Type Of Aphasia Research Articles

Eye movements of persons with aphasia during connected-text reading

ABSTRACT Background Eye movements reflect the cognitive-linguistic processing of neurotypical readers. Numerous reading related eye movement measures are associated with language processing, including first fixation duration, gaze duration, number of fixations, word skipping, and regressions. Eye movements have also been used to examine reading in neuro-atypical populations including persons with aphasia (PWA). Aims This study aimed to determine whether eye movement measures obtained from connected text reading differ among persons with varying types of aphasia and neurotypical individuals, as well as whether eye movement measures are associated with language processing severity and reading comprehension ability in PWA. Methods Twenty-four PWA and twenty-four age-matched control participants completed a connected text-reading eye-tracking task. The PWA also completed assessments to evaluate overall language processing severity and reading comprehension skills and to identify specific subtypes of aphasia. Results Persons with aphasia had shorter gaze duration, longer regression duration, and made more fixations than control participants, while no group differences emerged for first fixation duration or word skipping. Eye movement patterns did not differ among participants with anomic, Broca’s, or conduction/Wernicke’s. Language severity scores were a significant factor for gaze duration, while reading comprehension scores were not a significant factor for the eye movement measures examined. Conclusions The findings support previous eye tracking literature that indicate different eye movement patterns for persons with aphasia during text reading relative to neurotypical controls. The findings also highlight that the selection of eye movement measures examined, the stimuli used, and procedural considerations may impact the pattern of results. The results from this study can be used to further determine which eye movement measures may be most suited for studying language processing during reading in neuro-atypical individuals and determine whether persons with aphasia use different strategies for reading comprehension than neurotypical individuals.

The Flu-ID: A New Evidence-Based Method of Assessing Fluency in Aphasia.

Assessing fluency in aphasia is diagnostically important for determining aphasia type and severity and therapeutically important for determining appropriate treatment targets. However, wide variability in the measures and criteria used to assess fluency, as revealed by a recent survey of clinicians (Gordon & Clough, 2022), results in poor reliability. Furthermore, poor specificity in many fluency measures makes it difficult to identify the underlying impairments. Here, we introduce the Flu-ID Aphasia, an evidence-based tool that provides a more informative method of assessing fluency by capturing the range of behaviors that can affect the flow of speech in aphasia. The development of the Flu-ID was based on prior evidence about factors underlying fluency (Clough & Gordon, 2020; Gordon & Clough, 2020) and clinical perceptions about the measurement of fluency (Gordon & Clough, 2022). Clinical utility is maximized by automated counting of fluency behaviors in an Excel template. Reliability is maximized by outlining thorough guidelines for transcription and coding. Eighteen narrative samples representing a range of fluency were coded independently by the authors to examine the Flu-ID's utility, reliability, and validity. Overall reliability was very good, with point-to-point agreement of 86% between coders. Ten of the 12 dimensions showed good to excellent reliability. Validity analyses indicated that Flu-ID scores were similar to clinician ratings on some dimensions, but differed on others. Possible reasons and implications of the discrepancies are discussed, along with opportunities for improvement. The Flu-ID assesses fluency in aphasia using a consistent and comprehensive set of measures and semi-automated procedures to generate individual fluency profiles. The profiles generated in the current study illustrate how similar ratings of fluency can arise from different underlying impairments. Supplemental materials include an analysis template, extensive guidelines for transcription and coding, a completed sample, and a quick reference guide. https://doi.org/10.23641/asha.27078199.

