Objectives: Investigate the use and outcomes of adjuvant chemotherapy for patients with FIGO stage II endometrioid carcinoma of the uterus receiving adjuvant radiation therapy following hysterectomy. Methods: Patients without a history of another tumor diagnosed between 2010 and 2015 with pathological stage II endometrioid adenocarcinoma of the uterus with known tumor grade who underwent hysterectomy with at least 10 lymph nodes removed and received adjuvant radiation therapy with or without adjuvant chemotherapy and had at least one month of follow-up were identified in the National Cancer Database. Overall survival (OS) was compared with the log-rank test following generation of Kaplan-Meier curves. A Cox multivariate model was constructed to control for confounders. Results: A total of 1569 patients were identified; 50.1% received vaginal brachytherapy, 19.1% external beam radiation therapy and 30.8% combination of both. Chemoradiation was administered to 257 (16.4%) patients. Chemoradiation use for patients with grade 3 tumors was 38% compared to 10.2% and 9.5% for those with grade 2 and grade 1 tumors respectively, p<0.001. Patients who received chemoradiation were more likely to have lymph-vascular invasion (LVSI) (46.6% vs 28.9%, p<0.001), private insurance (56.4% vs 48.2%, p=0.03) and be treated in academic facilities (48.4% vs 41.8%, p=0.051). The two groups were comparable in terms of patient age, race, presence of comorbidities, type of radiotherapy administered, type of hysterectomy performed and tumor size, p>0.05. There was no difference in OS between patients who received chemoradiation or radiation alone p=0.60; 4-year OS rates were 85.3% and 87.4% respectively. Compared to radiation alone, chemoradiation was not associated with better OS for among patients with grade 3 tumors (p=0.88) or those with LVSI (p=0.57). After controlling for patient age, race, insurance, comorbidities, tumor size and presence of LVSI, chemoradiation was not associated with better survival compared to radiation alone (HR: 0.85, 95% CI 0.56, 1.30). Conclusions: The addition of chemotherapy to adjuvant radiation therapy was not associated with a survival benefit for patients with FIGO stage II endometrioid carcinoma. Investigate the use and outcomes of adjuvant chemotherapy for patients with FIGO stage II endometrioid carcinoma of the uterus receiving adjuvant radiation therapy following hysterectomy. Patients without a history of another tumor diagnosed between 2010 and 2015 with pathological stage II endometrioid adenocarcinoma of the uterus with known tumor grade who underwent hysterectomy with at least 10 lymph nodes removed and received adjuvant radiation therapy with or without adjuvant chemotherapy and had at least one month of follow-up were identified in the National Cancer Database. Overall survival (OS) was compared with the log-rank test following generation of Kaplan-Meier curves. A Cox multivariate model was constructed to control for confounders. A total of 1569 patients were identified; 50.1% received vaginal brachytherapy, 19.1% external beam radiation therapy and 30.8% combination of both. Chemoradiation was administered to 257 (16.4%) patients. Chemoradiation use for patients with grade 3 tumors was 38% compared to 10.2% and 9.5% for those with grade 2 and grade 1 tumors respectively, p<0.001. Patients who received chemoradiation were more likely to have lymph-vascular invasion (LVSI) (46.6% vs 28.9%, p<0.001), private insurance (56.4% vs 48.2%, p=0.03) and be treated in academic facilities (48.4% vs 41.8%, p=0.051). The two groups were comparable in terms of patient age, race, presence of comorbidities, type of radiotherapy administered, type of hysterectomy performed and tumor size, p>0.05. There was no difference in OS between patients who received chemoradiation or radiation alone p=0.60; 4-year OS rates were 85.3% and 87.4% respectively. Compared to radiation alone, chemoradiation was not associated with better OS for among patients with grade 3 tumors (p=0.88) or those with LVSI (p=0.57). After controlling for patient age, race, insurance, comorbidities, tumor size and presence of LVSI, chemoradiation was not associated with better survival compared to radiation alone (HR: 0.85, 95% CI 0.56, 1.30). The addition of chemotherapy to adjuvant radiation therapy was not associated with a survival benefit for patients with FIGO stage II endometrioid carcinoma.
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