Types Of Sleep Disorders Research Articles

Associations between dietary nutrient intake and sleep disorders in cancer survivors base on NHANES 2005 to 2018.

Sleep disorders significantly impact the quality of life for many individuals, which remain largely unrecognized. It is widely believed that dietary nutrient intake plays a crucial role in promoting healthy sleep patterns. However, there is lack of research focusing on cancer survivors. This study utilized the National Health and Nutrition Examination Survey (NHANES) database to investigate the correlation between dietary nutrient intake and sleep disorders in cancer survivors. Analyzing data from 2882 cancer survivors in NHANES spanning from 2005 to 2018. Dietary nutrient intake was evaluated through two 24-h dietary recalls. Weighted multivariable logistic regression model was employed to further applied to explore the association between dietary fiber intake and sleep disorders while controlling for relevant confounding factors. Additionally, the nonlinear and dose-response relationships were explored using restricted cubic spline (RCS) regression along with smooth curve fitting and threshold effect analysis. Stratified analysis and interaction analysis were conducted to assess the consistency of the results. Univariable and multivariable analysis demonstrated that dietary fiber intake showed negative correlation with sleep disorders (P < 0.05). Treating dietary fiber intake as continuous variable. After accounting for all covariates, the study reaffirmed the protective role of dietary fiber (odds ratio [OR]: 0.99, 95% confidence interval [CI]: 0.98-0.99, P = 0.044). Analysis of dietary fiber intake in quartiles further supported this trend (P < 0.001). Interestingly, further investigations indicated that dietary fiber intake was not associated with sleep apnea, insomnia, restless legs syndrome, or other types of sleep disorders (P > 0.05). Notably, no statistically significant interactions were observed in all subgroup analyses except poverty income ratio (PIR) (P for interaction < 0.05), indicating that the protective effect of dietary fiber on sleep disorders was more pronounced in individuals with PIR ≥2.5. Our results suggest that adequate dietary fiber intake may be beneficial dietary strategy to reduce sleep disorders in cancer survivors.

The Association Between Dietary Vitamin C and Sleep Disorders: A Cohort Study Based on UK Biobank

Objective: Approximately 30% of adults globally suffer from sleep disorders. However, there are few longitudinal studies on the association between dietary vitamin C and sleep disorders. This study aimed to investigate the association between dietary vitamin C intake and various types of sleep disorders, including sleep apnea and insomnia. Methods: We enrolled 68,221 participants from the UK Biobank. Dietary vitamin C intake was assessed using a 24 h dietary recall questionnaire. We employed a Cox regression model to assess the association between dietary vitamin C and sleep disorders and used restricted cubic spline models to investigate potential nonlinear relationships. Stratified and sensitivity analyses were also conducted to validate the findings. Results: The results indicated that vitamin C intake at the Q4 level (132.88–191.51 mg/d) was significantly associated with a reduced risk of sleep disorders, with an HR (95% CI) of 0.78 (0.65–0.94), and against sleep apnea, with an HR (95% CI) of 0.75 (0.62–0.92). The protective effect persisted significant in stratified analyses of men and those aged ≤ 60 years; the results were consistent in the sensitivity analyses. Conclusions: Our findings suggest that sufficient dietary vitamin C intake may help to prevent sleep disorders.

Retinal Diabetopathy? Sleep Disorders, Retinal Changes, and Insulin Resistance: A Synthesized Systematic Review