Evaluation of Rituximab in Immunothrombocytopenia Splenectomized and Non-Splenectomized Patient

Stroke carries a high risk of death. Survivors can experience loss of vision and/or speech, paralysis and confusion. The risk of death depends on the type of stroke and its incidence increases with advancing age. Post-stroke aphasia and language impairment are significant health problems among stroke patients and may result in considerable activity limitation. Different types of aphasia might develop according to the location of the stroke. To identify the types of aphasia in patients with stroke and to assess the relationship between the age and types of aphasia in each type of stroke in those patients. This was a hospital-based cross-sectional study conducted at Bagdad Teaching Hospital, Medical City and Al Imamin Al Kazmain Medical City during the period from October 2014 to the end of September 2015. One hundred patients were enrolled and assessed at neurology and general medical wards. Clinical assessment of the aphasic patient was performed through clinical and language examination was performed. Statistical analysis was performed using the statistical package for Social Sciences version 22 and the appropriate statistical tests were used accordingly. The mean age of the studied group was 62.1 ± 13.2 (range: 37-87) years and the majority of the patients aged more than 50 years. Females represented 55% of the patients. Ischemic and hemorrhagic strokes were reported in 76% and 24% of patients, respectively. Global aphasia was found in 32%, Broca´s(17%), Thalamic 17 (17%), Putaminal(11%), and Werneck’s (11%) of the patients, other types were less frequent. Hypertension was the most frequent risk factor reported among the patients Heart failure was the commonest reported cardiac factor. Aphasia was more frequent among patients older than 50 years. No statistically significant association had been found between the age and the types of aphasia (P>0.05). Global, Broca´sWernick´saphasia were significantly associated with ischemic stroke, while Thalamic, Putaminal conduction and anomia were associated with hemorrhagic stroke, (P<0.05). Hyperlipidemia and diabetes mellitus were significantly associated with Ischemic stroke rather than hemorrhagic (P=0.010). Cardiac risk factors were significantly associated with Ischemic stroke, (P = 0.038).7 Aphasia was more frequent with older age, and no significant association had been found between the type of aphasia and the age, generally, no significant association had been found between the types of aphasia and the risk factors, but some types were associated significantly with hypertension, smoking and diabetes mellitus. Further studies are suggested for further assessment.

Time reference in French-speaking people with fluent and non-fluent aphasia (part II): a cluster analysis

ABSTRACT Background Tense production is often impaired in people with aphasia (PWA). Interestingly, the literature suggests that not all tenses are affected in the same way, although the pattern of dissociation is still debated in the literature. The heterogeneity of tense production deficits in PWA might partly explain this lack of consensus in the literature. While this heterogeneity has been demonstrated by descriptive statistics or double dissociations in several studies, no study has used cluster analyses to highlight the main patterns of tense dissociation. Furthermore, the factors underlying this heterogeneity have been little explored. Aims Our study aimed to use cluster analyses on tense production performance to (1) identify the main patterns of dissociation between tenses in PWA and (2) explore the clinical (aphasia type and severity) and cognitive (executive disorders and temporality) factors that may underlie these patterns. Methods & procedures Twenty-one French-speaking participants with fluent and non-fluent aphasia completed a verb inflection production task, as well as language and cognitive tests. Cluster analyses were performed on the differences in performance between the tenses on the verb inflection production task. Generalized linear mixed models and nonparametric statistics were used to analyze the effect of tense and its interaction with the clusters, and to compare the clusters on the clinical and cognitive variables. Outcomes & results Cluster analyses revealed two main clusters, one with worse performances in the past and future than in the present (PWA_1 – 70% of the PWA), and the other with worse performances in the past and present than in the future (PWA_2 – 30%). The type and severity of aphasia, and cognitive test performance did not differ between the two clusters. On the other hand, the PWA_2 cluster had a longer time post-onset than the PWA_1 cluster. Conclusions Our results confirm the heterogeneity of verb inflection deficits in PWA. They suggest that most PWA would have difficulties with past and future tenses, questioning the presence of discourse linking in these two tenses. However, a minority of PWA, who are clinically and cognitively indistinguishable from the others, do not follow this pattern. Adopting the strategy of producing a morphologically simple tense in French – future – could explain the high performance in the future tense and the errors in substituting other tenses with the future in this subgroup. Finally, the clinical and research implications of this heterogeneity, in relation to therapies and the lack of consensus in the literature, are discussed.

