Type B2 Research Articles

SAT555 Utility of 18F-DOPA PET/CT in the Diagnosis of Medullary Thyroid Cancer in a Patient with Multiple Endocrine Neoplasia Type 2B

Abstract Disclosure: D.G. Varghese: None. S. Akshintala: None. A. Jha: None. S. Gubbi: None. A. Reno: None. J. Klubo-Gwiezdzinska: None. K. Pacak: None. J. Glod: None. J. Del Rivero: None. Background: MEN2B is a cancer predisposition syndrome caused by an activating mutation in the RET proto-oncogene. It is characterized by medullary thyroid cancer (MTC), pheochromocytoma (PHEO), and extra endocrine features. U/S, CT, MRI and 18F-fluorodeoxyglucose (18F-FDG), 18F-fluorodihyroxyphenylalanine (18F-FDOPA), 68Ga-DOTA-(0)-Tyr(3)-octreotate (68Ga-DOTATATE) PET/CT scans have been used for the diagnosis and follow up of MTC. However, there is increasing evidence of 18F-FDOPA PET as more specific imaging modality in the diagnosis of MTC since L-type amino acid transporters have shown to be present in MTC cells.Clinical Case: 26-year-old female presented with HTN at the age of 17. The patient developed episodes of nausea/vomiting, intermittent headaches with systolic BP in the 190’s. Further work-up revealed bilateral adrenal nodules with elevated plasma metanephrines. The patient underwent left adrenalectomy and a year later, right adrenal nodule resection confirming PHEO. On follow up, calcitonin was elevated, and the patient underwent a total thyroidectomy with bilateral central lymph node dissection. At age 19 she was diagnosed with MEN2B (RET mutation, p.Met918Thr). With rising calcitonin, she was referred to our institution for further evaluation. Her serum calcitonin was 31986(<7.6 pg/ml), CEA 631 (0.8-3.4 ng/ml), fractionated plasma normetanephrine 565 (18-112 pg/ml), and metanephrine 304 (12-61 pg/mL). MRI of the abdomen showed enlarging adrenal masses. 18F-FDG PET/CT scan showed a focus of uptake (SUVmax of 8.5) in posterior right thyroid bed, uptake in the liver (SUVmax of 7.5) and uptake in the right adrenal gland and left adrenal bed; 68Ga-DOTATATE PET/CT scan showed a faint uptake in the right thyroid lobe (SUVmax of 2.7) and an 18F-FDOPA PET/CT scan showed intense uptake in both lobe of the thyroid, multiple lesions in the liver and suspicious focus in the right adrenal bed. The patient underwent bilateral adrenalectomy for recurrent PHEO and her plasma metanephrines normalized. Conclusion: This case adds to the mounting evidence in the usage of 18F-FDOPA PET/CT scan as a useful imaging modality for MTC especially in the setting of MEN2B syndrome. A head-to-head comparison in 18 patients, both per patient and per lesion sensitivity by 18F-FDOPA PET/CT (72%, 85%) was found to be statistically superior compared to 68Ga-DOTATATE PET/CT (33%, 20%), and 18F-FDG PET/CT (17%, 28%). A meta-analysis conducted in MTC consisting of 306 patients from 14 studies, 18F-FDOPA compared to 18F-FDG and 68Ga-DOTATATE showed the highest surface under the cumulative ranking curve (SUCRA) value in both patient and lesion-based analyses irrespective of serum calcitonin/CEA values or calcitonin doubling time. The potential for use of 18F-FDOPA as a diagnostic agent and the potential to provide insight into possible therapeutic targets are unknown and should be further studied. Presentation Date: Saturday, June 17, 2023

Intratracheal recurrence of thymoma 7 years after complete resection.

A 66-year-old woman with a massive anterior mediastinal tumour was diagnosed with type B2 thymoma. After 2 courses of chemotherapy, extended thymectomy and partial resection of the lung and large vessels were performed, and the tumour was completely resected. The patient received no postoperative therapy. Seven years after the surgery, follow-up chest computed tomography showed a papillary soft tissue tumour in the trachea almost obstructing the airway. Intratracheal tumour resection was performed under rigid bronchoscopy, and the pathological diagnosis of intratracheal recurrence of thymoma was made. The patient received postoperative radiotherapy and has remained alive without disease progression 9 months after the second operation.

