Type Of Study Design Research Articles

In dogs with osteoarthritis, is intra-articular allogenic mesenchymal stem cell therapy more effective than placebo effect?

PICO question
 In dogs diagnosed with osteoarthritis in the hip, elbow, stifle or shoulder joint, is treatment with intra-articular allogenic mesenchymal stem cell therapy, in comparison with a placebo effect, more effective at reducing lameness and pain?
 
 Clinical bottom line
 Category of research question
 Treatment
 The number and type of study designs reviewed
 All three papers were randomised controlled trials
 Strength of evidence
 Weak
 Outcomes reported
 Intra-articular allogenic stem cell therapy is effective at reducing pain and lameness in dogs with osteoarthritis when compared to a placebo effect. Two studies indicated a statistically significant improvement in both client and veterinary outcome measurements. Client outcome measurements utilised included: the canine brief pain inventory; a measure of any changes in pain and lameness based on owners perception, and the client-specific outcome measure; and an evaluation of the impact of osteoarthritis on three client selected activities and how this changed with treatment. Veterinary outcome measurements included veterinary pain score based on manipulation of the limb, veterinary assessment of clinical outcomes and veterinary pre and post lameness examinations, all of which were subjective measures.
 The final study identified a statistically significant improvement in both pain and lameness based on owner assessments utilising the canine brief pain inventory and the Hudson Visual Analogue Scale for lameness scoring. No statistically significant improvement was identified when considering subjective and objective veterinary measurements including force plate gait analysis and veterinary orthopaedic examination
 Conclusion
 There is moderate evidence from owner observation and veterinary assessment to suggest that intra-articular allogenic (adipose and umbilical derived) stem cell therapy has some efficacy for reducing pain and lameness compared to a placebo effect. However, it must be noted that these studies did not compare the use of intra-articular allogenic stem cells with conventional treatments such as intra-articular corticosteroid injections. Therefore, comparison trials are required.
 Whilst all three papers showed significant improvements in the subjective measurements, objective data outcomes and assessment by board certified veterinary surgeons failed to find a significant improvement in peak vertebral force or lameness with the use of intra-articular stem cell therapy in comparison to a placebo effect. Furthermore, whilst no significant adverse reactions to intra-articular stem cell therapy were recorded, information regarding the safety for multiple dosing is lacking and ambiguity remains as to the most appropriate lineage and quantity of allogenic stem cells for the best clinical effect
 
 How to apply this evidence in practice
 The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
 Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
 

Does trazodone reduce anaesthetic agent requirement in dogs?

PICO question
 In dogs undergoing anaesthesia, does the use of oral trazodone given 2 hours before induction of anaesthesia reduce injectable or inhalant anaesthetic agent requirements?
 
 Clinical bottom line
 Category of research question
 Treatment
 The number and type of study designs reviewed
 Two randomised controlled trials were critically appraised
 Strength of evidence
 Moderate
 Outcomes reported
 Trazodone was shown to have a significant isoflurane minimum alveolar concentration (MAC) sparing effect for isoflurane. There is also evidence to suggest trazodone has a similar effect on the cardiovascular system as acepromazine
 Conclusion
 Trazodone should be considered as part of a multimodal approach to anaesthesia in dogs to reduce the injectable and inhalant anaesthetic agent requirements
 
 How to apply this evidence in practice
 The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
 Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
 

Nursing, frailty, functional decline and models of care in relation to older people receiving long-term care: a scoping review protocol

IntroductionOlder people receiving healthcare in long-term care contexts (eg, home healthcare, sheltered housing and nursing home contexts) are especially vulnerable to developing frailty and functional decline. Considering the negative effects...

An assessment of client and clinician satisfaction in veterinary teleconsultation compared to in-person consultations

PICO question
 Compared to in-person veterinary consultations, does teleconsultation lead to similar levels of client and clinician satisfaction?
 