Language and executive functions in patients with transcortical motor aphasia and Broca’s aphasia

ABSTRACT This study investigated language and executive functions (EF) in people with transcortical motor aphasia (TMA) and Broca’s aphasia (BA). Participants included 19 patients with TMA, 19 patients with BA, and 25 healthy controls. Verbal Fluency tests, Stroop tests and Trail-Making tests were administered to all participants, and the Boston Diagnostic Aphasia Examination (BDAE) was administered to participants with aphasia. Results showed that (1) both groups of patients with aphasia had poorer performance on Verbal Fluency tests, Stroop tests and Trail-Making tests than healthy controls; (2) participants with BA had superior performance on Stroop tests and Trail-Making tests, but not on Verbal Fluency tests, than participants with TMA, and (2) the performance on Verbal Fluency tests, Stroop tests and Trail-Making was significantly correlated with the performance on BDAE for participants with TMA, but not for participants with BA. These results suggest that EF deficits are present in both patients with TMA and those with BA. They also show that the relationship between EF deficits and language impairments in people with aphasia might depend on the type of aphasia, aspects of language, and the components of EF measured.

Impact of Aphasia on Brain Activation to Motor Commands in Patients with Acute Intracerebral Hemorrhage.

Brain activation to motor commands is seen in 15% of clinically unresponsive patients with acute brain injury. This state called cognitive motor dissociation (CMD) is detectable by electroencephalogram (EEG) or functional magnetic resonance imaging, predicts long-term recovery, and is recommended by recent guidelines to support prognostication. However, false negative CMD results are a particular concern, and occult aphasia in clinically unresponsive patients may be a major factor. This study aimed to quantify the impact of aphasia on CMD testing. We prospectively studied 61 intensive care unit patients admitted with acute primary intracerebral hemorrhage (ICH) who had behavioral evidence of command following or were able to mimic motor commands. All patients underwent an EEG-based motor command paradigm used to detect CMD and comprehensive aphasia assessments. Logistic regression was used to identify predictors of brain activation, including aphasia types and associations with recovery of independence (Glasgow Outcome Scale-Extended score ≥ 4). Of 61 patients, 50 completed aphasia and the EEG-based motor command paradigm. A total of 72% (n = 36) were diagnosed with aphasia. Patients with impaired comprehension (i.e., receptive or global aphasia) were less likely to show brain activation than those with intact comprehension (odds ratio [OR] 0.23 [95% confidence interval 0.05-0.89], p = 0.04). Brain activation was independently associated with Glasgow Outcome Scale-Extended ≥ 4 by 12months (OR 2.4 [95% confidence interval 1.2-5.0], p = 0.01) accounting for the Functional Outcome in Patients with Primary ICH score (OR1.3 [95% confidence interval 1.0-1.8], p = 0.01). Brain activation to motor commands is four times less likely for patients with primary ICH with impaired comprehension. False negative results due to occult receptive aphasia need to be considered when interpreting CMD testing. Early detection of brain activation may help predict long-term recovery in conscious patients with ICH.

Typing Versus Handwriting: A Preliminary Investigation of Modality Effects in the Writing Output of People With Aphasia.

Handwriting and typing have different cognitive and motor demands; however, questions remain as to whether performance in people with aphasia varies based on modality. This study compares written discourse production across handwritten and onscreen typed modalities for a large sample of people with aphasia. We also aimed to explore potential variables that predict the number of written words generated by participants and determine if modality differences emerge when these variables are included as predictors. Writing samples, via handwriting and onscreen typing, elicited in a picture description task were collected from 52 participants with chronic aphasia and coded for number of words. Generalized linear mixed-effects models were used to model the data. Aphasia type, severity of aphasia, writing severity, and use of nondominant hand for writing or onscreen typing were included as predictor variables. There were no significant differences between the number of words generated in the typed modality versus handwritten modality for the sample. Of the predictor variables examined, Western Aphasia Battery-Revised writing scores significantly predicted the number of words produced (p < .001). However, the interaction of writing severity with modality was not significant. This preliminary study suggests that there was no effect of modality on one measure of written production, number of words. Future research is needed to evaluate if there are meaningful differences between modalities when additional measures, such as writing informativeness, are considered. https://doi.org/10.23641/asha.26506144.