Three-Dimensional Mapping of Chaput Tubercle Fractures: Evaluation of Morphologic Characteristics and Anterior Inferior Tibiofibular Ligament Involvement

Category: Ankle; Trauma Introduction/Purpose: Chaput tubercle fractures, which are thought to represent tibial-sided avulsions of the anterior inferior tibiofibular ligament (AITFL), are prevalent in up to 30% of trimalleolar ankle fractures. The optimal treatment of small Chaput avulsions is debatable; direct fixation with suture anchor devices and indirect (syndesmotic) fixation are considered as viable options, with proponents on both sides. Moreover, recent literature highlights the potential anatomical alterations to the incisura tibialis resulting from malreduction of large Chaput fragments, furthering the case for direct fixation. Hence, we performed a CT- based three-dimensional fracture mapping study to identify the morphological characteristics of these fractures, and to determine whether they consistently involve the AITFL, tibial plafond and incisura tibialis. Methods: This study included adult patients who had an ankle fracture with a Chaput component; the scheme described by Rammelt et al. was used to classify these fractures. CT scans were obtained, and 3D models were generated. The models were superimposed over a statistical shape model of the right tibia which served as a template and fracture lines were marked. The footprints of proximal and main bands of the AITFL and Basset’s ligament were also marked on the template tibia. The tibial template along with the fracture lines was then imported into MATLAB, and an automated script was used to determine the fragment size (length, breadth, and height), fracture surface area, involvement of the tibial plafond, tibial incisura, and the anterior inferior tibiofibular ligament (AITFL) and Basset’s ligament. Fracture maps and heat maps were generated. Agglomerative cluster analysis using Ward’s linkage was used to identify discrete fracture categories. Results: 76 patients, 21 males and 55 females were included in this study. Cluster analysis identified two distinct groups of fractures, each with two unique subgroups. We present this as a modification of the existing classification system. The first group, corresponded to Rammelt Type 1 fractures (sub centimetric extra-articular avulsion fractures, n=47). Of these, 19% (n=9) did not involve the AITFL, which we termed as Type 1a, and 91% (n=48) involved the AITFL, which we termed as Type 1b. The second group consisted of large intra-articular fractures that corresponded to Rammelt Type 2 injuries. Of these 23% (n=6) involved only the incisura, which we termed as Type 2a; 77 % involved both the incisura and the tibial plafond and were termed as Type 2b. Conclusion: We propose a modification of the existing classification of Chaput fractures on the basis of quantitative fracture mapping. This study provides new insights into the morphological characteristics of Chaput fractures. 19% of small Chaput fractures do not involve the AITFL and may not require direct fixation. Conversely, all large-sized fragments involve the incisura and necessitate anatomical reduction to achieve accurate syndesmotic reduction. Our proposed modification can aid in surgical decision-making, particularly in choosing between direct and indirect syndesmotic fixation.

Morphological Analysis of Intraarticular Fragments in AO/OTA 44 Category Posterior Malleolar Fractures

Category: Ankle; Trauma Introduction/Purpose: Intraarticular fragments (IAFs) associated with posterior malleolar fractures are a major obstacle in the treatment of ankle fractures. However, their frequency, location, and morphology, as well as their relationship with the classification of ankle posterior malleolar fractures, are poorly understood and unresolved. The Purpose of this study is to clarify the frequency and morphology of IAFs in posterior malleolar ankle fractures. Methods: This study was conducted at a single institution and included 104 consecutive patients with trimalleolar ankle fractures treated between 2015 and 2022. The inclusion criteria were 1) acute fracture within 2 weeks after injury and 2) cases with computed tomography (CT) images at the time of injury. The exclusion criteria were 1) previous ipsilateral ankle fracture, 2) pathological fracture, and 3) younger age with open physis. CT images at the time of injury were reviewed and each posterior malleolar fracture was classified using the Mason classification. Frequency of occurrence, size (long diameter × short diameter), and angle (the angle between the long diameter and fracture surface of the posterior malleolar fracture) of the IAF. The location of the IAF was described from CT axial images The dislocated distance of the IAF from the articular surface was measured on the sagittal CT view. Results: The patient’s mean age was 54.6 years. 46 cases were Type 1, 32 cases were Type 2A, 9 cases were Type 2B, and 17 cases were Type 3 according to the Mason’s classification. In Mason Type 2 and 3 cases, the IAF was present in 32 (78.0%) and 12 (70.6%) cases, respectively. The IAF was more frequently observed laterally in type 2 (22 cases) and medially in type 3 (7 cases). The long × short diameter of the IAF averaged 11.2 × 4.9 mm and 9.0 × 3.7 mm for Types 2 and 3, respectively. The angle of IAF was 10.5 ± 13.4° and 8.5 ± 7.8°, the distance of displacement was 3.0 ± 2.6 mm and 2.4 ± 1.2 mm, respectively. Conclusion: This study revealed a high incidence of IAFs in posterior malleolar ankle fractures. The IAF has a long medial to lateral shape, as well as the direction of the posterior malleolus fracture, occurs more often laterally in Mason Type 2 and medially in type 3. These findings suggest a pathophysiology in which the axial force causes secondary intraarticular impingement after the main fracture of the posterior malleolus. resulting in the development of an IAF. Handling IAFs is one of the keys in the treatment of posterior malleolar fractures and the surgical approach should be also selected based on the IAF.