ABSTRACT Sleep disturbances, particularly prevalent in modern lifestyles, have been increasingly associated with metabolic disorders such as insulin resistance and type 2 diabetes mellitus (DM) (T2DM). Epidemiological evidence underscores the link between impaired sleep and elevated risks of cardiovascular diseases and mortality rates, alongside the emergence of metabolic dysregulation. Notably, conditions such as obstructive sleep apnea syndrome contribute to disrupted sleep architecture and exacerbate insulin resistance through repeated drops in blood oxygen levels during sleep. Furthermore, chronic sleep deprivation, irregular sleep schedules, and shift work disrupt circadian rhythms, amplifying the risk of metabolic disorders. A comprehensive search was conducted in PubMed, Scopus, Web of Science, and Google Scholar for articles from January 2010 to October 2023 using terms such as “sleep disturbances,” “Type 2 Diabetes Mellitus,” and “retinal receptors.” Inclusion criteria covered studies on human and animal participants, comparative analyses, and reviews. Exclusion criteria ruled out nonpeer-reviewed works and those with limited population sizes. Data extraction focused on study design, populations, types of sleep disorders, metabolic effects, and retinal health impacts. Results emphasized the bidirectional relationship among these variables. The critical analytical research and review highlights the bidirectional relationship between retinal receptor dysfunction and DM, emphasizing how metabolic disturbances associated with diabetes impact retinal health, while dysfunctional retinal receptors contribute to the progression of diabetes-related complications. Insights into the role of insulin receptors in the retina and the blood–retinal barrier underscore the mechanisms through which insulin resistance compromises retinal integrity, leading to neuroinflammation, oxidative stress, and photoreceptor damage. The disturbed sleep can also affect the melatonin secretion, thereby affecting insulin resistance. We preliminarily have named the nexus as retinal diabetopathy. By elucidating the impact of intermittent hypoxia and sleep fragmentation on cellular signaling and metabolism, particularly in vital organs such as muscles, liver, fat, and pancreas, the article provides a comprehensive understanding of how prevalent sleep disturbances and retinal changes contribute to the development and progression of T2DM. Overall, this research underscores the importance of addressing sleep disorders in the prevention and management of metabolic disorders.

Clinically recognized sleep disorders in people living with HIV.

Despite recognition that people with HIV (PWH) are more vulnerable to sleep issues, there is limited understanding of clinically recognized sleep disorders in this population. Our objective was to evaluate the full spectrum of sleep disorder types diagnosed among PWH in care. We conducted a retrospective cohort study of PWH, and a comparator group of people without HIV (PWoH), in a large healthcare system. The incidence of clinically diagnosed sleep disorders was calculated using Poisson regression for three outcomes: any type of sleep disorder, insomnia, and sleep apnea. Incidence was compared between PWH and PWoH by computing the adjusted incidence rate ratio (aIRR), accounting for sleep disorder risk factors. Comparisons to PWoH were made for all PWH combined, then with PWH stratified by HIV management status (well-managed HIV defined as being on antiretroviral therapy, HIV RNA <200 copies/mL, and CD4 count ≥500 cells/μL). The study included 9076 PWH and 205 178 PWoH (mean age 46 years, 90% men). Compared with PWoH, sleep disorder incidence was greater among PWH overall [aIRR = 1.19, 95% confidence interval (CI): 1.12-1.26], particularly for insomnia (aIRR = 1.56, 95% CI: 1.45-1.67). Sleep apnea incidence was lower among PWH (aIRR = 0.90, 95% CI: 0.84-0.97). In HIV management subgroups, PWH without well-managed HIV had lower sleep apnea incidence (vs. PWoH: aIRR = 0.79, 95% CI: 0.70-0.89) but PWH with well-managed HIV did not (vs. PWoH: aIRR = 0.97, 95% CI: 0.89-1.06). PWH have high sleep disorder incidence, and insomnia is the most common clinical diagnosis. Lower sleep apnea incidence among PWH may reflect underdiagnosis in those with sub-optimally treated HIV and will be important to investigate further.

Sleep Disorder Detection Using EEG Signals

Sleep disorders are prevalent health concerns affecting millions of individuals worldwide, with adverse impacts on overall well-being and cognitive function. Detecting and diagnosing these disorders accurately is crucial for effective treatment planning and management. This project focuses on utilizing Electroencephalogram (EEG) signals, a non-invasive method for monitoring brain activity, to detect sleeping disorders. By leveraging advanced signal processing techniques and machine learning algorithms, this research aims to develop a robust and accurate system capable of identifying various types of sleep disorders, such as insomnia, sleep apnea, and narcolepsy, based on EEG data. The proposed approach holds the potential to enhance early detection, personalized treatment strategies, and ultimately improve the quality of life for individuals affected by sleep disorders. Keywords-Ambulatory EEG, automatic scoring, deep learning, electroencephalography, sleep staging.