Picture Naming Properties of Turkish People with Fluent and Non-Fluent Aphasia

Objectives: People with aphasia (PWA) have naming problems. During naming activities, they produce paraphasias. However, there is no significant association between paraphasia and aphasia types. This study aimed to identify the relationship between paraphasia and aphasia type, as well as the effect of cueing on naming performance. Materials and Methods: The study comprised 37 Turkish PWA who were divided into two groups: fluent and non-fluent aphasia. Participants were presented with 40 pictures and asked to name them. Cues were given in case they did not answer correctly. The participants' answers, the types of paraphasias, and how they responded to the cues were all recorded. Results: Participants in both groups significantly increased their naming performance for all words when cues were given. A total of 181 paraphasias were observed in the fluent aphasia group: Phonemic paraphasias were the most common (41.4%), followed by semantic paraphasias with 32.1%. There were 270 paraphasias in the non-fluent aphasia group, with phonemic paraphasia being the most common (60.7%). Conclusion: Phonemic and neologistic paraphasias were significantly higher in the non-fluent group. Phonemic and neologistic paraphasia is more common in those with non-fluent aphasia. This study found that the cueing method had a favourable influence on PWAs' naming performance, which is consistent with prior research.

Automated Analysis of Fluency Behaviors in Aphasia.

This study explored the use of an automated language analysis tool, FLUCALC, for measuring fluency in aphasia. The purpose was to determine whether CLAN's FLUCALC command could produce efficient, objective outcome measures for salient aspects of fluency in aphasia. The FLUCALC command was used on CHAT transcripts of Cinderella stories from people with aphasia (PWA; n = 281) and controls (n = 257) in the AphasiaBank database. PWA produced significantly fewer total words, fewer words per minute, more pausing, more repetitions, more revisions, and more phonological fragments than controls, with only one exception: The Wernicke's group was similar to the control group in percentage of filled pauses. Individuals with Broca's aphasia had significantly longer inter-utterance pauses and fewer total words than all other aphasia groups. Both the Broca's and conduction aphasia groups had higher percentages of phrase repetitions than the NABW (NotAphasicByWAB) group. The conduction aphasia group also had a higher percentage of phrase revisions than the NABW and the anomic aphasia groups. Principal components analysis revealed two principal components that accounted for around 60% of the variance and related to quantity of output, rate of speech, and quality of output. The Gaussian mixture models showed that the participants clustered in three groups, which corresponded predominantly to the controls, the nonfluent aphasia group, and the remaining aphasia groups (all classically fluent aphasia types). FLUCALC is an efficient way to measure objective fluency behaviors in language samples in aphasia. Automated analyses of objective fluency behaviors on large samples of adults with and without aphasia can produce measures that can be used by researchers and clinicians to better understand and track salient aspects of fluency in aphasia. https://doi.org/10.23641/asha.25979863.

Telepractice in Aphasia: Troubleshooting and Planning Assessments Using the Virtual-Appropriate Decision Approach

Purpose: This article describes the use of the Virtual-Appropriate Decision Approach (VADA). VADA is a systematic data gathering and problem-solving approach for planning and troubleshooting human, setting, and technology-related issues that may arise when conducting aphasia assessments via telepractice. Case examples are provided to illustrate and discuss its application for clinical and research settings. Method: We describe how VADA was used to analyze and mitigate challenges during administration of aphasia assessments in five (four cisgender males, one cisgender female) research participants via telepractice. Case discussions are organized by aphasia types and identify a variety of human, setting, and technology-related issues, which are analyzed via the VADA framework. Successes, challenges, and recommendations for conducting aphasia assessment via telepractice are included for each case. Conclusions: Unique challenges exist when using telepractice to conduct clinically valid standardized aphasia assessments for research or in the clinic. VADA is a systematic process to gather, analyze, evaluate, and address human, setting, and technology factors that impact aphasia assessments conducted via telepractice. The use of aphasia-friendly printed materials, assistance from communication partners, and similar task practice were adaptations that helped facilitate the assessment process.