Theoretical Investigation of Pressure Dependent Structural and Elastic Properties of MnSi Compound

MnSi is a metallic compound that exhibits a structural phase transition as a function of pressure. At ambient conditions, MnSi has a cubic structure such as NaCl type crystal structure. However, at high pressures, it undergoes a structural phase transition to a CsCl type crystal structure. The pressure-dependent structural phase transition in MnSi has been studied using various experimental and theoretical techniques. In the present work, we have used an efficient inter-ionic potential approach to predict pressure dependent structural phase change and associated volume collapse in MnSi. Therein, the potential includes the long-range Coulomb, van der Waals (vdW) interaction, and the short-range repulsive interaction up to second neighbour ions. It has been demonstrated that the Hafemeister and Flygare approach successfully evaluates the equation of state for change in volume with respect to applied pressure. We have identified a structural phase transition from B1(NaCl) type structure to B2 (CsCl) type structure in this compound. The estimated value of phase transition pressure (Pt) is 42 GPa, which is consistent with the available reported data. The identified first order phase transformation showed a volume collapse of about 10% in the vicinity of transition. In addition, we have also investigated second order of elastic constants for MnSi compound.

Incongruity of the scapulohumeral arch: an indirect sign of posterior subluxation of the humeral head in primary glenohumeral osteoarthritis.

In symptomatic glenohumeral osteoarthritis, arthroplasty is the gold standard to restore a mobile and painless shoulder. The kind of arthroplasty chosen is based mainly on the evaluation of the rotator cuff and the type of glenoid. The aim of this study was to analyze the scapulohumeral arch in primary glenohumeral osteoarthritis (PGHOA) with a non-injured cuff and to determine whether posterior humeral subluxation influences Moloney's line, which corresponds to an intact scapulohumeral arch. Between 2017 and 2020, 58 anatomic total shoulder arthroplasties were implanted in the same center. We included all patients with complete preoperative imaging (X-rays and MRI or arthro-CT scan) assessing an intact rotator cuff. A total of 55 shoulders that had undergone surgery for a total anatomical shoulder prosthesis were analyzed after determining the type of glenoid in the frontal plane according to the Favard classification on an anteroposterior X-ray and in the axial plane according to the Walch classification on CT scan. The grade of osteoarthritis was evaluated according to Samilson. We analyzed whether there was a rupture of Moloney's line on the frontal radiograph and assessed the acromiohumeral distance. After preoperative analysis of 55 shoulders, 24 shoulders had a type A glenoid and 31 a type B glenoid. Twenty-two shoulders had a scapulohumeral arch rupture and 31 had a posterior subluxation of the humeral head: 25 shoulders had a type B1 glenoid and 6 had a type B2 glenoid according to the Walch classification. Most glenoids were E0 (n=47, 85%). The incongruity of Moloney's line was more frequent with type B than A glenoids (20/31, 65%, vs 2/24, 8%, p<0.001). No patient (0/15) with a type A1 glenoid had rupture of Moloney's line, and only two patients (2/9) with a type A2 glenoid had incongruency of the scapulohumeral arch. In PGHOA, the rupture of the scapulohumeral arch seen in anteroposterior X-rays, also known as Moloney's line, may be an indirect sign of posterior humeral subluxation, corresponding to a type B glenoid in the Walch classification. Incongruity of Moloney's line may indicate a rotator cuff injury or posterior glenohumeral subluxation with an intact cuff in PGHOA.

International expert consensus on the surgical anatomic classification of radical hysterectomies