 Clinical bottom line
 Category of research question
 Qualitative assessment
 The number and type of study designs reviewed
 Eight studies were critically appraised. There were six cross-sectional studies, one randomised controlled clinical trial, and one case report
 Strength of evidence
 Weak
 Outcomes reported
 All eight studies provided weak evidence of similar levels of clinician and / or client satisfaction
 Conclusion
 Teleconsultation can lead to similar levels of client and clinician satisfaction when compared to in-person consultations. However, the evidence is weak due to the subjectivity and varied methods of measuring satisfaction. Furthermore, the current applicability of veterinary teleconsultation is still very limited to certain select scenarios in which it is appropriate (e.g., emergency, triage, remote locations, non-complicated routine postoperative checks, nutrition and behavioural consults)
 
 How to apply this evidence in practice
 The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
 Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
 

Can straw based enrichment treat tail biting in pigs?

PICO question
 Can straw based enrichment be used successfully as a treatment intervention to reduce tail biting injuries in weaner to finisher pigs housed in indoor farming systems?
 
 Clinical bottom line
 Category of research question
 Treatment
 The number and type of study designs reviewed
 Three papers were critically reviewed. All three papers answered the PICO question and matched the inclusion criteria for this Knowledge Summary, providing moderate evidence. One non-randomised controlled trial and two randomised controlled trials.
 Strength of evidence
 Moderate
 Outcomes reported
 Veit et al. (2016) found that straw based enrichment can reduce tail biting, similarly, Larson et al. (2018) found straw based enrichment could reduce tail biting, however, other factors contribute more so to reducing tail biting. Haigh et al. (2019) did not find evidence to suggest straw-based enrichment could reduce tail biting. Triggers for tail biting injuries are multifaceted, therefore enrichment alone will not eliminate pen mate manipulation
 Conclusion
 In view of the strength of evidence and the outcomes from the studies the following conclusions have been made; it is expected that these findings provide enough evidence to encourage farmers to introduce novel straw based enrichment as a treatment measure, however it would be most effective if other husbandry factors could be considered in addition
 
 How to apply this evidence in practice
 The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
 Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
 

When treating medial patellar luxation in dogs is a block trochleoplasty superior over a wedge trochleoplasty?

PICO question
 As part of the surgical correction for medial patellar luxation in dogs, which procedure results in a better outcome for the patient: block or wedge recession trochleoplasty?
 
 Clinical bottom line
 Category of research question
 Treatment
 The number and type of study designs reviewed
 Three studies satisfied the inclusion criteria for answering the PICO; one cadaver study, one retrospective observational study and one clinical case series
 Strength of evidence
 Weak
 Outcomes reported
 Postoperative complications including reluxation rates.
 Ex vivo: Trochlear groove depth, patella articular contact, percentage of recessed trochlear surface area, resistance to medial patella luxation
 Conclusion
 There is only weak evidence to support block recession trochleoplasty over wedge recession trochleoplasty as part of the surgical correction for medial patella luxation in dogs. Both procedures are associated with a good clinical outcome. There are some proposed benefits to trochlear block recession made from an ex vivo study comparing the two procedures. These include an increased patellar volume under the trochlear ridges when the stifle is extended. The articular contact and recessed trochlear surface area were also increased in the trochlear block recession group when compared to trochlear wedge recession. However, the clinical relevance of these perceived benefits remains unproven. In practice, and until prospective randomised controlled trials are carried out, veterinary surgeon preference and previous experience remain relevant factors in choosing which procedure to perform
 
 How to apply this evidence in practice
 The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
 Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
 

The relationship between physical self-concept and job satisfaction in the physiotherapists working in Saudi Arabia

Work satisfaction can be seen as a proxy for emotional or physiological health. Physiotherapists face high levels of occupational stress because their daily works puts considerable strain on the articular, skeletal and muscular systems, which are associated with excessive exertion that physiotherapists endure in their daily work. The purpose of present research was to find the relationship of Physical Self-Concept with the job satisfaction of the Physiotherapist working in Saudi Arabia. Study design was Convenient, descriptive-correlation type of study Design. In order to collect the data, the questionnaire on the physical self-concept and the job satisfaction survey were applied. Demographic data of subjects including gender, age, last educational degree, total working experience, the region in which they work, and duration of working on current job, were descriptively summarized to project the results. The dependents variables for the statistical analysis were analyzed using correlation. 189 physiotherapists were surveyed about their Level of PSPP score (M= 63.6, SD= 16.4) and their MSQ score (M= 69.2, SD= 14.7). The relationship was positive, weak in strength and statistically significant (r (189) = .34, p < 0.05. The current study described the relationship between physiotherapists' physical self-concept and job satisfaction.