Exploring the use of co-speech hand gestures as treatment outcome measures for aphasia

ABSTRACT Background Research on aphasia treatments that directly target conversation skills have been on the rise in the recent past. Despite the ubiquitous nature of gestures in everyday conversations and their possible compensatory and/or supportive functions for adults with aphasia, the conversational treatment outcome measures continue to rely on spoken language alone. Aims We aimed to explore the feasibility of using co-speech hand gestures as a treatment outcome measure in Clyde, an individual with chronic and severe Wernicke’s aphasia. Methods & Procedures Using a multiple-probe single-case experimental research, we examined data from one participant with aphasia (Clyde) who was a part of a larger study involving 3 people with aphasia (Devanga, 2020). 10-minute conversations between Clyde and clinician, and Clyde and his spouse, were completed during 3 baseline probes, 3 treatment probes and 3 maintenance probes. Clyde also completed a 15-session Collaborative Referencing Intervention (CRI; Devanga etal., 2021) with the clinician. The 18 conversation samples were videorecorded, transcribed, and analysed. Outcomes & Results The outcomes analysed included overall gesture frequency and type (i.e., referential vs. non-referential) across sessions (baseline – treatment – maintenance) and partner familiarity (clinician – spouse). We also compared the gesture outcomes with the spoken language measure, CIUconv (Correct Information Units). Overall gesture frequency was higher with the clinician than the spouse, and the frequency of referential gestures were higher than the non-referential gestures with both partners. With the onset of treatment, we found that overall gesture frequency decreased and #CIUconv increased with the clinician, however there were minimal variations across phases with the spouse. Additionally, with the onset of treatment, referential gestures decreased, and non-referential gestures increased with both partners. Conclusions Findings from this exploratory study provide preliminary support to using co-speech hand gestures as treatment outcome measures for aphasia. Clinical implications including comparisons of gestural outcomes with spoken language outcomes and their implementation are discussed. Further research on differences in gesture use among aphasia types and severities and patterns of change in gesture use with aphasia treatment is warranted.

Right versus left temporal lobe semiology in dementia: Lessons from two cases with focal frontotemporal dementia syndromes.

Focal atrophy of the left anterior temporal lobe has been associated with the semantic type of primary progressive aphasia evolving to semantic dementia. In contrast, focal atrophy of the right temporal lobe has more recently been described as a controverse entity reported as the right temporal variant of FTD. We describe two cases of FTD dementia syndromes: in Case 1, atrophy of the right temporal lobe led to significant behavioural impairment and difficulties in recognizing known people. In Case 2, atrophy of the left temporal lobe was associated with severe aggressive, ritualistic behaviour and aphasia.

Subcortical Aphasia

Aphasia, a language deficit caused by an acquired cerebral lesion was initially believed to be triggered exclusively by cortical damage. However, recent findings have confirmed that aphasia can also arise from subcortical lesions. This paper presents a case of a 53-year-old man with acquired language impairment associated with a lesion in the left lenticular nucleus caused by a hemorrhagic cerebrovascular event. The patient exhibited clinical and imaging characteristics consistent with subcortical aphasia of the thalamic and striato-capsular type. Subcortical structures are increasingly recognized for their involvement in language processing, alongside the cerebral cortex. Despite current acceptance of subcortical aphasia, there are limited studies on this type of aphasia and its interlinguistic variations. Consequently, extensive research is warranted to gain a better understanding of it as a clinical entity.

Gesture's Role in the Communication of Adults With Different Types of Aphasia.