Higher ambient temperatures may worsen obstructive sleep apnea: A nationwide smartwatch-based analysis of 6.2 million person-days

Obstructive sleep apnea (OSA) is a serious type of sleep disorder that can lead to cardiometabolic and neurocognitive diseases. We utilized smart device-based photoplethysmography technology to collect sleep data from the Chinese population from 2019 to 2022. Distributed lag nonlinear models combined with a generalized nonlinear model or a linear mixed effects model were used to investigate the short-term associations between daily temperature and indicators of OSA severity. We included a total of 6,232,056 d of sleep monitoring data from 51,842 participants with moderate to severe risk of OSA from 313 Chinese cities. The relationships between ambient temperature and OSA exacerbation, apnea-hypopnea index (AHI), and minimum oxygen saturation (MinSpO2) were almost linear and present only on the same day. Higher temperatures were associated with a greater risk of OSA exacerbation, with an 8.4% (95% confidence interval (CI): 7.6%–9.3%) increase per 10 °C increase in temperature. A 10 °C increase in daily temperature corresponded to an AHI increase of 0.70 events/h (95% CI: 0.65–0.76) and a MinSpO2 decrease of 0.18% (95% CI: 0.16%–0.19%). Exposure to elevated temperatures during the night can also lead to adverse effects. The effects of higher temperatures on OSA severity were stronger among men, participants with a body mass index ≥ 24 kg/m2, those aged 45 years and older, individuals with a history of hypertension and diabetes, and during the cold season. This large-scale, nationwide, longitudinal study provides robust evidence suggesting that higher ambient temperatures may immediately worsen OSA.

Role of exercise in reducing the risk of cardiovascular diseases associated with sleep disorders.

Cardiovascular diseases are the leading cause of death among urban and rural residents and have become a major global public health problem. The prevention and control of cardiovascular disease risk factors is crucial for preventing, stabilizing, and even reversing cardiovascular disease. Studies have found that certain sleep disorders are directly related to cardiovascular disease and may be induced through pathways such as endothelial dysfunction, dysregulation of autonomic homeostasis, inflammatory response, and metabolic dysfunction. Exercise helps improve sleep disorders and thus reduce the risk of cardiovascular disease, and has irreplaceable advantages over pharmacological treatments for improving sleep. Different types of sleep disorders should be adjusted by factors such as exercise mode, intensity, and duration of exercise. A good sleep state further reduces the risk of cardiovascular disease. Discussing the effect of exercise on the improvement of the risk of cardiovascular disease associated with sleep disorders, and elaborating the mechanism of action of exercise in reducing the risk of cardiovascular disease from the perspective of sleep, can lay a foundation for the treatment of sleep disorders by exercise and propose new directions for reducing cardiovascular disease risk.

The Chinese Clinical Sleep Database: An Innovative Database System Includes Large-Scale Clinical Data of Chinese Population.

In this study, we established the Chinese Clinical Sleep Database (CCSD), aiming to provide a safe, scalable, and user-friendly database that includes high-quality clinical data from Chinese population to facilitate sleep research. We collect individual's demographic data, scales, anthropometric measurements, clinical diagnosis, and polysomnography (PSG) recordings from the routine medical process of sleep medicine centers using standardized procedures. The distributed cluster storage technology are utilized to store these data. The structured data are stored in a high-performance MySQL database, while the unstructured data are stored in an object storage service. And we have developed an online data platform to share and manage our data. The data collection has been conducted in three hospitals. In the preliminary stage of data collection (from October 18, 2022 to September 4, 2023), our database included a total of 1183 patients. Among them, 56.8% were male and their ages ranged from 3 to 88 years. These patients were diagnosed with various types of sleep disorders. Since the CCSD's inception, it has demonstrated good stability, security, and scalability. As an public database, the CCSD also exhibits user-friendliness. The CCSD contains comprehensive clinical data, which can contribute to the advancement of the diagnosis and treatment strategies for sleep disorders, ultimately promoting sleep health.

