Open holes or cut-outs have been commonly used in composite structures for various engineering purposes. Those elements often demand perforation especially for weight reduction and to ease maintenance and servicing operations, for example, in aircraft wing ribs. This work presents a numerical study of the stability behavior of composite perforated columns subjected to a compressive load. Profiles were made of CFRP laminate and weakened by three types of cut-out. Four parameters, spacing ratio S/D0, opening ratio D/D0, hole shape and arrangement of layers, were selected to check their effect on the buckling load and postbuckling behavior of the tested channel profiles. To carry out the numerical analysis, the Abaqus software was used. The results obtained during the analysis helped to identify the best combination of tested parameters to obtain the highest critical load. The performed analysis show that the columns' behavior is sensitive to configuration of composite, opening ratio and hole shape.