A Matter of Perspective? The Impact of Analysis Configurations on Testing the Agenda-Setting Hypothesis

The media’s capacity to stimulate public concern and create a common ground for issues can counteract the fragmentation of society. Assessing the intactness of the media’s agenda-setting function can be an important diagnostic tool for scholars. However, the manifold design choices in agenda-setting research raise the question of how design choice impacts analysis results and potentially leads to methodological artefacts. I compare how the choice between 20 plausible analysis configurations impacts tests of the agenda-setting hypothesis, coefficients, and explanatory power. I also explore changes in agenda-setting effect size over time. I develop a typology of analysis configurations from five basic study design types by four ways of linking content analysis to survey data (5 × 4 = 20). The following design types are compared: three single-survey/between designs (aggregate-cross-sectional, aggregate-longitudinal, and individual-level) and two panel-survey/within designs (aggregate-change and individual-change). I draw on the German Longitudinal Election Study data (2009, 2013, and 2017). All 20 tests of the agenda-setting hypothesis support the hypothesis, independent of the analytical configuration used. The choice of analysis configuration substantially impacts the coefficients and explanatory power attributed to media salience. The individual-level analyses indicate that agenda-setting effects became significantly weaker at later elections, though not linearly. This study provides strong empirical support for the agenda-setting hypothesis independent of design choice.

A comparison of supraglottic airway devices versus endotracheal intubation for use in rabbit anaesthesia

PICO question
 In domestic rabbits undergoing anaesthesia, how does the use of supraglottic airway devices compare to endotracheal intubation for ease of use in achieving a patent airway and maintaining a stable anaesthesia?
 
 Clinical bottom line
 Category of research question
 Treatment
 The number and type of study designs reviewed
 Five papers were reviewed to answer this clinical question including four randomised controlled trials, one of which was a randomised crossover trial and one peer-reviewed conference proceeding
 Strength of evidence
 Moderate
 Outcomes reported
 There is evidence to support that supraglottic devices were easier and faster to insert than endotracheal tubes and were used effectively to achieve and maintain a patent airway and anaesthesia. They were however, more easily displaced and took up more space in the oral cavity. Evidence also supports endotracheal intubation can be used to effectively achieve a patent airway and maintain a stable anaesthesia however, can result in more damage to tracheal mucosa when attempted blindly and required higher doses of induction drugs to use
 Conclusion
 Based on current available evidence, endotracheal intubation is an excellent option for maintaining a patent airway and anaesthesia in rabbit patients as it is a tried and tested method, however, can cause tracheal damage if conducted blindly. Supraglottic airways devices can be used as an alternative where endotracheal intubation is unsuccessful. They can also be used where speed of obtaining a patent airway is imperative such as in an emergency as they may be easier and faster to apply, especially in inexperienced practitioners without the necessary equipment for safe endotracheal intubation. Supraglottic devices are unsuitable for procedures that require access to the oral cavity and / or patient movement, due to the size and easier loss of seal during movement potentiating risk of aspiration. Both supraglottic devices and endotracheal intubation are superior to face masks which evidence shows have more leakage, dead space and increased risk of hypercapnia
 
 How to apply this evidence in practice
 The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
 Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
 

Poster 121: Inter- and Intra-Observer Agreement are Unsatisfactory when Determining Study Design and Level of Evidence

