Osteoid osteoma (OO) is a benign bone tumor that can cause significant pain and negatively affect daily life for patients. Surgical resection and multiple percutaneous techniques have been utilized in the treatment of osteoid osteomas. We report our institutional experience with cryoablation in the treatment of OO in pediatric patients. A retrospective review of 11 patients from 2014-2017 with a confirmed OO and who underwent cryoablation by a single interventional radiologist was completed. Demographic, subjective, clinical, imaging, and pathological information were collected. Pre- and post-pain scales were recorded to determine if symptom relief was achieved. Bone biopsies were analyzed for concordance with clinical/imaging diagnosis. Details of the procedure, such as imaging modality used, technical success, procedure time, radiation exposure, and complications of each procedure were analyzed. All patients presented with classical symptoms with an average age of 12.1, and 82% were male. The average duration of pain was 11 months and 91% reported regular NSAID use prior to cryoablation. The average nidus size was 9.7 mm. A 100% technical success rate was achieved with 60% of patients having a concordant biopsy. There was a significant reduction in numeric pain scales from an average of 7 out of 10 before to an average of 0 after the procedure (p = 0.003). A total of 3 self-limiting complications were reported after the procedure: one patient reported skin blistering and two presented with temporary nerve injury. There was no significant difference in procedure time, radiation exposure, and technical success between the two types of CT scanners used (p > 0.05). Adequate symptom relief can be achieved with percutaneous cryoablation, which is an effective alternative to other percutaneous techniques or surgical resection in the treatment of osteoid osteoma.