Current Pharmacological Treatment for Sleep Disorders in Children and Adolescents with Autism Spectrum Disorder

Sleep disorders are very common in children and adolescents with Autism Spectrum Disorder (ASD) and can negatively impact their lives, mental health, developmental processes, families' lives, and emotional well-being. It is essential to determine the specific sleep disorder and its underlying cause in treatment planning. Currently, nonpharmacological and pharmacological interventions are the main treatments for improving sleep disorders in children and adolescents with ASD. If nonpharmacological strategies are unsuccessful or difficult to implement, medications should be considered and used in conjunction with them. Melatonin, behavioral interventions, and parent education are the most effective treatments to improve sleep, relative to other pharmacological treatments. Medications used to treat sleep disorders in these children are used off-label. Melatonin appearing to be safe and effective may be an evidence-based and efficacious first-line treatment for treating insomnia symptoms in children and adolescents with ASD. Antipsychotics (e.g.low dose quetiapine), antidepressants with strong sedative effects such as trazodone and mirtazapine, antihistamines (e.g.diphenhydramine, niaprazine), alpha-adrenergic drugs (e.g. clonidine), benzodiazepines (e.g.clonazepam) and other hypnotic drugs, anticonvulsants (e.g. gabapentin), Alzheimer's drugs (e..g donepezil), superoxide and iron treatment are other drugs used in pharmacological treatment. Depending on the type of sleep disorders and the presence of comorbidities, the most effective pharmacological treatment should be selected on a case-by-case basis.

Sleep disorders, anxiety and obesity associated with untreated dental caries in children eight to ten years of age.

To evaluate the presence of sleep disorders, obesity and anxiety associated with cavitated carious lesions in children aged 8 to 10 years. A cross-sectional study was carried out in the Northeast of Brazil. The sample was comprised of 793 schoolchildren randomly selected from public and private schools. Calibrated examiners (Kappa >0.80) performed the clinical examination of dental caries using the International Caries Detection and Assessment System and applied the Revised Children's Manifest Anxiety Scale and the Sleep Disturbance Scale for Children questionnaires. The anthropometric variables evaluated were weight and height. Negative binomial regressions (α ≤ 0.05) were performed. A Directed Acyclic Graph was prepared using DAGitty software (version 3.0), to select the co-variables for the statistical fits. The prevalence of tooth decay was 52.8%. The mean number of tooth surfaces with cavitated caries was 2.2(2.8), 58.9% of the schoolchildren had some type of sleep disorder, while 20.2% were anxious and 29.1% were obese. Sleep disturbance (RR = 1.38; 95% CI: 1.05-1.83), general anxiety (RR = 1.71; 95% CI: 1.32-2.21), obesity (RR = 1.48; 95% CI: 1.17-1.86) were associated with dental caries in the final model. The presence of carious lesions was higher in children with sleep disorders, anxiety, obesity, and those who experienced dry mouth.

Progress in the causes of sleep disorders during the early-stage Alzheimer’s disease

The most prevalent chronic disease among senior people, and its prevalence rises with age, is Alzheimer’s disease (AD). One study predicts that the prevalence of dementia will triple globally by 2050. Sleep disorder (sleep disturbance) is a condition that also often occurs in the elderly population. More than about 25%~60% of AD patients have sleep disturbances or circadian rhythm changes. But the sleep disorders during the early stage of AD have not been uniformly recognized. Of the stages of AD, those experiencing the early stage have the most patients. Therefore, this paper summarises the conditions and types of sleep disorders in the first stage of AD, and the articles of sleep disorders of that time lesions are retrieved and analysed. This paper also deals with two pathological mechanisms during early AD: beta amyloid (Aβ) accumulation and tau protein entanglement. By describing the effects of two western drugs and a Chinese herbal medicine, this paper shows that sleep disorders in older adults may suggest mild cognitive impairment and that more attention needs to be paid to what current research suggests. Early AD lesions can lead to sleep disorders and the search for more accurate biomarkers will be a major driver in the development of diagnostics that may delay AD onset.

