Because of greater concern of nitrogen dioxide (NO2) pollution for urban residents, monitoring efforts are typically focused in urban areas. However, large populations in suburban areas near urban centers may also experience elevated NO2 levels. This study focuses on the application of a land use regression (LUR) model to predict NO2 pollution in the suburban and urban areas around the city of Philadelphia, Pennsylvania, USA. Air pollutant measurements used for the LUR was obtained from Ogawa™ passive samplers, which were deployed at several sites (n = 15) throughout the Greater Philadelphia area. Passive samplers were deployed for two weeks each during the fall, winter, and spring months between 2021 and 2022. Predictor data included various spatial buffers of land use, landcover, and traffic counts, as well as distances to various roadway types. The best LUR model based on regression statistics (F-statistic with 4 and 10 degrees of freedom = 5.111, p < 0.05) showed that mean NO2 concentrations increase within a 1000m buffer of annual average daily traffic. The model shows a patchwork of NO2 concentrations throughout the study area that could indicate regional and local emissions. The results highlight spatial variations of elevated concentrations influenced by a mix of land use, including roads, residential, and industrial areas.