Event Abstract Back to Event Brain state dependent firing patterns of identified interneurons in the medial prefrontal cortex K. Hartwich1, 2*, T. Klausberger1, 2 and L. Massi1, 2 1 Anatomical Neuropharmacology Unit, United Kingdom 2 Medical University of Vienna, Center for Brain Research, Austria In the medial prefrontal cortex, distinct types of neuron form intricate circuits and cooperate in time to support complex operations including working memory, attention and decision making. So far we cannot explain how prefrontal activity is synchronised during altering brain state dependent oscillations based on the spatio-temporal interaction of its organisational elements. To understand the contribution of different types of GABAergic interneuron, we recorded single cells in the medial prefrontal cortex and simultaneously the prefrontal and hippocampal local field potentials in anaesthetised rats. Subsequently, the cells were juxtacellularly labelled and we investigated their axo-dendritic arborisations, expression of molecular markers, postsynaptic targets and spiking activity during different oscillatory frequency bands. Using this approach, we have recently shown that parvalbumin and calbindin expressing basket cells contribute to the synchronisation of local pyramidal cell discharge during hippocampal theta and cortical spindle oscillations, suggesting their strong involvement in timing prefrontal activity to varying inputs. In contrast, calbindin expressing and parvalbumin immuno-negative dendritic-targeting cells are not involved in the oscillation-related timing of pyramidal cell firing during either network activity. Here, we investigate the spike timing of other types of identified GABAergic interneurons during various oscillatory frequency bands and discuss how pyramidal cell synchronisation in the medial prefrontal cortex can be explained by the precise spatio-temporal differentiation of the cell-type specific GABAergic inputs. Conference: EMBO workshop: Gaba Signalling and Brain Networks , Amsterdam, Netherlands, 30 Jun - 2 Jul, 2010. Presentation Type: Poster Presentation Topic: Posters Citation: Hartwich K, Klausberger T and Massi L (2010). Brain state dependent firing patterns of identified interneurons in the medial prefrontal cortex. Conference Abstract: EMBO workshop: Gaba Signalling and Brain Networks . doi: 10.3389/conf.fnins.2010.15.00009 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Jun 2010; Published Online: 23 Jun 2010. * Correspondence: K. Hartwich, Anatomical Neuropharmacology Unit, Oxford, United Kingdom, katjahartwich@gmx.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers K. Hartwich T. Klausberger L. Massi Google K. Hartwich T. Klausberger L. Massi Google Scholar K. Hartwich T. Klausberger L. Massi PubMed K. Hartwich T. Klausberger L. Massi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.