A study of sleep problems and its associated factors among patients presenting in psychiatry OPD at tertiary-level hospital in Nepal

Background: Sleep disturbances amongst those with psychiatric disorders are quite common and may occur as a primary disorder or in association with any psychiatric disorders. The aim of this study is to find out the prevalence of sleep disorders and its associated factors in psychiatric outpatients. Material &amp; Methods: This cross- sectional study was conducted among the patients presenting in the psychiatric opd, from 1st Feb 2022 to 30th July, 2022 in tertiary level hospital in Nepal. Total 217 samples were included and purposive sampling technique was applied for sample collection. After written informed consent from participants socio-demographic data were collected. Athens Insomnia scale (ASI) and Screening symptoms of sleep disorder(s) were the tools applied to the participants to find out types of sleep disorders. Results: In our study, sleep disorders were found in 66.8% of the patients presenting to psychiatric opd. Insomnia was the most common finding accounting for 59.4 % of the participants. Narcolepsy was found in 2.3% whereas parasomnia was found in 5.1 %; periodic limb movement disorder/Restless leg syndrome (PLMD/RLS) in 5.1%; disturbed circadian rhythm was found in 3.7% and Sleep Related Breathing Disorder was found in 5.1% of the participants. Patients diagnosed with mood disorder (80.4%) and primary headache disorders (82.9%) had more sleep problems compared to other diagnosis. Conclusion: This study was the first in Nepal to assess the prevalence of sleep disorders in psychiatric outpatients. Our study emphasis importance of careful evaluation of sleep problems for proper management of the psychiatric patients.

Thyroid disease-related sleep disorders and its diagnostic and therapeutic recommendations: A literature review

As perioperative medicine evolves, more hospitals are offering comfort sleep clinics. Thyroid disorders (e.g., hypothyroidism, hyperthyroidism, and thyroid cancer) affect the peripheral circadian clock. Elevated serum thyroid-stimulating hormone levels have been found to associate with the incidence of thyroid cancer in humans, but the relationship between circadian disruption and thyroid disease requires further investigation. Malignant transformation of thyroid nodules is characterized by disruption of the expression of biological clock genes. Sleep clinics often see patients complaining of sleepiness and tinnitus. These patients often have comorbid thyroid disorders and are therefore highly susceptible to misdiagnosis or underdiagnosis. In this article, we first summarize this category of disorders, which we propose to classify as insomnia secondary to somatic disease and define as thyroid disease-related sleep disorder (TSD). The primary and common clinical complaints of TSD patients are different types of sleep disorders. In addition, we attempt to provide some preliminary diagnostic and therapeutic recommendations for TSD in the hope that it may assist healthcare professionals in the early diagnosis and management of this disorder.

Sleep problems in children with autism spectrum disorder and attention-deficit/hyperactivity disorder: A comparative study and effects on communication skills.

Sleep disturbances are highly prevalent among children with neurodevelopmental disorders, like Autism Spectrum Disorder (ASD) and Attention-Deficit/Hiperactivity Disorder (ADHD). The first objective of this study is to examine the differences in sleep problems between a group of children with ASD without intellectual disabilities, a group with ADHD and a typically developing (TD) group. A second objective is aimed at analyzing the effects of sleep problems and symptom severity on their communication skills. Participants were 122 children between 7 and 12 years old distributed in three groups: 32 TD children, 47 children with ASD and 43 children with ADHD, matched on age and intelligence. Parents completed different questionnaires that measured sleep disturbances and communication skills. Findings show significant differences between the clinical groups and the TD group in most types of sleep disorders. Moreover, the group with ADHD showed significantly more sleep breathing disorders and hyperhidrosis in comparison with ASD and TD, as well as more total sleep problems. In contrast to ASD, the predictive power of sleep problems on communication difficulties was greater in the group with ADHD. The results of the mediation analysis indicate that in both groups, sleep problems partially mediate the relationship between symptoms and communication. This investigation highlights the need of considering sleep disorders when assessing communication skills in ASD and ADHD, given its indirect influence in this domain. Understanding the sleep dysfunctions of both conditions and their repercussions is crucial to develop adjusted interventions.

Sleep disorders and changes in melatonin concentrations in pregnant women with preeclampsia

