The article deals with experimental and numerical research of the layered reinforced concrete slab with plastic inserts. The investigated layered reinforced concrete slab is made of prefabricated and monolithic reinforced concrete layers. Voids were formed in the plate with spherical plastic inserts. With reference to the built-up bars theory, the paper proposes an analytical method for calculating the deflection of the layered reinforced concrete structures in non-linear stage, when bond between layers is partially rigid. The article also focuses on the numerical simulation of the layered slab, compares the estimated theoretical values of deflection with the experimental values and assesses the shear stiffness of the bond of prefabricated and monolithic concrete layers for calculating the deflection of the reinforced concrete slab. Paper presents the parametric analysis of deflection dependence on shear stiffness and the width of the contact zone of the layers. It was established that proposed analytical method and numerical analysis properly characterise the behaviour of the slab. Calculation results were close to experimental data. Moreover, it was determined that performance of this type of slab is highly influenced by shear stiffness of the bond between the concrete layers. Analysis confirmed that slab fails when bond is damaged, and layers slip in the support zone.