The anatomic descriptions and extents of radical hysterectomy often vary across the literature and operative reports worldwide. The same nomenclature is often used to describe varying procedures, and different nomenclature is often used to describe the same procedure despite the availability of guideline and classification systems. This makes it difficult to interpret retrospective surgical reports, analyze surgical databases, understand technique descriptions, and interpret the findings of surgical studies. In collaboration with international experts in gynecologic oncology, the purpose of this study was to establish a consensus in defining and interpreting the 2017 updated Querleu-Morrow classification of radical hysterectomies. The anatomic templates of type A, B, and C radical hysterectomy were documented through a set of 13 images taken at the time of cadaver dissection. An online survey related to radical hysterectomy nomenclature and definitions or descriptions of the associated procedures was circulated among international experts in radical hysterectomy. A 3-step modified Delphi method was used to establish consensus. Image legends were amended according to the experts' responses and then redistributed as part of a second round of the survey. Consensus was defined by a yes response to a question concerning a specific image. Anyone who responded no to a question was welcome to comment and provide justification. A final set of images and legends were compiled to anatomically illustrate and define or describe a lateral, ventral, and dorsal excision of the tissues surrounding the cervix. In total, there were 13 questions to review, and 29 experts completed the whole process. Final consensus exceeded 90% for all questions except 1 (86%). Questions with relatively lower consensus rates concerned the definitions of types A and B2 radical hysterectomy, which were the main innovations of the 2017 updated version of the 2008 Querleu-Morrow classification. Questions with the highest consensus rates concerned the definitions of types B1 and C, which are the most frequently performed radical hysterectomies. The 2017 version of the Querleu-Morrow classification proved to be a robust tool for defining and describing the extent of radical hysterectomies with a high level of consensus among international experts in gynecologic oncology. Knowledge and implementation of the exact definitions of hysterectomy radicality are imperative in clinical practice and clinical research.

B chromosomes in Conifers (Study Case of the Genus Picea A. Dietr.)

Data on B chromosomes in the genus Picea (Spruce) species are presented. Species of this genus are good objects for studying many problems on the role and origin of supernumerary chromosomes in conifers. Classical methods for studying chromosomes with staining of preparations with acetohematoxylin and the method of fluorescent in situ hybridization (FISH) were used. We report the B chromosomes occurrence in five Picea species and confirmed the data of different authors for seven species. At present, supernumerary chromosomes are found in 23 Picea species including the interspecies hybrid P. × fennica. B chromosomes of Picea species are smaller than A chromosomes; their size (4-6 µm) is 25-30% of the size of A chromosomes. The B chromosomes of spruce species are either meta- or submetacentric, which have been designated as B1 and B2 types respectively. The number of B chromosomes per cell in spruce species varies from one to six. It is generally agreed that B chromosomes are derived from A chromosomes through chromosome arrangements They differ from A chromosomes in sequence composition. The results allow us to consider that B chromosomes are of importance for organisms and possibly may play a role in their adaptation.

The Value of Postoperative Radiotherapy in Thymoma with Myasthenia Gravis

For patients with thymoma combined with myasthenia gravis (MG), surgery is the first-line treatment. However, there is still debate on the effects of radiotherapy among these patients. This study is aimed to investigate the efficacy and prognosis of postoperative radiotherapy (PORT) on thymoma patients with MG. This retrospective cohort study included 126 patients with MG and thymoma from 2011 to 2021. Demographic data and information that were collected included sex, age, histologic subtype, Masaoka-Koga staging, the primary tumor, lymph node, and metastasis (TNM) staging and therapy modalities. Changes in the Quantitative Myasthenia Gravis Score (QMGs) within 3 months after treatment were used to evaluate the short-term MG symptom improvement after PORT. Minimal manifestation status (MMS) was the main endpoint of assessing the long-term MG symptom improvement. Overall survival (OS) and disease-free survival (DFS) were the primary endpoints for PORT in prognosis. Effects of PORT on MG symptom: there was a significant difference in QMG scores between non-PORT and PORT groups (χ2 = 6.300, p = 0.012). The median time to achieve MMS of patients in the PORT group was significantly shorter when compared with the non-PORT group (2.0 years versus 4.4 years [p = 0.031]). Multivariate analysis demonstrated that radiotherapy was associated with a shorter time to achieve MMS (HR 1.971, 95% CI:1.102-3.525, p = 0.022). Effects of PORT on DFS and OS: the 10-year OS rate of the whole cohort was 90.5%. The OS rates of the PORT group and the non-PORT group were 94.4% and 85.1% respectively. The 5-year DFS rates in the whole cohort, PORT group, and non-PORT group were 89.7%, 95.8%%, and 81.5%, respectively. PORT was associated with improved DFS (HR 0.139, 95% CI: 0.037-0.533, p = 0.004). In the high-risk histologic subgroup (type B2, B3), PORT exhibited better survival than non-PORT in OS (p = 0.015) and DFS (p = 0.0053). PORT remained associated with improved DFS (HR 0.232, 95% CI: 0.069-0.782, p = 0.018) in Masaoka-Koga staging II, III, and IV disease. The efficacy of PORT in patients with thymoma and MG is positive. Patients in the higher histologic subtype and Masaoka-Koga staging may benefit more obviously.