Melatonin plays a significant role in the development of normal pregnancy, in particular, it contributes to the successful implantation of the fertilized egg, affects the act of childbirth, is actively produced by the trophoblast and placenta, reduces oxidative stress, in particular, with preeclampsia. In addition, melatonin is one of the essential hormones in the protection of the endothelium and stem cells from the oxidant stress. Objective – to study the mechanisms of development, terms of manifestation, and types of sleep disorders, as well as changes in the concentrations of melatonin in the blood of pregnant women with preeclampsia. Material and methods. 50 pregnant women at a mean age of 29.1±3.4 years who had preeclampsia in the 3rd pregnancy trimester were examined (experimental group). All women in the research group had a gestation term of 30-32 weeks of pregnancy. The control group consisted of 33 women with a mean age of 31.2±6.6 years who had an uncomplicated pregnancy. The presence of sleep disorders was established using a questionnaire: pregnant women were asked about the term of pregnancy in which complaints of sleep disorders appeared, the nature of sleep disorders, the frequency of episodes of sleep disorders (how many times a week such a condition was noted), etc. The concentration of melatonin in the venous blood of the examined pregnant women was also determined, for which IBL melatonin ELISA diagnostic kits manufactured by IBL, Germany were used. Blood was taken at 9:00 a.m., on an empty stomach, and all patients were analyzed at the same time of a day. Results and their discussion. The study showed that sleep disorders in pregnant women with pre-eclampsia, which complicates the pregnancy in the 3rd trimester, occurred earlier, compared to women with an uncomplicated course of pregnancy: pregnant women with pre-eclampsia were more likely to notice worsening of sleep, starting from 22-30 weeks of pregnancy (in 26.0 % of cases), while in pregnant women with a physiological course of gestation, similar complaints appeared mainly after 30 weeks. In the third trimester of pregnancy women with preeclampsia were more likely to wake up 2 or more times per night (in 68.0 % of cases) compared to controls (in 23.3 % of cases, p &lt; 0.001) and 3 or more times per night per week (in 54.0 % of cases, in controls – in 16.7 % of cases, p &lt; 0.001), which may be a consequence of a disorder of the function of the pineal gland. Women with preeclampsia were more likely (56.0 % vs. 13.3 % in the control group, p &lt; 0.01) to use gadgets (electronic devices, mainly smartphones) for more than 2 hours after 9:00 p.m., which also negatively affects the function of the pineal gland. In pregnant women whose pregnancy was complicated by preeclampsia in the 3rd trimester, a significant (1.78-fold) decrease in the level of melatonin in venous blood taken at 9 a.m. was observed, compared to women with an uncomplicated pregnancy (p = 0.029). Conclusions. Sleep disorders in pregnant women with preeclampsia occur earlier and are more expressed compared to women with an uncomplicated course of pregnancy. The appearance of complaints of insomnia in the second trimester of pregnancy, in our opinion, can be considered a diagnostic sign of pineal gland dysfunction in preeclampsia. A decrease in the level of melatonin in pregnant women with preeclampsia, established against the background of minimal daily activity of the pineal gland (at 9 a.m.), indicates a decrease in the melatonin-producing function of the placenta which might have an impact on the condition of stem cells of fetus and placenta.

Sleep Disorders in Early-Onset Parkinsonism: A Population-Based Study.

Sleep disturbances are common in parkinsonian disorders; however, whether sleep disorders affect individuals with early-onset parkinsonism and whether they differ from individuals with typical-onset parkinsonism is unknown. To compare the prevalence and incidence of sleep disorders before and after parkinsonian motor symptom onset between individuals with early onset parkinsonism (age ≤50 at motor symptom onset) and typical-onset parkinsonism (age >50 at motor symptom onset). We used a population-based, 1991 to 2015 incident-cohort study of parkinsonism including 38 patients with early-onset and 1,001 patients with typical-onset parkinsonism. Presence or absence and type of sleep disorder as well as the relationship between motor and sleep symptoms were abstracted from the medical records. Rates of sleep disorders before and after onset of parkinsonism were compared with logistic regression and Cox proportional hazards models. The prevalence of sleep disorders prior to the onset of parkinsonism in early vs. typical parkinsonism (24% vs. 16% p = 0.19) and incidence of sleep disorders after parkinsonism onset (5.85 cases per 100 person-years vs. 4.11 cases per 100 person-years; HR 1.15 95% CI: 0.74-1.77) were similar between the two groups. Early-onset parkinsonism had a higher risk for developing post-motor insomnia compared with typical-onset parkinsonism (HR 1.73, 95% CI: 1.02-2.93); the risk for developing all other sleep disorders considered was similar between groups. Sleep disorders are common in individuals with early-onset parkinsonism and occur with similar frequency to those with typical-onset parkinsonism, except for insomnia, which was more frequent in the early-onset group.

