is characteristic of patients with subacute course of COVID-19 and can be combined with trichodynia, anosmia and aguvia, which are markers of nervous syste damage. Given the variability in the time of onset after infection, a heterogeneous pathogenesis of alopecia can be assumed. Nested alopecia after COVID-19 is often a relapse of the disease, its severity and frequency do not correlate with the severity of the infectious disease, and its prevalence in women indicates the importance of hormonal factors in its development. Androgenetic alopecia may be a predictor of high risk of infection, severe course, and recurrence of COVID-19. The first two variants of alopecia may be associated with COVID-19 vaccination, and the latter is a predictor of inadequate immune response to vaccine administration. The mechanisms of the damaging effects of SARS-CoV-2 on hair follicles have not been fully deciphered and are most likely complex, with different leading links in different types of hair loss. Deciphering these mechanisms may provide prerequisites for understanding the mechanisms of COVID-19 damage to other tissues and organs.

TRACTON ALOPECIA: AN UNDER REPORTED COMMON CAUSE OF HAIR LOSS IN CHILDREN.

Traction alopecia is a type of hair loss caused due to mechanical trauma to the hair by traumatic hairstyling with continued long term traction. This can be secondary to social, cultural, religious or occupational practices. The hair loss depends on the extent, force and the duration of the traction. This non-scarring form of hair loss if not addressed early can lead to permanent scarring alopecia. In most of the patients, this is an accidental diagnosis especially in school going girls in India where they need to tie tight braids as a part of their curriculum. In this article, we report a case series of traction alopecia with emphasis on its early diagnosis, clinical features and management

The CROWNing Event on Hair Loss in Women of Color: A Framework for Advocacy and Community Engagement (FACE) Survey Analysis.

Hair loss is a primary reason for women with skin of color to seek dermatologic care. In addition to physical disfigurement, patients with hair loss are more likely to report feelings of depression, anxiety, and low self-esteem. There is a critical gap in dermatology advocacy efforts and educational information intended for women with skin of color. In July 2021, the Virginia Dermatology Society planned a virtual event on hair loss and practical political advocacy for women of color. Event attendees completed pre- and postevent Likert scale surveys that assessed participant attitudes, knowledge, and awareness surrounding hair loss. A resource toolkit for both patients and physicians also was created, which included articles about evaluating, diagnosing, and treating different types of hair loss that would be beneficial for dermatologists, as well as informational articles, links, and videos that would be helpful to patients. Resource toolkits combined with outreach events can be used to engage communities, disseminate information, and close gaps that have led to health care disparities.

701 Rethinking alopecia scores: Correlating measures of hair loss with established photographic scoring systems

Alopecia scoring systems have traditionally been designed to assess and track severity and progression of specific types of alopecia. Each scoring system’s design and clinical validation is limited to only one alopecia type (e.g., Severity of Alopecia Tool score for alopecia areata (AA), Sinclair visual analogue scale for female pattern hair loss (FPHL), Olsen top extent scale for central centrifugal cicatricial alopecia (CCCA)), even though all forms of alopecia share a common feature of decreasing hair density. We propose that a scoring system that measures percent hair loss would be useful across different types of hair loss. We tested correlations between the AA, FPHL, and CCCA scoring systems and the underlying percent hair loss. On a dataset of 284 top-view scalp images taken from 250 subjects, 3 raters manually scored each image using the 3 different scoring systems. After an intraclass correlation analysis demonstrated reliability between the raters, we established a final consensus set of 3 scores per image. Using regression models, we analyzed the score correlations within and across alopecia types. Our results suggest that there is a precise and quantifiable correlation between these scoring systems and the underlying hair loss percent: both CCCA and FPHL scoring systems show a logarithmic relationship with respect to percent scalp area affected (a proxy for the AA scale), resulting in an R2 of 0.793 and 0.804, respectively. Additionally, the CCCA and FPHL scoring systems show a linear relationship with each other, resulting in an R2 of 0.963. These findings suggest that distinct alopecia scoring systems measure percent hair loss as a common underlying feature, and that an automated algorithm quantifying this percent hair loss from photographs may be designed and applied to all forms of hair loss.

The role of SARS-CoV-2 infection and its vaccines in various types of hair loss.

The prevalence of hair loss has increased during COVID‐19. In this study, we review the current literature on incidence and characteristics of various types of COVID‐19‐related and COVID‐19‐vaccine‐ related hair loss including telogen effluvium, alopecia areata, friction alopecia and anagen effluvium. Regarding most of them, the more severe the infection, the more profound and prolonged the course of alopecia. However, the most important issue is reassuring the patients of the non‐serious nature of this complication, since psychological support is the most important factor in the earlier resolution of the condition.