A comparative study on the clinical efficacy of microplate trans-carpometacarpal joint fixation and non-trans-carpometacarpal joint fixation in treating fractures with dislocation or subluxation of the base of the fourth and fifth metacarpal bones

BackgroundThis study aimed to compare the clinical efficacy of microplate trans-carpometacarpal joint fixation and non-trans-carpometacarpal joint fixation in treating fractures and dislocation or subluxation of the base of the fourth and fifth metacarpal bones.MethodFrom 2015 to 2021, 100 cases of metacarpal basal fractures with dislocation or subluxation were randomly divided into the trans-carpometacarpal joint fixation group (group A) and non-trans-carpometacarpal joint fixation group (group B). Group A (n = 50) comprised 44 males and 6 females, with an average age of 28.8 ± 6.1 y and an Orthopedic Trauma Association (OTA) fracture classification of type B1 (n = 29) or C1 (n = 21). Group B (n = 50) comprised 45 males and 5 females, with an average age of 28.9 ± 5.7 y and an OTA fracture classification of type B1 (n = 28) or C1 (n = 22). All patients were complicated with dislocation or subluxation. The surgery time, fracture healing time, postoperative handgrip strength, and total active motion (TAM) scores of the ring and little fingers were recorded and compared between the two groups. The clinical efficacy of patients was evaluated using scoring methods such as DASH (disabilities of the arm, shoulder and hand), visual analogue scale (VAS), and Mayo at 3, 6, and 12 months after surgery.ResultsThere was no significant difference in the general indexes, surgery time, or fracture healing time between the two groups (P > 0.05). There were no significant differences in handgrip strength and TAM scores of the ring and little fingers between the two groups at 3 and 12 months postoperatively (P > 0.05), but there were significant differences in these indexes 6 months postoperatively (P < 0.05). There were no significant differences in the DASH, VAS, and Mayo scores at 3 and 12 months postoperatively (P > 0.05), but there were significant differences between the two groups in the DASH and Mayo scores (P < 0.05) but not the VAS score (P > 0.05) 6 months postoperatively.ConclusionIn the treatment of fourth and fifth metacarpal basal fractures with dislocation or subluxation, both microplate transarticular fixation and non-transarticular fixation could achieve fracture fixation and healing, and each method had advantages and disadvantages. The clinically appropriate fixation method should be selected according to the experience of the surgeon and the degree and type of fracture and dislocation.

Prevalence of Ankle Charcot Neuroarthropathy Presenting in a Tertiary Care Center

Charcot neuroarthropathy's (CN) anatomic classification was originally formulated by the Brodsky article and the Trepman et al modification, including midfoot (type 1), rearfoot (type 2), ankle (type 3a), calcaneus (type 3b), multiarticular (type 4), and forefoot (type 5). In these classic studies, ankle joint and multijoint CN are reported as 9% and 6% to 9%, respectively, but we believe ankle CN to be more common than that in a tertiary setting. We retrospectively reviewed patients presenting initially or as referral between 2004 and 2020. Initial presentation radiographs were reviewed and classified by 3 authors based on Brodsky's model with Trepman and colleagues' modification, and any discrepancies were reviewed by the fourth author. A total of 175 patients (205 feet) were assessed. This revealed 80 cases classified as type 1 (39.0%), 23 cases type 2 (11.2%), 17 cases type 3a (8.3%), 2 cases type 3b (1.0%), and 83 cases type 4 (40.5%). After subdividing type 4, total prevalence included 150 with type 1 anatomic location (73.2%), 103 type 2 (50.2%), 44 type 3a (21.5%), and still 2 type 3b (1.0%). This study revealed a similar prevalence of isolated ankle CN (8.5%) compared to the Trepman et al article (9%), however, in total, ankle CN (21.5%) occurred 2.4-times more than the original 9%. Our study also found there to be a higher prevalence of ankle CN in the setting of multiarticular CN, which has not been evaluated in past studies. The prevalence of multiarticular CN was found to be 4.5-fold greater than the Trepman article (6%-9%).