Adults with aphasia gesture more than adults without aphasia. However, less is known about the role of gesture in different discourse contexts for individuals with different types of aphasia. In this study, we asked whether patterns of speech and gesture production of individuals with aphasia vary by aphasia and discourse type and also differ from the speech and gestures produced by adults without aphasia. We compared the amount, diversity, and complexity of speech and gesture production in adults with anomic or Broca's aphasia and adults with no aphasia (n = 20/group) in their first- versus third-person narratives. Adults with Broca's aphasia showed the lowest performance in their amount, diversity, and complexity of speech production, followed by adults with anomic aphasia and adults without aphasia. This pattern was reversed for gesture production. Speech and gesture production also varied by discourse context. Adults with either type of aphasia used a lower amount of and less diverse speech in third-person than in first-person narratives; this pattern was also reversed for gesture production. Overall, our results provide evidence for a compensatory role of gesture in aphasia communication. Adults with Broca's aphasia, who showed the greatest speech production difficulties, also relied most on gesture, and this pattern was particularly pronounced in the third-person narrative context.

Positive effects of speech and language therapy group interventions in primary progressive aphasia: A systematic review.

Primary progressive aphasia (PPA) is a neurodegenerative condition characterised by a prominent and progressive deterioration in language abilities, which significantly impacts quality of life and interpersonal relationships. Speech and language therapy plays a crucial role in offering interventions. Group intervention is one mode of delivery that could benefit communication functioning and overall wellbeing of people with PPA (pwPPA) and their care partners. Group interventions are also more efficient than one-to-one intervention and may facilitate peer support. The aim of this review was to systematically evaluate the current evidence for the effectiveness of speech and language therapy groups for pwPPA and their care partners. Specifically, this paper considered three questions: 1.What evidence-based speech and language therapy groups for pwPPA and their care partners have been reported to date? 2.Are group communication interventions effective in improving quality of life and communication function for pwPPA and their care partners? 3.Are group communication interventions that are designed for people with communication difficulties of other aetiologies (such as stroke) effective for pwPPA? In addition, this review aimed to describe the structure and content of groups, including aims, disciplines involved, size and frequency of group meetings, and outcome measures. MEDLINE, CINAHL and PsycINFO were used to retrieve articles of interest. A total of 10 studies published between 2009 and 2022 met the eligibility criteria and therefore were included in this study. Data were extracted from the articles regarding the structure and content of groups. Although evidence is currently limited, results suggest that speech and language therapy group intervention can improve specific linguistic processes, the use of communication strategies and psychosocial well-being. The importance of multidisciplinary input and care partners' involvement in groups was highlighted, along with the benefits of creative non-verbal activities as tools for self-expression. There is also initial evidence that telehealth group provision and one-off group sessions may be feasible and can benefit psychosocial well-being. Lastly, intentional recruitment and explicit education on different aphasia types are described as important when pwPPA participate in groups with mixed diagnoses. The literature on speech and language therapy group interventions for PPA shows promise of positive effects on communication function and psychosocial well-being of both pwPPA and their care partners. Speech and language therapists can consider these published interventions when designing and implementing similar groups, but more robust evidence is required to confirm the relative effectiveness of this approach. What is already known on this subject Speech pathology led group intervention shows some promise in benefitting communication functioning and overall well-being of pwPPA and their carers, but there has been no systematic evaluation of all the evidence regarding the efficacy of speech and language therapy led groups. Establishing feasibility, acceptability and efficacy of speech and language therapy group interventions for pwPPA and their carers may present a valuable addition for managing this progressive language disability. What this paper adds to existing knowledge Although evidence is currently limited, results from this systematic review suggest that speech and language therapy led group intervention can improve specific linguistic processes, the use of communication strategies and psychosocial well-being for pwPPA and their carers. The importance of multidisciplinary input and carers' involvement in groups was highlighted, along with the benefits of creative non-verbal activities as tools for self-expression. There is also initial evidence that telehealth group provision for carers may be feasible and can benefit psychosocial wellbeing. Lastly, intentional recruitment and explicit education on different aphasia types are described as important when pwPPA participate in groups with mixed diagnoses. What are the potential or actual clinical implications of this work? A synthesis of the evidence base for speech and language therapy led PPA groups, as well as a description of the group components and formats, will be valuable for clinical service planning, and will guide future examination of group options for pwPPA and their carers. Speech and language therapists can also consider the research findings from this systematic review when designing and implementing similar groups in their local context.