Objectives:Understanding differences between types of study design (SD) and level of evidence (LOE) are important when selecting research for presentation or publication and determining its potential clinical impact. The purpose of this study was to evaluate inter- and intra-observer reliability when assigning LOE and SD as well as quantify the impact of a commonly used reference aid on these assessments.Methods:Thirty-six accepted abstracts from the Pediatric Orthopaedic Society of North America (POSNA) 2021 annual meeting were selected for this study. Thirteen reviewers from the POSNA Evidence Based Practice Committee were asked to determine LOE and SD for each abstract, first without any assistance or resources. Four weeks later, abstracts were reviewed again with the guidance of the Journal of Bone and Joint Surgery (JBJS) LOE chart, which is adapted from the Oxford Centre for Evidence-Based Medicine. Inter- and intra-observer reliability were calculated using Fleiss’ kappa statistic (k). Chi-square analysis was used to compare the rate of SD-LOE mismatch between the first and second round of reviews.Results:Inter-observer reliability for LOE improved slightly from fair (k=0.28) to moderate (k=0.43) with use of the JBJS chart. There was better agreement with increasing LOE, with the most frequent disagreement between levels 3 and 4. Inter-observer reliability for SD was fair for both rounds 1 (k=0.29) and 2 (k=0.37). Similar to LOE, there was better agreement with stronger study design. The most common disagreements were between retrospective cohort, retrospective case-control, and case series. Intra-observer reliability was widely variable for both LOE and SD (k=0.10 to 0.92 for both). When matching a selected SD to its associated LOE, the overall rate of correct concordance was 82% in round 1 and 92% in round 2 (p<0.001). Six of the 13 respondents improved in round 2, and 3 were 100% correct both times.Conclusions:Inter-observer reliability for LOE and SD was fair to moderate at best, even among experienced reviewers. Use of the JBJS/Oxford chart mildly improved agreement on LOE and resulted in less SD-LOE mismatch, but did not affect agreement on SD. Professional societies and journals may consider requiring more specific information on SD from authors, while authors and reviewers may benefit from improved instruments to guide SD and LOE designation.

Synthesizing the affinity between employees' internal‐external CSR perceptions and work outcomes: A meta‐analytic investigation

AbstractThis paper contains a meta‐analytic review of 140 research articles and 320 effect sizes to explore how employees' perceptions of internal and external corporate social responsibility (CSR) activities influence an array of work outcomes at three levels (emotional, attitudinal, and behavioral). We aim to discover the underlying psychological and methodological factors affecting this linkage. This study reveals that CSR is more strongly connected with employees' psychological‐emotional reactions (i.e., organizational trust and pride) and work attitude (i.e., organizational commitment) rather than work behavior (i.e., organizational citizenship behavior). Although each type of CSR's association with four work outcomes is positive and significant, wide variance exists in effect sizes reported across studies, warranting a search for substantive moderators. Meta‐regression and subgroup analyses indicate the moderating effects of specific study‐level attributes viz. CSR typology, type of organizational commitment, source &amp; type of organizational citizenship behavior, study design, and other contextual factors. It is found that the CSR‐to‐employee outcome relationship significantly contrasts across industries, regions, and cultures. This paper enriches the extant micro‐CSR literature by emphasizing that CSR can cultivate positive employee sentiments, work attitudes, and behaviors, provided CSR is embedded and integrated innately with sustainable human resource management and core business processes while rising above legal requirements and egocentric motives. Important implications for theorists and managers and potential avenues for future research are conferred in this paper.

Does treatment with clomipramine reduce cat psychogenic alopecia?

PICO question&#x0D; In cats with psychogenic alopecia, is overgrooming reduced by the use of clomipramine compared to untreated cats?&#x0D; &#x0D; Clinical bottom line&#x0D; Category of research question&#x0D; Treatment&#x0D; The number and type of study designs reviewed&#x0D; One pseudo-randomised controlled study&#x0D; Strength of evidence&#x0D; Weak&#x0D; Outcomes reported&#x0D; Effect of clomipramine using owner report of number, intensity, and / or duration of grooming episodes, owner reported clinical improvement, and veterinary measured alopecia, extent of tissue damage, and hair regrowth&#x0D; Conclusion&#x0D; The only controlled study found no evidence that clomipramine alone is effective in reducing grooming episodes, alopecia, or improved hair regrowth. Further research with randomised, double blind controlled trials and limitation of confounding factors is required to determine the efficacy of clomipramine alone or in addition to behavioural / environmental therapies&#x0D; &#x0D; How to apply this evidence in practice&#x0D; The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.&#x0D; Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.&#x0D; &#x0D;

The Bone Lid Technique in Oral and Maxillofacial Surgery: A Scoping Review.

