The Type A Behavior Pattern (TABP) is associated with elevated heart rate(HR) and blood pressure (BP) responses by women during the structured interview (SI) for TABP. Moderate physical activity (PA) (~60% max METS) reduces resting HR and BP in women with mild hypertension. We hypothesized that habitual PA at ~6 METS would blunt HR and BP response to the SI in Type A women with parental history of hypertension. Fifty-nine normotensive women (21+ 2 y) having one or both parents diagnosed with hypertension were rated as Type A or Type B using the SI. Median splits on PA (kJ·kg-1·wk-1) reported from the 7d recall interview formed high vs low groups on total-PA (1265.4 vs 1039.9) and 6 METS-PA (163.4 vs 19.9), p<0.001. The 6 METS-PA groups were confirmed by V·O2peak(ml·kg-1·min-1) (43.9 vs 38.3), p <0.05: groups did not differ on Quetelet's body mass index. On another day, beat-to-beat HR, systolic (SBP), diastolic (DBP) and mean arterial (MAP) blood pressures were monitored by photoplethysmography (Finapres) during the last 5-min of a 15-min baseline and every 2 min during the SI with subjects seated. Mixed model ANOVA, 2(TABP) × 2(PA) × (time: baseline vs peak), indicated no effects of TABP or total-PA on HR or BP. The high 6 METS-PA group had lower DBP, F(1,55)=7.05, and MAP, F(1,55)=6.10, at rest vs the low 6 METS-PA group, p<0.05. A TABP × 6 METS-PA effect, F(1,55)=7.44, <0.01, indicated that high-active Type A's had an elevated HR response to the SI compared with high-active and low-active Type B's, p<0.05. Trait anxiety (STAI-Y2) and trait anger (STAXI) were unrelated to HR or BP responses. We conclude that physical activity of moderate intensity is inversely associated with resting diastolic and mean arterial blood pressures in young women with parental hypertension, independently of TABP or elevated HR responses to the SI by Type A women who are moderately active.