Abstract In northern New Brunswick, vegetation samples were gathered from an area of known gold mineralization (Elmtree property) and from the surrounding 30×30 sq. km region. Abundances of Au and gold indicator elements in leaf tissue were much greater over the mineralized area than in the surrounding region whereas abundances of some base metals, notably Zn, were greater in regional samples. LANDSAT TM reflectance data were distinctly different over the Elmtree property as compared to the surrounding areas. In particular, spectral response for TM bands 5 and 7 was significantly greater whereas response for TM band 3 was less. The spectral signature from the Elmtree property was found to be duplicated in 0.79% of the entire study area. These regions of predicted vegetation stress were associated with anomalous abundances of Au in till 5.5 times more often than would have been predicted from a random distribution of predicted stress areas. This study illustrates that biogeochemical and vegetation reflectance data can be useful in characterizing this type of gold mineralization in northern New Brunswick and as a tool in defining exploration targets on a regional basis.