Diagnostic Performance of Belly-Press Angle in Predicting the Severity of Subscapularis Tear

Background: Neglected partial subscapularis tears often cause functional impairment even after repair of the supraspinatus and infraspinatus tear is done. Numerous physical examinations for detecting partial subscapularis tears have been described in previous studies. Purpose: To analyze the relationship between the preoperative clinical features and the severity of a partial subscapularis tear and to provide diagnostic clues for patients requiring subscapularis repair. Study Design: Cohort study (Diagnosis); Level of evidence, 2. Methods: This retrospective study included 286 patients who underwent arthroscopic shoulder surgery between 2020 and 2022. Preoperative clinical features, including range of motion, functional scores, muscle strength ratio, modified belly-press test (measuring belly-press angle), and bear-hug test, were collected. Magnetic resonance imaging (MRI) evaluation was done according to the Yoo and Rhee classification. Types of subscapularis tear, supraspinatus lesion, and biceps lesion were recorded during arthroscopic surgery. A comparison of preoperative clinical features between the no-repair group (type 2A or less) and surgical repair group (type 2B or more) was done. The optimal cutoff value of the belly-press angle was determined and the diagnostic performance of the belly-press angle, bear-hug test, and MRI were evaluated using the receiver operating characteristic curve. Results: Among 286 patients, 189 (66.1%) had subscapularis tears with type 2A or more. There was a significant difference in muscle strength ratio of the belly-press (P < .001), belly-press angle (P < .001), and bear-hug test (P < .001) between the no-repair group (type 2A or less) and the surgical repair group (type 2B or more). With a belly-press angle of 15° as a new cutoff value, the modified belly-press test showed 67.6% sensitivity, 73.9% specificity, and 69.6% accuracy in detecting type 2B or higher subscapularis tear. Conclusion: Patients with type 2A and 2B subscapularis tears (according to the Yoo and Rhee classification) showed differences in belly-press strength ratio, belly-press angle, and bear-hug test. The cutoff value of the 15° belly-press angle showed an accuracy of 69.6% in detecting subscapularis tears with type 2B or higher.

Simultaneous occurrence of type 3b esophageal atresia and hypertrophic pyloric stenosis: A rare coexistence

Background: Hypertrophic pyloric stenosis (HPS) and Esophageal Atresia (EA) are two distinct congenital malformations that rarely occur simultaneously. However, there have been reported cases of the simultaneous occurrence of HPS and EA, suggesting a potential relationship between these two conditions. The clinical features of the simultaneous occurrence of HPS and EA can be modified and the diagnosis may be delayed. Case presentation: We present a rare case of a newborn with simultaneous Type 3b esophageal atresia and hypertrophic pyloric stenosis. Following surgical correction of esophageal atresia, the patient exhibited symptoms of projectile vomiting, which were subsequently confirmed through ultrasound examination to be associated with hypertrophic pyloric stenosis. The patient was successfully managed through surgical intervention, and the outcomes were favorable. Conclusion: This case report aims to highlight the significance of preoperative screening for hypertrophic pyloric stenosis in patients diagnosed with esophageal atresia, based on current literature.

The maximal contrast-enhanced range of CT for differentiating the WHO pathological subtypes and risk subgroups of thymic epithelial tumors.

To explore the value of maximal contrast-enhanced (CEmax) range using contrast-enhanced CT (CECT) imaging in differentiating the pathological subtypes and risk subgroups of thymic epithelial tumors (TETs). The pre-treatment-CECT images of 319 TET patients from May 2012 to November 2021 were analyzed retrospectively. The CEmax was defined as the maximum difference between the CT value of the solid tumor on pre-contrast and contrast-enhanced images. The mean CEmax value was calculated at three different tumor levels. There was a significant difference in the CEmax among the eight main pathological subtypes [types A, AB, B1, B2, and B3 thymoma, thymic carcinoma (TC), low-grade neuroendocrine tumor (NET) and high-grade NET] (p < 0.001). Among the eight subtypes, the CEmax values of types A, AB, and low-risk NET were higher than those of the other subtypes (all p < 0.001), and there was no difference among types B1-B3 and high-risk NET (all p > 0.05). There was no difference for CEmax values between NET and TC (p = 0.491). For the risk subgroups, the CEmax of TC (including NET) was 35.35 ± 11.41 HU, which was lower than that of low-risk thymoma (A and AB) (57.73±21.24 HU) (P < 0.001) and was higher than that of high-risk thymoma (B1-B3) (27.37±8.27 HU) (P < 0.001). The CEmax cut-off values were 38.5 HU and 30.5 HU respectively (AUC: 0.829 and 0.712; accuracy, 72.4% and 67.7%). The tumor CEmax on CECT helps differentiate the pathological subtypes and risk subgroups of TETs. In this study, an improved simplified risk grouping method was proposed based on the traditional (2004 edition) simplified risk grouping method for TETs. If Type B1 thymoma is classified as high-risk, radiologists using this improved method may improve the accuracy in differentiating risk level of TETs compared with the traditional method.

