Background: High-flux haemodialysis uses dialysis membranes of significant porosity to permit the passage of larger molecules (β2-microglobulin clirens >20 ml/min) and allows a higher coefficient of ultrafiltration (CUF >l5 ml/mmHg per hour). Preliminary results found that anaemia was more easily corrected among patients treated with high-flux membranes, while randomised trials failed to prove a significant effect. Total blood triglycerides, VLDL triglycerides and VLDL cholesterol decreased, and HDL cholesterol increased in the polysulphone high-flux group, while these variables remained unchanged in a group of patients treated with standard dialysers. Objective: Comparisons were made between patients treated with high-flux membrane dialysers and patients treated with low-flux membrane dialysers with regard to quality of life, clinical outcomes and laboratory results. Methods: The study was investigator-driven, cross-sectional and based on the intention-to-treat principle. The study population was composed of patients undergoing dialysis treatment (18 to 70 years of age) in the Studenica regional health centre in Kraljevo. The patients belonged to the low-flux haemodialysis group (n=33) or the high-flux haemodialysis (n=39) group. The patients were interviewed between December 2009 and January 2010. The results of laboratory tests and data on comorbidities were obtained from medical records. Information regarding quality of life and habits were obtained using the Comprehensive Quality of Life Scale - Adult. Results: Serum levels of urea were significantly different between patients who were treated with high-flux membrane dialysers and those who were treated with low-flux membrane dialysers (t=2, 094, p=0.040). No significant differences were found regarding other laboratory parameters, clinical symptoms, comorbidities, habits, or patients' quality of life. Conclusion: Although high-porosity high-flux haemodialysis membranes remove waste solutes more efficiently than low-flux membranes with smaller pores, this fact did not translate into significant differences in patients' quality of life.