This scoping review aimed at reporting the outcomes of the bone lid technique in oral surgery in terms of bone healing, ridge preservation, and incidence of complications. Bone-cutting instruments and stabilization methods were also considered. PubMed, Scopus, and the Cochrane Register of Controlled Trials were searched using a combination of terms, including bone lid, bony window, piezosurgery, microsaw, cysts, endodontic surgery, impacted teeth, and maxillary sinus. A hand search was also performed. The last search was conducted on 30 November 2021. No date limitation was set. Searches were restricted to human clinical studies published in English. All types of study design were considered except reviews and case reports. After a two-step evaluation, 20 (2 randomized studies, 2 case-control studies, 3 cohort studies, 13 case series) out of 647 screened studies were included, reporting on 752 bone lid procedures. The bone lid technique was associated with favorable bone healing when compared to other methods, and with a very low incidence of major complications. Clinical indications, surgical procedures, study design, follow-up duration, and outcomes varied among the studies. Overall, favorable outcomes were reported using the bone lid approach, though evidence-based studies were scarce.

The role of participatory scenarios in ecological restoration: a systematic map protocol

BackgroundThe scale of land degradation worldwide has led the UN to declare the Decade of Ecosystem Restoration and movements such as the Bonn Challenge (https://www.bonnchallenge.org/), have placed ecological restoration on the global policy agenda. Achieving such ambitious policy targets and restoration goals will necessitate complex trade-offs against limited time, competing knowledge, costs, resources, and varying societal preferences among different stakeholders.Participatory scenarios are a tool to navigate uncertainties surrounding future trajectories and simultaneously incorporate different stakeholder perspectives. They can provide a path to identify collaborative solutions best suited for the local cultures and societies they are tied to. However, there is no systematic understanding of how participatory scenarios are being used in ecological restoration planning to navigate trade-offs in restoration outcomes. We will fill this research gap by mapping the existing evidence from participatory restoration scenarios to answer the primary research question ‘How are outcomes explored in participatory ecological restoration scenarios?’. This will be done through five sub-questions focussing on characteristics of the evidence base, types of study design, how outcomes and trade-offs in those are explored, and an examination of the role of participants in the scenario process and outcome determination.MethodsThis protocol outlines the methods for a systematic map to identify studies that have used participatory scenarios in restoration planning. A comprehensive and reproducible search strategy will be undertaken across bibliographic databases, web-based engines, and targeted searches in organisational online libraries. Searches will be done online in English, but results in all languages will be screened. Search results will go through a two-step screening process of against pre-determined criteria of inclusion and exclusion, for title and abstract and then full-text. Data will be extracted from eligible studies using a standardised data extraction spreadsheet where details on study characteristics, design and outcomes will be recorded. A searchable database of studies and mapping outcomes will be available upon completion of the work. The aim is to inform how scenarios can be better used as a decision-making tool to increase stakeholder participation and account for trade-offs in restoration outcomes across social, ecological, and economic dimensions.

APACHE scoring system and pressure injury risk for intensive care patients: A systematic review and meta-analysis.

The present study was designed to determine the association between Acute Physiology and Chronic Health Evaluation (APACHE) scale and elevated pressure injure (PI) risk in intensive care units (ICU) and also evaluate the predictive value of APACHE score in PI patients. Comprehensive strategies were used to search studies from PubMed, Web of Science, and Ovid Embase electronic databases for observational studies that provided data about APACHE scores related to PI in ICU. Eligible studies were selected based on inclusion and exclusion criteria. The pooled SMD with 95% confidence intervals were calculated. A summary ROC curve was plotted to calculate area under curve (AUC) for APACHE-II (15-20). Twenty-one studies involving 11,102 patients who met selection criteria were included. The 11.0% of patients (1229/11102) in ICU developed PIs. Overall, the PI group had a higher score compared with the non-PI group in the APACHE II (22.1 ± 8.0 vs. 14.5 ± 7.4, mean ± SD). The APACHE-III of PI patients was significantly more than that in the non-PI group (79.9 ± 25.6 vs. 59.9 ± 30.4, mean ± SD). The pooled SMD was 0.82 (95% CI: 0.58-1.06, I2 =91.7%, p-value < 0.001). The subgroup analysis revealed that the risk of PIs did not vary with the type of APACHE score (II, III, IV) and the type of study design (case-control, cross-sectional, cohort, longitudinal study). Proportion of males (I2 = 91.68%, p value=0.090), publish year (I2 = 91.96%, p value=0.187) and mean age of patients (I2 = 91.96%, p value=0.937) were not the sources of heterogeneity. APACHE-II (15-20) achieves the best predictive performance in PI, and the prediction accuracy was balanced with equal sensitivity and specificity (Sen: 0.72, 0.62-0.80; Spec: 1.72, 1.25-2.38). In conclusion, higher APACHE scores are frequently accompanied by a higher incidence of PI among critical-care patients. APACHE-II scores (15-20) satisfactorily predicted PI, and strategies to prevent PI should be aggressively implemented.