Preoperative spontaneous regression of type B2 thymoma in a patient with myasthenia gravis

Thymoma is the most common tumor of the anterior mediastinum. Spontaneous regression of thymoma is extremely rare. A 34-year-old female patient without any known disease, admitted by a myasthenic crisis, had a mass of 76 x 53 x 88 mm on thorax computed tomography (CT). The patient received intravenous immunoglobulin (IVIg) treatment for 5 days, pyridostigmine 60 mg/8 hours and prednisone 30 mg/day for the treatment of myasthenic crisis. Thorax CT on the 18th day showed that the mediastinal mass regressed to 63 x 30 x 63 mm. Histopathological analysis after extended thymectomy revealed the diagnosis of type B2 thymoma.

Functional outcome of intramedullary nailing of the femoral shaft fracture

Background &amp; Objective: A common fracture is a femoral shaft fracture. The advantages of intramedullary interlocking nails make them the method of choice for treating femoral shaft fractures. These benefits include a small incision, minimal dissection, decreased rates of infection, nonunion, and malunion, shorter hospital stays and rehabilitation periods, excellent union, rotational stability and length maintenance, rapid recovery, and early weight-bearing. Therefore, the aim of this study was to analyze the functional findings from femoral shaft fracture intramedullary nailing. Material and Methods: This was a hospital- based, longitudinal, observational study. All patients with femoral shaft fractures admitted at UCMS-TH, Bhairahawa from the Emergency Department managed surgically from October 2019 to March 2020 were included in the study. Femoral shaft fractures with age ≥ 16 years were included while open fractures (Gustalio and Anderson type 2 and 3), pathological fractures,congenital anomaly of the affected limb, previous fracture of the affected limb were excluded. All the patients were managed surgically and followed for at least 6 months. The outcome was measured by the Thoresen scoring system at the end of 6 months. Results: In this study of 30 cases, the mean age was 30.47 years, male and female ratio of 2:1, the left side was affected in 18 cases, RTA was the most common mode of injury. Most of the cases were Winquist and Hansen type 2 and AO type 32B. In the majority of the cases, 27 cases (90%) had no complication while superficial infection in 2 cases and shortening was seen in 1 case. We found excellent results in 86.7% cases, good in 10% cases and fair in 3.3% cases. Conclusion: The excellent functional outcome in terms of alignment and range of motion obtained in this study in the majority of patients makes this technique more reliable. The method of choice for femoral shaft fracture in adults was due to its low complication rate, high incidence of union, shorter hospital stay and early mobility.

Morphological analysis and classification of posterior malleolar fractures based on CT scans

ObjectivesThe aim of the study was to propose a classification system of posterior malleolar fractures by fracture lines with the use of CT scans, including 3D CT reconstruction, which can better understand morphological characteristics, analyze the mechanism and guide the surgeon to choose the optimal approach and fixation. MethodsPatients with OTA/AO type 44 fractures involving the posterior malleolus and preoperative CT scans were included. We retrospectively analyzed 128 consecutive patients with posterior malleolar fractures from January 2013 to December 2019 at our institution. CT data were loaded into Mimics software (V20.0, Materialize), in which 3D CT reconstruction, morphological analysis and data measurements were made. ResultsBased on the number of fracture lines in 128 consecutive patients, posterior malleolar fractures were classified into three types: type 1 with a single fracture line, type 2 with double fracture lines and type 3 with multiple fracture lines. According to the distribution of the fracture line, type 1 was divided into types 1A, 1B and 1C, and type 2 was divided into types 2A, 2B and 2C. The fracture line from the fibular notch to the posterior rim of the distal tibia was defined as type 1A, and the fracture line to the medial malleolus was defined as type 1B. Type 1C was a small fragment in the posterior rim of the distal tibia. Type 2A was regarded as type 1A with type 1C. It was considered type 2B because another fracture line started from the fracture line of type 1A and extended to the medial malleolus. In type 2C, we could see that the double fracture lines were all from the fibular notch to the posterior rim of the distal tibia and did not cross. Type 3 fractures were comminuted fractures with multiple fracture lines. ConclusionThe morphology of posterior malleolar fractures, involvement of the fibular notch, or the medial malleolus can be obviously assessed by our classification system. We found the relation of the injury mechanism between type 1 and type 2 by comparing the area of the fragment. We have indicated that each type of fracture corresponds to its associated injury mechanism and which surgical approach and fixation can be chosen.