The Role of Genetic Mutations on Genes PER2, DEC2, ADRB1 in Bio-Psychological Sex Insomnia Disorder

Sexsomnia, also known as sleep sex, is a type of sleep disorder known as parasomnia. Parasomnias refer to unusual sensations and behaviors, such as sleepwalking, that people may experience during sleep. In the case of sex, people perform sexual behaviors such as masturbation, sexual movements, sexual assault, or initiating sex with another person. Although their eyes may be open and they may make sexual sounds, they are asleep during these activities and are unaware of their behavior upon awakening. Research on the causes of sexual insomnia is limited, but experts have found that it is associated with a wide range of underlying conditions and risk factors, including: other parasomnias, such as sleepwalking and REM behavior disorder, obstructive sleep apnea, seizures sleep disorders, Kline-Lewin syndrome, chronic insomnia, restless legs syndrome, narcolepsy, persistent sexual arousal syndrome, sleep-related disorders, nocturnal psychotic disorders, teeth grinding.

The Effects of Different Types of Sleep Disorder on Colorectal Cancer: A Nationwide Population-Based Cohort Study.

The impact of sleep disorders (SDs), particularly sleep apnea (SA), on the development of colorectal cancer (CRC) has been the subject of significant research. However, the potential contribution of other SDs to the incidence of CRC remains unexplored. The objective of this study was to examine the effects of SDs on the risk of developing CRC. This study assessed CRC risk among individuals diagnosed with SDs compared with age- and sex-matched unaffected individuals. A longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) encompassing 177,707 individuals diagnosed with SDs and 177,707 matched controls. Cox proportional hazard regression analysis was used to determine the relative increased risk of CRC in individuals with SDs and specific subgroups of SDs. The CRC incidences were 1.32-fold higher (95% CI 1.23-1.42) in the overall SD cohort, 1.17-fold higher (95% CI 0.82-1.68) in the SA cohort, 1.42-fold higher (95% CI 1.31-1.55) in the insomnia cohort, 1.27-fold higher (95% CI 1.17-1.38) in the sleep disturbance cohort, and 1.00-fold higher (95% CI 0.77-1.29) in the other SD cohort, after adjusting for age, sex, and comorbidities.

Effect of PLA2G6 and SMPD1 Variants on the Lipid Metabolism in the Cerebrospinal Fluid of Patients with Parkinson's Disease: A Non-targeted Lipidomics Study.

Sleep patterns are more frequently interrupted in patients with Parkinson's disease (PD), and it is still unclear whether genetic factors are involved in PD-related sleep disorders. In this study, we hypothesize that PD-associated genetic risk affects lipid metabolism, which in turn contributes to different types of sleep disorders. We used a non-targeted lipidomics to explore the lipid composition of cerebrospinal fluid (CSF) exosomes derived from patients with PD carrying phospholipase A2 Group VI (PLA2G6) and sphingomyelin phosphodiesterase 1 (SMPD1) mutations. PLA2G6 mutations (c.1966C>G, Leu656Val; c.2077C>G, Leu693Val; c.1791delC, His597fx69) significantly increase the exosomal content of glycerophospholipids and lysophospholipids, specifically phosphatidylcholine (PC) and lysophosphatidylcholine (LPC). Exosome surface presence of melatomin receptor 1A (MTNR1A) was detectable only in patients with PLA2G6 mutations. We have further shown that, in patients with PD carrying PLA2G6 mutations, sleep latency was significantly longer compared to those carrying WT PLA2G6, and we speculate that functional PLA2G6 mutations lead to structural changes and lipid deregulation of exosomes, which in turn alters exosomal cargo and affects PD-related sleep disorders. In SMPD1, G508R variant-carrying patients with PD abundance of sphingomyelins was significantly higher and had significantly shorter rapid eye movement sleep. Our study demonstrated that the disturbed composition and function of CSF-derived exosome lipidome during the pathological stage of PD may affect different types of sleep disorder in PD.

Association of sleep disorders with asthma: a meta-analysis

BackgroundAnimal experiments and clinical trials have revealed a potential relationship between sleep disorders and asthma. However, the associations between these factors remain unclear.Material and methodsWe searched PubMed, Embase, Web of...