Profiling Communication Effectiveness in Persons with Aphasia in Aphasia Types

Communication problems caused by aphasia can negatively impact an individual’s ability to participate in society, and resume employment. The aim of the study was to assess various quality-of-life factors in person with aphasia and compare those factors between aphasia types. 20 (12 non-fluent; 8 fluent) Hindi-English bilingual Persons with Aphasia (PWA) were included in the study. Indian scale of Communicative effectiveness was administered to persons with aphasia. The tool consisted of various situations faced in day-to-day life. A comparison was obtained between aphasia types. Questions related to the generalization of skills acquired during therapy were taxing. Situations related to social involvement, speaking on the telephone, and communicating in various situations had an impact post-stroke. PWA faces challenges in communicating in the job environment. Persons with a fluent variant of aphasia have a lesser impact than the non-fluent type of aphasia. Hence, there is a need to work on the generalization of skills during management and considering the social context.

Demographic, Clinical and Language Characteristics of Malaysian Patients with Aphasia: A Retrospective Study

Limited research has been conducted in Malaysia on the characteristics of patients with aphasia. To address this gap, a retrospective study was conducted at Hospital Rehabilitasi Cheras (HRC). The study aimed to profile the demographic, clinical, and language characteristics of patients who underwent speech therapy for aphasia. Medical records from 2014 to 2017 were reviewed, focusing on 1,259 adult patients who were referred to the Speech Therapy Unit. Analysis included demographics, clinical aspects, and linguistic features. The Western Battery of Aphasia-Revised (WAB-R), a comprehensive assessment tool, was used to evaluate the language abilities. Among the patients' files analysed, a total of 211 contained WAB-R test results. The demographic profile revealed a higher proportion of male patients compared to females, with Malay patients comprising the majority, followed by Chinese and Indians. Age distribution included 41.7% older adults (aged 55 and above), 37.9% middle-aged (aged 36-55), and 20.4% younger adults (aged 18- 35). Notably, 44.5% had completed high school education. Clinically, right- sided hemiparesis was prevalent as noted with 67.8% of patients, while 14.7% had left-sided hemiparesis. The primary cause of aphasia was stroke, accounting for 71.1% of cases, with ischemic stroke being the dominant subtype (56.9%). Fluent aphasia was presented in 50.2% of the cases, compared to 49.3% of non-fluent aphasia. Anomic aphasia was the most common subtype (35.5%), followed by global aphasia (27.5%) and Broca’s aphasia (17.5%). The language profile provided a detailed description, encompassing linguistic aspects relevant to different aphasia types. These preliminary findings yielded valuable insights and hold significant implications for the clinical management of aphasia patients in Malaysia.

Exploring the association between social determinants and aphasia impairment: A retrospective data integration approach.

Traditionally, the study of aphasia focused on brain trauma, clinical biomarkers, and cognitive processes, rarely considering the social determinants of health. This study evaluates the relationship between aphasia impairment and demographic, socioeconomic, and contextual determinants among people with aphasia (PWA). PWA indexed within AphasiaBank-a database populated by multiple clinical aphasiology centers with standardized protocols characterizing language, neuropsychological functioning, and demographic information-were matched with respondents in the Medical Expenditure Panel Survey based on response year, age, sex, race, ethnicity, time post stroke, and mental health status. Generalized log-linear regression models with bootstrapped standard errors evaluated the association between scores on the Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) and demographic, economic, and contextual characteristics accounting for clustering of respondents and the stratification of data collection. Region, age, and income specific models tested the sensitivity of results. PWA over age 60 had 2.4% (SE = 0.020) lower WAB-R AQ scores compared with younger PWA. Compared to White PWA, Black and Hispanic PWA had 4.7% (SE = 0.03) and 0.81% (SE = 0.06) lower WAB-R AQ scores, respectively, as did those and living in the Southern US (-2.2%, SE = 0.03) even after controlling for age, family size, and aphasia type. Those living in larger families (β = 0.005, SE = 0.008), with income over $30,000 (β = 0.017, SE = 0.022), and a college degree (β = 0.030, SE = 0.035) had higher WAB-R AQ relative to their counterparts. Region-specific models showed that racial differences were only significant in the South and Midwest, while ethnic differences are only significant in the West. Sex differences only appeared in age-specific models. Racial and ethnic differences were not significant in the high-income group regression. These findings support evidence that circumstances in which individuals live, work, and age are significantly associated with their health outcomes including aphasia impairment.