Development of Recycled Air-filled PET Bottle Blocks for Cavity Wall Construction

This study examines the prospect of using PET bottles in mortar block for cavity wall construction in respect of compressive strength and cost. 500-mL air-filled waste plastic bottles encased by mortar plaster worked as the voids in the masonry units. Three different type of blocks B1, B2, B3 were prepared with the cement sand proportion 1:3, 1:3.5 and 1:4 respectively. Result shows that the strength decreased with the reduction of the proportion of cement. The maximum compressive strength found in B1which was 5.21 MPa after 7 days and 9.29 after 28 days of curing. B2 and B3 also shows 74% and 71% increase in strength as they reach the curing age of 28 days. The comparison of cost for wall construction with both bottle block and hollow concrete block shows, for external wall, the material cost can be reduced by 27% in the case of bottle block. So it can be used as a sustainable alternative of hollow concrete blocks in terms of strength and cost for cavity wall construction and have a great effect on plastic waste management. Key Words: Waste PET Bottles, Hollow Block, Compressive strength, Cost analysis.

Fracture pattern and risk factors for reoperation after treatment of 156 periprosthetic fractures around an anatomic cemented hip stem.

The Lubinus SP2 stem has been associated with a very low risk of periprosthetic femoral fractures (PPFFs). We aimed, primarily, to study the radiographic morphology of PPFFs close to a Lubinus SP2 stem. Secondarily, we analyzed whether higher reoperation rate was correlated to the revision method chosen or to the characteristics of the fracture and of the bone. The study included 156 femoral fractures close to a Lubinus cemented stem. These fractures were treated in 40 hospitals in Sweden between 2006 and 2011 and were followed up until 2019. Data from the Swedish Arthroplasty Register was used. Medical records and radiographs were studied. The fractures were classified according to the Vancouver classification. The fracture location and anatomy were delineated. We also measured the remaining attachment index (RAI) and the canal thickness ratio. Vancouver type C (n = 101) and spiral fractures (n = 67, 41 in Vancouver C and 26 in Vancouver B) were the most common fracture types. 4 fractures were avulsion of the greater trochanter. The remaining 51 fractures occurred around the stem (B1: 25, B2: 16, and B3: 10). B fractures were more commonly reoperated on (18 of 51, 35%) than type C fractures (11 of 101, 11%, P = 0.001). In most femurs with type B3 fracture, the fracture line covered an area only around the stem, but in all B1 and in 11 of 16 B2 fractures, it was extended even distal to the stem. ORIF instead of stem revision in B2 fractures, use of short stems or plates, and inadequate reduction of the fractures were risk factors for subsequent reoperations. The higher reoperation rate in type B fractures, compared with fractures distal to the stem, could be caused by their higher degree of complexity and reduced capacity for healing in the region around the stem.

Use of locked plates and mono-rail fixator in segmental tibial defects: A prospective interventional study

IntroductionThe management of gap non-union is a major challenge to both the clinician and the patient as it is technically difficult, time-intensive, and physically arduous for the patient along with an unpredictable result. Gap non-union can arise from extrusion of bony fragment at the time of trauma or after debridement of unhealthy bone later. Moreover, Tibia because of its subcutaneous anatomy can easily undergo bone-loss and segmental defect. Among various methods available for managing gap non-union of tibia distraction osteogenesis using either ilizarov fixator or mono-rail fixator is the most popular one. Here we present functional and bony outcomes of combined use of locking plate and Limb Reconstruction System (LRS) in tibial gap non-union and assess whether it decreases fixator time and related complications. Patients and methodsA prospective intervention study constituting 10 patients with Paley's type B1 tibial gap non-union over a period of 22months. In first stage, debridement was done; tibial locking plate and mono-rail fixator were applied along with corticomy at proximal tibia. Distraction was started 7–14 days later. At the end of distraction phase, fixator was removed and transported segment was fixed with screws with or without bone grafting at docking site. Patients were followed up every 6 weeks for radiological and clinical assessment. Functional assessment using Application for the Study and Application of the Method of Ilizarov (ASAMI) functional score, and Musculoskeletal Tumour Society (MSTS) functional score while bone outcome was assessed with ASAMI bone score. Quality of regenerate was assessed by Fernandez-Esteve grading. Detailed scoring was done at the time of index surgery, at the time of LRS removal and at the time of consolidation phase. ResultsAll the 10 patients were male with mean age of 33 years. The mean defect size was 4.94 cm after debridement. Minimum duration of follow up was 30 weeks after removal of LRS. Mean duration between trauma and inclusion in the study was 17.7 months. The median external fixator index was 15.63 days/cm. The complication rate was 1.3/patient. According to Paley's classification, there were eleven problems and two obstacles, and no true complications. Both ASAMI bone score and functional scores were excellent in three and good in six patients. The median MSTS composite score was 76.66%. ConclusionThe integrated fixation is an effective and satisfactory method enabling early external fixator removal with low rate of complication. So, this technique can be recommended for the management of segmental tibial defects. Level of evidenceII.