The Relationship of Long Work When Using Laptop With Carpal Tunnel Syndrome (CTS) in College Students

&#x0D; Carpal tunnel syndrome is one musculoskeletal disorder that often occurs in work that uses the wrist repeatedly in a position that is not ergonomic for a long time. Use of laptops by students sometimes does not pay attention to ergonomics when typing by using a laptop properly and correctly, so it becomes one of the risk factors for CTS. This study aimed to determine the prevalence of a long-standing relationship between p CTS events, repetitive movements, and wrist posture with CTS incidence in students of the Class of 2017 IKM UNDANA Study Program. This research is a type of quantitative research cross-sectional study design. This study showed no relationship between long-standing with using the laptop, repetitive movements, and wrist posture with complaints of carpal tunnel syndrome in students of the class of 2017 IKM UNDANA study program. This research shows that there needs to be good time management when typing using a laptop, especially for students.&#x0D;

In dogs with atopic skin disease, is lokivetmab more effective than oclacitinib in reducing the score of a recognised scoring system?

PICO question&#x0D; In dogs with atopic skin disease, is lokivetmab more effective than oclacitinib in reducing the Canine Atopic Dermatitis Lesion Index score (or some other recognised scoring system)?&#x0D; &#x0D; Clinical bottom line&#x0D; Category of research question&#x0D; Treatment&#x0D; The number and type of study designs reviewed&#x0D; One randomised controlled trial and one before and after study were critically appraised&#x0D; Strength of evidence&#x0D; Weak&#x0D; Outcomes reported&#x0D; One randomised controlled trial studied the effects of lokivetmab and oclacitinib and found that both drugs were similar in reducing the Canine Atopic Dermatitis Lesion Index (CADESI-03) score.&#x0D; An additional study was evaluated but had non-standardised data as it was a before-and-after study on use of lokivetmab. The paper noted that dogs’ response to oclacitinib can be used to predict how well these dogs respond to lokivetmab. This study also reported a reduction in Pruritus Visual Analog Scale (PVAS) score between before and after lokivetmab administration&#x0D; Conclusion&#x0D; In view of the strength of evidence and outcomes from the studies, there is insufficient quality of evidence to answer the PICO question and so further comparative study is required&#x0D; &#x0D; How to apply this evidence in practice&#x0D; The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.&#x0D; Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.&#x0D; &#x0D;

Effects of Indoor Plants on Human Functions: A Systematic Review with Meta-Analyses.

The influences of indoor plants on people have been examined by only three systematic reviews and no meta-analyses. The objective of this study was therefore to investigate the effects of indoor plants on individuals’ physiological, cognitive, health-related, and behavioral functions by conducting a systematic review with meta-analyses to fill the research gap. The eligibility criteria of this study were (1) any type of participants, (2) any type of indoor plants, (3) comparators without any plants or with other elements, (4) any type of objective human function outcomes, (5) any type of study design, and (6) publications in either English or Chinese. Records were extracted from the Web of Science (1990–), Scopus (1970–), WANFANG DATA (1980–), and Taiwan Periodical Literature (1970–). Therefore, at least two databases were searched in English and in Chinese—two of the most common languages in the world. The last search date of all four databases was on 18 February 2021. We used a quality appraisal system to evaluate the included records. A total of 42 records was included for the systematic review, which concluded that indoor plants affect participants’ functions positively, particularly those of relaxed physiology and enhanced cognition. Separate meta-analyses were then conducted for the effects of the absence or presence of indoor plants on human functions. The meta-analyses comprised only 16 records. The evidence synthesis showed that indoor plants can significantly benefit participants’ diastolic blood pressure (−2.526, 95% CI −4.142, −0.909) and academic achievement (0.534, 95% CI 0.167, 0.901), whereas indoor plants also affected participants’ electroencephalography (EEG) α and β waves, attention, and response time, though not significantly. The major limitations of this study were that we did not include the grey literature and used only two or three records for the meta-analysis of each function. In brief, to achieve the healthy city for people’s health and effective functioning, not only are green spaces needed in cities, but also plants are needed in buildings.