Meta-analysis and systematic review of the relationship between sex and the risk or incidence of poststroke aphasia and its types

ObjectiveTo analyse and discuss the association of gender differences with the risk and incidence of poststroke aphasia (PSA) and its types, and to provide evidence-based guidance for the prevention and treatment of poststroke aphasia in clinical practice.Data sourcesEmbase, PubMed, Cochrane Library and Web of Science were searched from January 1, 2002, to December 1, 2023.Study selectionIncluding the total number of strokes, aphasia, the number of different sexes or the number of PSA corresponding to different sex.Data extractionStudies with missing data, aphasia caused by nonstroke and noncompliance with the requirements of literature types were excluded.Data synthesis36 papers were included, from 19 countries. The analysis of 168,259 patients with stroke and 31,058 patients with PSA showed that the risk of PSA was 1.23 times higher in female than in male (OR = 1.23, 95% CI = 1.19–1.29, P < 0.001), with a prevalence of PSA of 31% in men and 36% in women, and an overall prevalence of 34% (P < 0.001). Analysis of the risk of the different types of aphasia in 1,048 patients with PSA showed a high risk in females for global, broca and Wenicke aphasia, and a high risk in males for anomic, conductive and transcortical aphasia, which was not statistically significant by meta-analysis. The incidence of global aphasia (males vs. females, 29% vs. 32%) and broca aphasia (17% vs 19%) were higher in females, and anomic aphasia (19% vs 14%) was higher in males, which was statistically significant (P < 0.05).ConclusionsThere are gender differences in the incidence and types of PSA. The risk of PSA in female is higher than that in male.

Dissociating reading and auditory comprehension in persons with aphasia.

Language comprehension is often affected in individuals with post-stroke aphasia. However, deficits in auditory comprehension are not fully correlated with deficits in reading comprehension and the mechanisms underlying this dissociation remain unclear. This distinction is important for understanding language mechanisms, predicting long-term impairments and future development of treatment interventions. Using comprehensive auditory and reading measures from a large cohort of individuals with aphasia, we evaluated the relationship between aphasia type and reading comprehension impairments, the relationship between auditory versus reading comprehension deficits and the crucial neuroanatomy supporting the dissociation between post-stroke reading and auditory deficits. Scores from the Western Aphasia Battery-Revised from 70 participants with aphasia after a left-hemisphere stroke were utilized to evaluate both reading and auditory comprehension of linguistically equivalent stimuli. Repeated-measures and univariate ANOVA were used to assess the relationship between auditory comprehension and aphasia types and correlations were employed to test the relationship between reading and auditory comprehension deficits. Lesion-symptom mapping was used to determine the dissociation of crucial brain structures supporting reading comprehension deficits controlling for auditory deficits and vice versa. Participants with Broca's or global aphasia had the worst performance on reading comprehension. Auditory comprehension explained 26% of the variance in reading comprehension for sentence completion and 44% for following sequential commands. Controlling for auditory comprehension, worse reading comprehension performance was independently associated with damage to the inferior temporal gyrus, fusiform gyrus, posterior inferior temporal gyrus, inferior occipital gyrus, lingual gyrus and posterior thalamic radiation. Auditory and reading comprehension are only partly correlated in aphasia. Reading is an integral part of daily life and directly associated with quality of life and functional outcomes. This study demonstrated that reading performance is directly related to lesioned areas in the boundaries between visual association regions and ventral stream language areas. This behavioural and neuroanatomical dissociation provides information about the neurobiology of language and mechanisms for potential future treatment interventions.