Abstract 732: Weight gain after age 18 and breast cancer risk: A meta-analysis

Abstract Introduction: Current cancer research recognizes that early life factors are important risk factors for breast cancer. Studies suggest that weight gain after age 18 plays a role in the development of breast cancer; however, the research related to their association is inconsistent. Thus, we performed a meta-analysis to evaluate the associations between weight gain after age 18 and risk of breast cancer and to clarify whether there is heterogeneity stratified by menopausal status. Methods: We performed a comprehensive literature search of all relevant studies published prior to February 19, 2021, according to the established inclusion criteria, utilizing Medline (Ovid), Embase, Scopus, Cochrane Library, and ClinicalTrials.gov. Two reviewers independently reviewed the articles for final inclusion. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of studies. Summary risk estimates (REs) with the corresponding 95% confidence intervals (CIs) were calculated using a random-effect or fixed-effect model, based on heterogeneity significance. Subgroup analyses were performed based on types of study design (case-control vs. cohort), country of study (the USA vs. other countries), and menopausal status (premenopausal vs. postmenopausal). We conducted sensitivity analysis and publication bias detection. We performed all statistical analyses with STATA version 16.1, and all P values were two-tailed, the test level was 0.05. Results: Seventeen out of 4,368 unique studies (12 case-control studies and 5 cohort studies) met the selection criteria. All studies were considered moderate to high quality with NOS scores that ranged from 5 to 8. Overall, weight gain after age 18 was associated with an increased risk of breast cancer (RE = 1.27; 95%CI = 1.13 - 1.42). In subgroup analyses, menopausal status was a source of heterogeneity. Weight gain after age 18 was associated with an increased risk of breast cancer among postmenopausal women (RE = 1.45; 95% CI = 1.31 - 1.62), but not among premenopausal women (RE = 1.03; 95% CI = 0.95 - 1.11). We did not find differences in associations by type of study design (case-control study: RE = 1.28; 95%CI = 1.09 - 1.51; cohort study: RE = 1.24; 95%CI = 1.07 - 1.44) nor country of study (the USA: RE = 1.28; 95%CI = 1.13 - 1.45; other countries: RE = 1.25; 95%CI = 0.94 - 1.66). The sensitivity analysis confirmed the stability of the results. The funnel plot suggested no publication bias. Conclusion: The current meta-analysis demonstrates that weight gain after age 18 is associated with increased breast cancer risk in postmenopausal women but not in premenopausal women. These findings suggest that it is important to keep weight within the healthy range and manage weight gain in adult life to fight against breast cancer among postmenopausal women. Citation Format: Yunan Han, Ebunoluwa E. Otegbeye, Carrie Stoll, Angela Hardi, Graham A. Colditz, Adetunji T. Toriola. Weight gain after age 18 and breast cancer risk: A meta-analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 732.

Comparing delayed versus on-arrival administration of a modified live viral vaccine in feedlot cattle

PICO question&#x0D; In auction market calves at high risk of developing bovine respiratory disease (BRD), does delayed (14–30 days) vaccination with a modified live vaccine (MLV) for viral respiratory pathogens versus administration of MLV on-arrival (within 24 hours of arrival) to the feedlot, result in a decreased percentage of calves with BRD morbidity diagnosed based on visual signs and rectal temperature &gt;40 degrees Celsius?&#x0D; &#x0D; Clinical bottom line&#x0D; Category of research question&#x0D; Treatment&#x0D; The number and type of study designs reviewed&#x0D; Two papers were critically reviewed. Both are randomised complete block designs&#x0D; Strength of evidence&#x0D; Weak&#x0D; Outcomes reported&#x0D; Delaying administration of a modified live respiratory vaccine to feedlot cattle may result in lower BRD retreatments&#x0D; Conclusion&#x0D; In feedlot calves, delaying modified live vaccine administration for viral respiratory pathogens may result in lower BRD retreatment rates than cattle receiving the vaccine on arrival to the feedlot. Significant statistical data from one study supported this conclusion while another showed numerically less retreatments in calves vaccinated on arrival versus delayed vaccination&#x0D; &#x0D; How to apply this evidence in practice&#x0D; The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.&#x0D; Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.&#x0D; &#x0D;